| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-7648_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| YBX3 | Y box binding protein 3 | 0.177121 |
| RPS3 | ribosomal protein S3 | 0.123172 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.109652 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.106165 |
| TXNRD1 | thioredoxin reductase 1 | 0.102063 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0961168 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0878694 |
| HSPA8 | heat shock 70kDa protein 8 | 0.08483 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0720394 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.069985 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0650328 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0601234 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0554756 |
| RPS8 | ribosomal protein S8 | 0.0551388 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0544166 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0542117 |
| BRD2 | bromodomain containing 2 | 0.0489329 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0460883 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0456593 |
| GOLGB1 | golgin B1 | 0.0424512 |
| MORF4L2 | mortality factor 4 like 2 | 0.0422836 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0421347 |
| RPS12 | ribosomal protein S12 | 0.0397529 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0389589 |
| TPI1 | triosephosphate isomerase 1 | 0.0384134 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0373503 |
| JMJD1C | jumonji domain containing 1C | 0.0372211 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0369925 |
| RBM39 | RNA binding motif protein 39 | 0.0369234 |
| B2M | beta-2-microglobulin | 0.0362062 |
| RPL37A | ribosomal protein L37a | 0.0360339 |
| H1-0 | H1.0 linker histone | 0.0352615 |
| TAPBP | TAP binding protein (tapasin) | 0.034952 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0348321 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0346604 |
| HOMER1 | homer scaffolding protein 1 | 0.0343769 |
| CALD1 | caldesmon 1 | 0.0343337 |
| RPS4X | ribosomal protein S4, X-linked | 0.0340664 |
| GRAMD1B | GRAM domain containing 1B | 0.0338629 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0334205 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0327329 |
| TPM3 | tropomyosin 3 | 0.0321194 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0319021 |
| FUS | FUS RNA binding protein | 0.0317463 |
| RPS6 | ribosomal protein S6 | 0.031546 |
| RPL37 | ribosomal protein L37 | 0.0314663 |
| CAVIN1 | caveolae associated protein 1 | 0.0313054 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0311664 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0311664 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0311489 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0307978 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0307967 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0306956 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0304982 |
| RACK1 | receptor for activated C kinase 1 | 0.0303916 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.029797 |
| FTL | ferritin, light polypeptide | 0.0297226 |
| VMP1 | vacuole membrane protein 1 | 0.0296429 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0294641 |
| RPL26 | ribosomal protein L26 | 0.0294633 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0292751 |
| SIK3 | SIK family kinase 3 | 0.0292207 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.028999 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.028925 |
| TLN1 | talin 1 | 0.0287815 |
| RPL14 | ribosomal protein L14 | 0.0287241 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0287113 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0283991 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0283684 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0281424 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0279495 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0275744 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.027441 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0273945 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0272503 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0272211 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0266004 |
| RPS27A | ribosomal protein S27a | 0.0262047 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0261519 |
| WBP11 | WW domain binding protein 11 | 0.0256872 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0254942 |
| TOP1 | topoisomerase (DNA) I | 0.0254898 |
| MYPN | myopalladin | 0.0249902 |
| DST | dystonin | 0.024858 |
| ASPH | aspartate beta-hydroxylase | 0.0247266 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0247262 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0244871 |
| ATP11A | ATPase, class VI, type 11A | 0.0243839 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0243031 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0242281 |
| CLTC | clathrin, heavy chain (Hc) | 0.0241767 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0241389 |
| VCP | valosin containing protein | 0.0240199 |
| GOLGA4 | golgin A4 | 0.0238671 |
| NCKAP1 | NCK-associated protein 1 | 0.0237868 |
| TPR | translocated promoter region, nuclear basket protein | 0.0237825 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0235725 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0235668 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0234287 |
