| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-7648_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.164782 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.141816 |
| RPS3 | ribosomal protein S3 | 0.0972602 |
| FTL | ferritin, light polypeptide | 0.0933376 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0867465 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0856368 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0817603 |
| GOLGB1 | golgin B1 | 0.0771657 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0740051 |
| POTEF | POTE ankyrin domain family, member F | 0.0687633 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0687285 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0662445 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0598688 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0594293 |
| TAPBP | TAP binding protein (tapasin) | 0.0589107 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0581358 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.051362 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0511337 |
| BRD2 | bromodomain containing 2 | 0.0498536 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0491139 |
| TMF1 | TATA element modulatory factor 1 | 0.0486326 |
| MSN | moesin | 0.0472998 |
| DSPP | dentin sialophosphoprotein | 0.0469902 |
| MT2A | metallothionein 2A | 0.0454708 |
| RPS12 | ribosomal protein S12 | 0.0452065 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0433829 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.043113 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0403025 |
| EFNA5 | ephrin-A5 | 0.0393894 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.03934 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0390826 |
| CTSB | cathepsin B | 0.038023 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0374751 |
| FHIT | fragile histidine triad | 0.0372511 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0364513 |
| TPM3 | tropomyosin 3 | 0.0356301 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0345186 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0343508 |
| RPL37A | ribosomal protein L37a | 0.0339418 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0330367 |
| RUNX1 | runt-related transcription factor 1 | 0.0325952 |
| LDHA | lactate dehydrogenase A | 0.0325304 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0322549 |
| RPS6 | ribosomal protein S6 | 0.0321759 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0321215 |
| MYOF | myoferlin | 0.0320809 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0313893 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0311341 |
| RPL14 | ribosomal protein L14 | 0.0309831 |
| ARRDC3 | arrestin domain containing 3 | 0.0308256 |
| INTS6 | integrator complex subunit 6 | 0.0306589 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0305608 |
| SON | SON DNA binding protein | 0.0304851 |
| ANKRD12 | ankyrin repeat domain 12 | 0.030003 |
| ATXN1 | ataxin 1 | 0.0298478 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0297932 |
| NDRG1 | N-myc downstream regulated 1 | 0.0297207 |
| TJP1 | tight junction protein 1 | 0.0293791 |
| VEGFA | vascular endothelial growth factor A | 0.0293157 |
| SEPTIN9 | septin 9 | 0.0287628 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0285347 |
| RACK1 | receptor for activated C kinase 1 | 0.0273357 |
| VGLL3 | vestigial-like family member 3 | 0.0271808 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0271037 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0270833 |
| RNF213 | ring finger protein 213 | 0.0268231 |
| FNIP1 | folliculin interacting protein 1 | 0.0267893 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0267723 |
| FBXO32 | F-box protein 32 | 0.0267572 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0264139 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0263547 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0263306 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.02619 |
| SCFD1 | sec1 family domain containing 1 | 0.025795 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0256759 |
| MKI67 | marker of proliferation Ki-67 | 0.025573 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0255451 |
| HDAC9 | histone deacetylase 9 | 0.0255238 |
| RAD51B | RAD51 paralog B | 0.0254517 |
| NAV2 | neuron navigator 2 | 0.025228 |
| RPS17 | ribosomal protein S17 | 0.0252012 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0251232 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0250937 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0250239 |
| VMP1 | vacuole membrane protein 1 | 0.0247844 |
| NTN4 | netrin 4 | 0.0245966 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0244141 |
| GOLGA4 | golgin A4 | 0.0243956 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0241793 |
| RPL36 | ribosomal protein L36 | 0.0241076 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0238891 |
| ANO6 | anoctamin 6 | 0.0238629 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0237654 |
| RPS2 | ribosomal protein S2 | 0.0235508 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0232355 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0231385 |
| TXNIP | thioredoxin interacting protein | 0.023039 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0229666 |
| MAP1B | microtubule-associated protein 1B | 0.0228737 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0227018 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.26625 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.183347 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.135079 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.084239 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0823922 |
| S100A6 | S100 calcium binding protein A6 | -0.0748622 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0671135 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0625036 |
| HMGA1 | high mobility group AT-hook 1 | -0.06178 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0616331 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0594185 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0571182 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0554971 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.053404 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0529586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.052314 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.051137 |
| TMEM123 | transmembrane protein 123 | -0.05096 |
| TFG | TRK-fused gene | -0.0497572 |
| RPS24 | ribosomal protein S24 | -0.0481709 |
| ASPH | aspartate beta-hydroxylase | -0.0449325 |
| RPLP1 | ribosomal protein, large, P1 | -0.0443882 |
| USP3 | ubiquitin specific peptidase 3 | -0.041346 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0413279 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0410653 |
| ARF1 | ADP-ribosylation factor 1 | -0.0404744 |
| GNAS | GNAS complex locus | -0.0392095 |
| TMSB10 | thymosin beta 10 | -0.0391255 |
| CD2AP | CD2-associated protein | -0.0391176 |
| CCND1 | cyclin D1 | -0.0389116 |
| S100A10 | S100 calcium binding protein A10 | -0.038049 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0379322 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0376131 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0375383 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0368704 |
| ACTG1 | actin gamma 1 | -0.0364081 |
| PGK1 | phosphoglycerate kinase 1 | -0.0356904 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0351769 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0343161 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0341317 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0339 |
| RLF | rearranged L-myc fusion | -0.033886 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0337308 |
| ANXA2 | annexin A2 | -0.0329182 |
| TPM4 | tropomyosin 4 | -0.0321051 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0314547 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0314415 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0309814 |
| CDK17 | cyclin-dependent kinase 17 | -0.0308707 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0306324 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0305341 |
| ZNF207 | zinc finger protein 207 | -0.0301105 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0298727 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0297271 |
| TKT | transketolase | -0.029672 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0296665 |
| ZNF292 | zinc finger protein 292 | -0.0292428 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0292332 |
| CDC73 | cell division cycle 73 | -0.0291348 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0287956 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.028785 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0287752 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0281688 |
| TOP1 | topoisomerase (DNA) I | -0.0281478 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0281022 |
| PLAU | plasminogen activator, urokinase | -0.0280084 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.027556 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0273271 |
| CTSD | cathepsin D | -0.0270727 |
| RHEB | Ras homolog enriched in brain | -0.0269665 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0266724 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0266396 |
| KRT18 | keratin 18, type I | -0.0265101 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0263948 |
| SLMAP | sarcolemma associated protein | -0.0262708 |
| SPAG9 | sperm associated antigen 9 | -0.0260176 |
| FNDC3B | fibronectin type III domain containing 3B | -0.025952 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0256186 |
| RNF145 | ring finger protein 145 | -0.0252069 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0249749 |
| FAM162A | family with sequence similarity 162, member A | -0.0249748 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0249036 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0248671 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0246838 |
| RPLP0 | ribosomal protein, large, P0 | -0.0246601 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0245982 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0242313 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0240321 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0239427 |
| QKI | QKI, KH domain containing, RNA binding | -0.0238965 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.0237427 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0236373 |
| MATR3 | matrin 3 | -0.0235037 |
| MORF4L1 | mortality factor 4 like 1 | -0.0228761 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0227623 |
| FAM3C | family with sequence similarity 3, member C | -0.0225369 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0223708 |
| CANX | calnexin | -0.0219826 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0216264 |
| ATP13A3 | ATPase type 13A3 | -0.021573 |
