AZD-7648_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.153452
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.106001
VIM vimentin 0.096491
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0917032
RGS2 regulator of G-protein signaling 2 0.0908308
RPS3 ribosomal protein S3 0.0895556
TMSB10 thymosin beta 10 0.0820656
RPS12 ribosomal protein S12 0.0803295
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0772913
DST dystonin 0.0772702
MT2A metallothionein 2A 0.0770369
RPS8 ribosomal protein S8 0.0728899
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0702634
PTMA prothymosin, alpha 0.068901
SH3KBP1 SH3-domain kinase binding protein 1 0.0673442
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0667529
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0650727
RPL26 ribosomal protein L26 0.0636956
RACK1 receptor for activated C kinase 1 0.0622521
PRRC2C proline-rich coiled-coil 2C 0.0620979
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0610284
NAP1L1 nucleosome assembly protein 1-like 1 0.0606475
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0590772
RPS19 ribosomal protein S19 0.0586055
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.057098
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0560703
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0556315
CXCL8 chemokine (C-X-C motif) ligand 8 0.0556295
RPL37A ribosomal protein L37a 0.0549467
RPL12 ribosomal protein L12 0.0548849
RPL19 ribosomal protein L19 0.0536798
PSD3 pleckstrin and Sec7 domain containing 3 0.0531101
RPS4X ribosomal protein S4, X-linked 0.0521546
GRAMD1B GRAM domain containing 1B 0.0517074
RPL36 ribosomal protein L36 0.0508203
SMOC1 SPARC related modular calcium binding 1 0.0497607
PM20D1 peptidase M20 domain containing 1 0.0484528
LOC102724023 ES1 protein homolog, mitochondrial 0.0474134
EIF1 eukaryotic translation initiation factor 1 0.0472963
RPS23 ribosomal protein S23 0.047295
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0469646
RPS17 ribosomal protein S17 0.0460271
IGFBP3 insulin-like growth factor binding protein 3 0.0448381
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0448229
RPL32 ribosomal protein L32 0.0447567
LDHA lactate dehydrogenase A 0.0445089
RPL23 ribosomal protein L23 0.0439062
YBX3 Y box binding protein 3 0.0433823
HSPA8 heat shock 70kDa protein 8 0.0433725
PCBP2 poly(rC) binding protein 2 0.0433601
ESYT2 extended synaptotagmin-like protein 2 0.0424561
RAB3B RAB3B, member RAS oncogene family 0.0417259
RPL18 ribosomal protein L18 0.0408014
APLP2 amyloid beta (A4) precursor-like protein 2 0.0404921
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0404183
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0397147
GOLGA4 golgin A4 0.0394535
KYNU kynureninase 0.0391688
ZSWIM6 zinc finger, SWIM-type containing 6 0.0387115
PDE10A phosphodiesterase 10A 0.0381953
EFNA5 ephrin-A5 0.0381633
SLC38A2 solute carrier family 38, member 2 0.0372987
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0371166
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0368944
RPS2 ribosomal protein S2 0.0367888
RPS27 ribosomal protein S27 0.036014
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0355474
EEF1G eukaryotic translation elongation factor 1 gamma 0.0352807
TPM3 tropomyosin 3 0.0352091
SET SET nuclear proto-oncogene 0.0351763
SRGN serglycin 0.0349783
ASTN2 astrotactin 2 0.0348647
NFE2L2 nuclear factor, erythroid 2-like 2 0.0347638
DUSP4 dual specificity phosphatase 4 0.0346485
KTN1 kinectin 1 (kinesin receptor) 0.034488
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0343085
EZR ezrin 0.0341941
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0341104
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0327926
CTIF CBP80/20-dependent translation initiation factor 0.0315141
RPS14 ribosomal protein S14 0.0314996
EIF3A eukaryotic translation initiation factor 3, subunit A 0.031133
TBXT T-box transcription factor T 0.0311188
CENPF centromere protein F, 350/400kDa 0.0309628
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0305971
RPL31 ribosomal protein L31 0.0305665
RPL5 ribosomal protein L5 0.0303144
SRRM2 serine/arginine repetitive matrix 2 0.0301227
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.030027
RPL9 ribosomal protein L9 0.0299282
GOLGB1 golgin B1 0.0298594
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0292465
FLNB filamin B, beta 0.0291176
RPL11 ribosomal protein L11 0.0288498
PDIA6 protein disulfide isomerase family A, member 6 0.0288377
RPL37 ribosomal protein L37 0.0285625
RPS29 ribosomal protein S29 0.028274
TGFBR1 transforming growth factor, beta receptor 1 0.028208
B2M beta-2-microglobulin 0.0278895
RPL7 ribosomal protein L7 0.0278489

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.264705
PDE4D phosphodiesterase 4D, cAMP-specific -0.121903
SMYD3 SET and MYND domain containing 3 -0.107548
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0997181
COL5A2 collagen, type V, alpha 2 -0.0994391
NALF1 NALCN channel auxiliary factor 1 -0.0972042