| CAPRIN2 | caprin family member 2 | 0.0233421 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.248117 |
| RAD51B | RAD51 paralog B | -0.126633 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0888105 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0879121 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0776118 |
| VIM | vimentin | -0.075126 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0726188 |
| HMGA2 | high mobility group AT-hook 2 | -0.0721406 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0715692 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0670385 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0625644 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0589506 |
| RYR3 | ryanodine receptor 3 | -0.0571428 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0547074 |
| EGFR | epidermal growth factor receptor | -0.0529972 |
| EXOC4 | exocyst complex component 4 | -0.0508795 |
| EGR1 | early growth response 1 | -0.0468287 |
| USP34 | ubiquitin specific peptidase 34 | -0.0430925 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0415116 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0408639 |
| DENND5B | DENN/MADD domain containing 5B | -0.0405117 |
| MCL1 | myeloid cell leukemia 1 | -0.0392998 |
| PFN1 | profilin 1 | -0.0387513 |
| PKM | pyruvate kinase, muscle | -0.03818 |
| SBF2 | SET binding factor 2 | -0.0375586 |
| ATXN1 | ataxin 1 | -0.0373589 |
| POTEF | POTE ankyrin domain family, member F | -0.037056 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0368456 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0366003 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.035624 |
| PYGL | phosphorylase, glycogen, liver | -0.0344281 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0335203 |
| TPM4 | tropomyosin 4 | -0.0329561 |
| NLGN1 | neuroligin 1 | -0.0329209 |
| FBXO11 | F-box protein 11 | -0.0328961 |
| TUBA1B | tubulin, alpha 1b | -0.0327335 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0321073 |
| CUX1 | cut-like homeobox 1 | -0.0316804 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0312397 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0311077 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0305396 |
| FMN1 | formin 1 | -0.0304492 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0303429 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0302912 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0299258 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0298799 |
| HMGA1 | high mobility group AT-hook 1 | -0.0297016 |
| TMEM165 | transmembrane protein 165 | -0.0291484 |
| CDCP1 | CUB domain containing protein 1 | -0.0290391 |
| SMAD3 | SMAD family member 3 | -0.0290111 |
| NCOA7 | nuclear receptor coactivator 7 | -0.028846 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0283359 |
| GNAS | GNAS complex locus | -0.0282845 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0282812 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0277206 |
| BBX | bobby sox homolog (Drosophila) | -0.0274849 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0273039 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0270276 |
| BSG | basigin (Ok blood group) | -0.0268359 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0268226 |
| ATG7 | autophagy related 7 | -0.0268054 |
| TMSB10 | thymosin beta 10 | -0.0267034 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0265667 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0263641 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0258619 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0257233 |
| ZNF292 | zinc finger protein 292 | -0.0254508 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0253813 |
| TWF1 | twinfilin actin binding protein 1 | -0.0253432 |
| SRPK1 | SRSF protein kinase 1 | -0.0253102 |
| TAOK1 | TAO kinase 1 | -0.0250607 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0250493 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0246054 |
| RSF1 | remodeling and spacing factor 1 | -0.0245605 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0245439 |
| EHBP1 | EH domain binding protein 1 | -0.0242813 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0241735 |
| RPS24 | ribosomal protein S24 | -0.0241328 |
| ZNF609 | zinc finger protein 609 | -0.0240862 |
| TLK1 | tousled-like kinase 1 | -0.0238516 |
| PCNX1 | pecanex 1 | -0.023785 |
| ATG10 | autophagy related 10 | -0.0235962 |
| ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | -0.0235196 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0234823 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0234108 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0232089 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0231842 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0231199 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0229055 |
| LATS1 | large tumor suppressor kinase 1 | -0.0227777 |
| KLHL5 | kelch-like family member 5 | -0.0227016 |
| CCDC91 | coiled-coil domain containing 91 | -0.0226277 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0225134 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0223103 |
| DENND1A | DENN/MADD domain containing 1A | -0.022045 |
| PTK2 | protein tyrosine kinase 2 | -0.0216146 |
| RFX7 | regulatory factor X, 7 | -0.0215573 |
| WASF2 | WAS protein family, member 2 | -0.0215042 |
| TNRC6B | trinucleotide repeat containing 6B | -0.021058 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0210348 |
