AZD-7648_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the AZD-7648_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.133321
EFNA5 ephrin-A5 0.131052
RPL37A ribosomal protein L37a 0.10769
CEMIP cell migration inducing protein, hyaluronan binding 0.106869
PDE4D phosphodiesterase 4D, cAMP-specific 0.101746
RPS12 ribosomal protein S12 0.0962292
RPS6 ribosomal protein S6 0.085289
LIMCH1 LIM and calponin homology domains 1 0.0822928
RPL18 ribosomal protein L18 0.0789906
TTC3 tetratricopeptide repeat domain 3 0.0777664
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0769926
LPP LIM domain containing preferred translocation partner in lipoma 0.0741694
RPS3 ribosomal protein S3 0.0738499
PTPRM protein tyrosine phosphatase, receptor type, M 0.0705324
RAD51B RAD51 paralog B 0.0694217
ZSWIM6 zinc finger, SWIM-type containing 6 0.0664989
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0657878
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0651718
SON SON DNA binding protein 0.0645318
KYNU kynureninase 0.0619308
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0604237
NKD1 naked cuticle homolog 1 (Drosophila) 0.0588749
FAM13A family with sequence similarity 13, member A 0.0581385
RPL36 ribosomal protein L36 0.056747
ATXN1 ataxin 1 0.0562568
RPS8 ribosomal protein S8 0.055621
DOCK4 dedicator of cytokinesis 4 0.0549602
FHIT fragile histidine triad 0.0546509
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0542659
CAMKMT calmodulin-lysine N-methyltransferase 0.0536627
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0532783
CCNL1 cyclin L1 0.0529328
PTPRK protein tyrosine phosphatase, receptor type, K 0.0526558
SIK3 SIK family kinase 3 0.0525231
IFI6 interferon, alpha-inducible protein 6 0.0523091
CUX1 cut-like homeobox 1 0.0522776
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0506556
NCEH1 neutral cholesterol ester hydrolase 1 0.0486872
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0485582
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0481838
PARD3 par-3 family cell polarity regulator 0.046776
TBC1D5 TBC1 domain family, member 5 0.0463321
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0461531
CEP350 centrosomal protein 350kDa 0.0460866
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.045951
RPL14 ribosomal protein L14 0.0456423
PCM1 pericentriolar material 1 0.0450164
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0447553
PDLIM5 PDZ and LIM domain 5 0.0444616
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0442249
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0437715
RPS27A ribosomal protein S27a 0.043753
ENO1 enolase 1, (alpha) 0.0432968
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0432469
SEPTIN9 septin 9 0.0431778
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0430688
TJP1 tight junction protein 1 0.0426387
EEF1G eukaryotic translation elongation factor 1 gamma 0.0425531
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0422912
MYOF myoferlin 0.0418364
GPHN gephyrin 0.0417724
RACK1 receptor for activated C kinase 1 0.0414938
FBXL20 F-box and leucine-rich repeat protein 20 0.0412581
C6ORF62 chromosome 6 open reading frame 62 0.0408782
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0408576
SERINC5 serine incorporator 5 0.0405242
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0403081
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0396964
GOLGA4 golgin A4 0.0388515
EGFR epidermal growth factor receptor 0.0388257
RPS20 ribosomal protein S20 0.0387879
PTGES2 prostaglandin E synthase 2 0.038623
FAF1 Fas (TNFRSF6) associated factor 1 0.0384673
ATP11A ATPase, class VI, type 11A 0.0383953
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0382838
ALCAM activated leukocyte cell adhesion molecule 0.0380932
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.037414
RPS19 ribosomal protein S19 0.037146
RPL37 ribosomal protein L37 0.0370713
PALLD palladin, cytoskeletal associated protein 0.037063
TAPBP TAP binding protein (tapasin) 0.0369456
RPL26 ribosomal protein L26 0.0357767
SMYD3 SET and MYND domain containing 3 0.0353572
AK1 adenylate kinase 1 0.0353432
NEBL nebulette 0.0352892
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0351566
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0350564
ZHX2 zinc fingers and homeoboxes 2 0.034988
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0349515
EXOC6B exocyst complex component 6B 0.0347705
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.034397
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0341165
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0334018
ITGA6 integrin, alpha 6 0.0329998
RPL35 ribosomal protein L35 0.0328765
TRIO trio Rho guanine nucleotide exchange factor 0.0327744
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0326027
RPS17 ribosomal protein S17 0.0325816
SENP6 SUMO1/sentrin specific peptidase 6 0.0322296
RSL1D1 ribosomal L1 domain containing 1 0.0319887

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.212111
FN1 fibronectin 1 -0.148678