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0940921
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.079961
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0654024
NAMPT nicotinamide phosphoribosyltransferase -0.0493273
TXNRD1 thioredoxin reductase 1 -0.0490088
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0475882
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0445981
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0439456
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0429018
NCKAP5 NCK-associated protein 5 -0.0387948
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0369575
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0362837
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0347753
PALLD palladin, cytoskeletal associated protein -0.0321596
TRIO trio Rho guanine nucleotide exchange factor -0.0309747
PTGR1 prostaglandin reductase 1 -0.0301807
FNDC3B fibronectin type III domain containing 3B -0.0300795
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0299521
WARS1 tryptophanyl-tRNA synthetase 1 -0.0296577
ADGRB3 adhesion G protein-coupled receptor B3 -0.0286366
TENM3 teneurin transmembrane protein 3 -0.0281768
WSB1 WD repeat and SOCS box containing 1 -0.0280677
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0280078
IGF1R insulin-like growth factor 1 receptor -0.027528
AUTS2 autism susceptibility candidate 2 -0.0273289
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0263336
PCBP3 poly(rC) binding protein 3 -0.0259602
AKR1C1 aldo-keto reductase family 1, member C1 -0.0251216
OSMR oncostatin M receptor -0.0241603
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0238883
NCOA7 nuclear receptor coactivator 7 -0.0238348
NTN4 netrin 4 -0.0223814
SPAG9 sperm associated antigen 9 -0.022149
PDE1A phosphodiesterase 1A, calmodulin-dependent -0.021968
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0219386
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0213037
TPM4 tropomyosin 4 -0.0209952
ZFHX3 zinc finger homeobox 3 -0.0207981
TGFBI transforming growth factor, beta-induced, 68kDa -0.0207055
BCAS3 breast carcinoma amplified sequence 3 -0.0204726
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0202853
AOPEP aminopeptidase O (putative) -0.0200297
EXT1 exostosin glycosyltransferase 1 -0.0194989
ADGRD1 adhesion G protein-coupled receptor D1 -0.0194779
AKR1C2 aldo-keto reductase family 1, member C2 -0.0193475
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0192608
MFSD12 major facilitator superfamily domain containing 12 -0.0192459
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0189839
SOX6 SRY (sex determining region Y)-box 6 -0.018878
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.018757
DCLK2 doublecortin-like kinase 2 -0.0186184
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0185736
THSD4 thrombospondin, type I, domain containing 4 -0.0182812
NRCAM neuronal cell adhesion molecule -0.0182538
RPH3AL rabphilin 3A-like (without C2 domains) -0.0181809
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0181045
CLIP1 CAP-GLY domain containing linker protein 1 -0.0174867
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0173893
STEAP1B STEAP family member 1B -0.0170311
SCN3A sodium channel, voltage gated, type III alpha subunit -0.017028
ABLIM1 actin binding LIM protein 1 -0.0166215
LSAMP limbic system-associated membrane protein -0.0164091
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0163255
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0163119
TTC28 tetratricopeptide repeat domain 28 -0.0162718
ZMYND8 zinc finger, MYND-type containing 8 -0.0161782
CDH13 cadherin 13 -0.0161645
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0160636
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0159098
KDM3A lysine (K)-specific demethylase 3A -0.0157964
TENM2 teneurin transmembrane protein 2 -0.0157379
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0156373
RIGI RNA sensor RIG-I -0.0156329
OLFML2A olfactomedin-like 2A -0.0154298
GRB10 growth factor receptor-bound protein 10 -0.0154213
DISP1 dispatched homolog 1 (Drosophila) -0.0152537
SOD2 superoxide dismutase 2, mitochondrial -0.0152098
MEGF6 multiple EGF-like-domains 6 -0.0151758
AFG2A AFG2 AAA ATPase homolog A -0.0150839
NPEPPS aminopeptidase puromycin sensitive -0.0149111
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0148208
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0147401
TMX4 thioredoxin-related transmembrane protein 4 -0.0146374
UBE2H ubiquitin-conjugating enzyme E2H -0.0145914
MAML2 mastermind-like 2 (Drosophila) -0.0144169
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0142914
FRY furry homolog (Drosophila) -0.0142479
PBX1 pre-B-cell leukemia homeobox 1 -0.0140514
CUX1 cut-like homeobox 1 -0.0140218
UGDH UDP-glucose 6-dehydrogenase -0.0139007
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.013658
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0136244
AHR aryl hydrocarbon receptor -0.013508
QPCT glutaminyl-peptide cyclotransferase -0.0135026