AZD-7648_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

99 genes differentially expressed following the AZD-7648_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.246592
FAT1 FAT atypical cadherin 1 0.228443
LAMB3 laminin, beta 3 0.157605
MYO1E myosin IE 0.132257
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.128434
IGFBP3 insulin-like growth factor binding protein 3 0.111491
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0950419
LMO7 LIM domain 7 0.0930264
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0927961
LPP LIM domain containing preferred translocation partner in lipoma 0.0924637
NDRG1 N-myc downstream regulated 1 0.0874652
TMSB10 thymosin beta 10 0.0866062
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0815195
ANXA2 annexin A2 0.0806222
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0779493
ZFAND3 zinc finger, AN1-type domain 3 0.0757264
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0737944
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.073775
FNDC3B fibronectin type III domain containing 3B 0.0735499
S100A10 S100 calcium binding protein A10 0.0731973
RPS8 ribosomal protein S8 0.0680346
RPS6 ribosomal protein S6 0.0638628
PDE4D phosphodiesterase 4D, cAMP-specific 0.0623987
RPL31 ribosomal protein L31 0.0582288
AKAP12 A kinase (PRKA) anchor protein 12 0.0570468
RPS27A ribosomal protein S27a 0.0489198
PARD3 par-3 family cell polarity regulator 0.0478448
RPS23 ribosomal protein S23 0.0475814
RPS19 ribosomal protein S19 0.0471411
RPS3 ribosomal protein S3 0.0437085
LDHA lactate dehydrogenase A 0.0399507
ACTG1 actin gamma 1 0.0389357
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0375399
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0342806
ZSWIM6 zinc finger, SWIM-type containing 6 0.0325502
PRELID2 PRELI domain containing 2 0.0311913
ASPH aspartate beta-hydroxylase 0.0300542
PKM pyruvate kinase, muscle 0.0295996
RAB7A RAB7A, member RAS oncogene family 0.0279074
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0263996
TXNRD1 thioredoxin reductase 1 0.0251112
RPL37 ribosomal protein L37 0.0250038
EZR ezrin 0.0245809
SLC38A1 solute carrier family 38, member 1 0.0235766
KTN1 kinectin 1 (kinesin receptor) 0.0215735
RPS13 ribosomal protein S13 0.021077
RPL37A ribosomal protein L37a 0.0205875
MCL1 myeloid cell leukemia 1 0.0192982
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0174351
TPM4 tropomyosin 4 0.0151663
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00722084
ENO1 enolase 1, (alpha) 0.00463703
DSCAM Down syndrome cell adhesion molecule 0.00344746
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.00298681
EIF1 eukaryotic translation initiation factor 1 0.00212016
SPAG9 sperm associated antigen 9 0.0016181
SLTM SAFB-like, transcription modulator 0.00126524

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.221737
VIM vimentin -0.185944
EGFR epidermal growth factor receptor -0.136247
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.13113
CD44 CD44 molecule (Indian blood group) -0.102298
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0996897
MT2A metallothionein 2A -0.0958273
ZNF292 zinc finger protein 292 -0.094111
B2M beta-2-microglobulin -0.0940789
TRIO trio Rho guanine nucleotide exchange factor -0.0803235
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0776268
MYO6 myosin VI -0.0752063
MAML3 mastermind-like 3 (Drosophila) -0.0709954
INHBA inhibin, beta A -0.0709238
RTN4 reticulon 4 -0.0682039
ELL2 elongation factor, RNA polymerase II, 2 -0.0664436
PRRC2C proline-rich coiled-coil 2C -0.0621938
USP34 ubiquitin specific peptidase 34 -0.0611203
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0607645
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0589887
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0578209
PTK2 protein tyrosine kinase 2 -0.0557287
TPT1 tumor protein, translationally-controlled 1 -0.0549536
RPL12 ribosomal protein L12 -0.0528495
HDLBP high density lipoprotein binding protein -0.0513222
RPLP1 ribosomal protein, large, P1 -0.0489837
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0481514
RPL26 ribosomal protein L26 -0.0477667
LRP1B low density lipoprotein receptor-related protein 1B -0.0470814
SBF2 SET binding factor 2 -0.0411277
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0399888
RPS12 ribosomal protein S12 -0.0380754
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.034809
EXT1 exostosin glycosyltransferase 1 -0.0326352
FTL ferritin, light polypeptide -0.0315016
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0280063
GOLGA4 golgin A4 -0.027346
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0256471
PTMA prothymosin, alpha -0.0240376
RPL35A ribosomal protein L35a -0.0133007
POTEF POTE ankyrin domain family, member F -0.00804613
RPL23 ribosomal protein L23 -0.00143967