FTL ferritin, light polypeptide -0.118508
ANXA2 annexin A2 -0.107816
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104243
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0930744
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0894963
GRB10 growth factor receptor-bound protein 10 -0.0812416
TMSB10 thymosin beta 10 -0.0803833
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0756006
HELZ helicase with zinc finger -0.0729126
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0687292
ANXA1 annexin A1 -0.0680907
NAMPT nicotinamide phosphoribosyltransferase -0.0661599
SEC31A SEC31 homolog A (S. cerevisiae) -0.0647744
PRRC2C proline-rich coiled-coil 2C -0.0639203
HMGA1 high mobility group AT-hook 1 -0.063647
GPC6 glypican 6 -0.0627356
S100A9 S100 calcium binding protein A9 -0.0616306
COPA coatomer protein complex, subunit alpha -0.0616226
NDRG1 N-myc downstream regulated 1 -0.0607662
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0604513
ACBD3 acyl-CoA binding domain containing 3 -0.0599997
WAC WW domain containing adaptor with coiled-coil -0.0597002
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0551502
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0547047
VMP1 vacuole membrane protein 1 -0.0546933
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0545569
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0539749
STAU1 staufen double-stranded RNA binding protein 1 -0.0537929
TOP1 topoisomerase (DNA) I -0.0534872
MYO10 myosin X -0.0514948
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0513239
LAMC2 laminin, gamma 2 -0.0509011
NPEPPS aminopeptidase puromycin sensitive -0.0500868
SPAG9 sperm associated antigen 9 -0.0500189
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0498837
SDC4 syndecan 4 -0.0494897
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0490801
YAP1 Yes-associated protein 1 -0.0488325
TRA2A transformer 2 alpha homolog (Drosophila) -0.0484999
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0482207
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0481847
SRP54 signal recognition particle 54kDa -0.0477677
UBE2B ubiquitin-conjugating enzyme E2B -0.0474568
ARF1 ADP-ribosylation factor 1 -0.0472972
CD44 CD44 molecule (Indian blood group) -0.0467203
ARHGAP5 Rho GTPase activating protein 5 -0.0466523
ADAM10 ADAM metallopeptidase domain 10 -0.0464365
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0460215
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0459027
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0456289
CALD1 caldesmon 1 -0.045431
RPS4X ribosomal protein S4, X-linked -0.0449184
PLAUR plasminogen activator, urokinase receptor -0.0449142
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.044831
MSI2 musashi RNA-binding protein 2 -0.0448109
IFRD1 interferon-related developmental regulator 1 -0.0445277
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0444264
SRPK2 SRSF protein kinase 2 -0.0438456
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0437705
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0429949
POTEF POTE ankyrin domain family, member F -0.0426281
SFTPA2 surfactant protein A2 -0.0421888
CYTH1 cytohesin 1 -0.0420579
S100A6 S100 calcium binding protein A6 -0.0417536
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0416391
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0413198
SETD5 SET domain containing 5 -0.0410137
GDF15 growth differentiation factor 15 -0.0408643
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0407779
S100A10 S100 calcium binding protein A10 -0.0407616
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0406359
NCOA3 nuclear receptor coactivator 3 -0.0395149
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0393974
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0393963
TPM4 tropomyosin 4 -0.0392354
PHF21A PHD finger protein 21A -0.039124
RBM39 RNA binding motif protein 39 -0.0389928
FUS FUS RNA binding protein -0.0389056
SPATS2 spermatogenesis associated, serine-rich 2 -0.0388395
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0386428
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0380425
ANKRD12 ankyrin repeat domain 12 -0.0380186
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0378137
KDM4C lysine (K)-specific demethylase 4C -0.0376497
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0376302
INTS6 integrator complex subunit 6 -0.0375877
FTH1 ferritin, heavy polypeptide 1 -0.0375477
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0374436
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0374136
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0373464
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0371607
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.036929
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0369116
MSN moesin -0.0368395
STC1 stanniocalcin 1 -0.0367781
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0363256
HDLBP high density lipoprotein binding protein -0.0361531
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0360676