AZD-7648_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.119968
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0907737
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0750768
PCDH7 protocadherin 7 0.0735362
RPS6 ribosomal protein S6 0.0637941
LDHA lactate dehydrogenase A 0.0585596
AKAP12 A kinase (PRKA) anchor protein 12 0.0580664
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0577795
PTMA prothymosin, alpha 0.0507294
B2M beta-2-microglobulin 0.0501669
CADM2 cell adhesion molecule 2 0.0484389
HMGA2 high mobility group AT-hook 2 0.0459562
RPS3 ribosomal protein S3 0.0454518
MYH9 myosin, heavy chain 9, non-muscle 0.041777
RPS12 ribosomal protein S12 0.0414734
APLP2 amyloid beta (A4) precursor-like protein 2 0.0406604
GREB1L growth regulation by estrogen in breast cancer-like 0.0401447
CD44 CD44 molecule (Indian blood group) 0.0399739
ADGRV1 adhesion G protein-coupled receptor V1 0.0393303
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0376052
PCLO piccolo presynaptic cytomatrix protein 0.037551
RPL31 ribosomal protein L31 0.0361864
RPL37A ribosomal protein L37a 0.035761
FN1 fibronectin 1 0.0327462
SAMD4A sterile alpha motif domain containing 4A 0.032586
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0323985
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0321512
DOCK5 dedicator of cytokinesis 5 0.0312177
DOP1B DOP1 leucine zipper like protein B 0.0310369
STC1 stanniocalcin 1 0.0305136
TAPBP TAP binding protein (tapasin) 0.0302866
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0302533
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0296001
KTN1 kinectin 1 (kinesin receptor) 0.029431
COL6A3 collagen, type VI, alpha 3 0.0285021
OSBPL10 oxysterol binding protein-like 10 0.0278928
ASPH aspartate beta-hydroxylase 0.027856
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0277533
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0275751
NAV2 neuron navigator 2 0.0272705
MBD5 methyl-CpG binding domain protein 5 0.0267164
H1-0 H1.0 linker histone 0.026653
IGFBP3 insulin-like growth factor binding protein 3 0.0263206
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0258658
SKIL SKI-like proto-oncogene 0.0258624
RPL36 ribosomal protein L36 0.0257667
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0257363
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0255293
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0253532
MSN moesin 0.0252102
FTL ferritin, light polypeptide 0.02483
CNRIP1 cannabinoid receptor interacting protein 1 0.0247609
GOLGB1 golgin B1 0.0246061
MT2A metallothionein 2A 0.0238515
CNTN6 contactin 6 0.0237932
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0232681
RPS17 ribosomal protein S17 0.0229178
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0228291
GPC4 glypican 4 0.0226696
HMCN1 hemicentin 1 0.0224064
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0223029
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0222771
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.022262
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0221841
RPS19 ribosomal protein S19 0.0221631
NALF1 NALCN channel auxiliary factor 1 0.0220734
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0218742
UNC5C unc-5 homolog C (C. elegans) 0.0215575
ZNF146 zinc finger protein 146 0.0213024
LMO7 LIM domain 7 0.0212276
CDH8 cadherin 8, type 2 0.0211151
ISG15 ISG15 ubiquitin-like modifier 0.0211068
NDRG1 N-myc downstream regulated 1 0.0210127
LPP LIM domain containing preferred translocation partner in lipoma 0.0209822
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0209196
ENO1 enolase 1, (alpha) 0.0209159
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0208446
SFTPA2 surfactant protein A2 0.0206973
PLCB4 phospholipase C, beta 4 0.0206565
RACK1 receptor for activated C kinase 1 0.0205931
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.020527
EEF1G eukaryotic translation elongation factor 1 gamma 0.0203022
MAML2 mastermind-like 2 (Drosophila) 0.0202697
NRDC nardilysin convertase 0.0201264
BRD2 bromodomain containing 2 0.0200515
PCDH9 protocadherin 9 0.0198543
RO60 Ro60, Y RNA binding protein 0.0197819
EHBP1 EH domain binding protein 1 0.0197483
NRXN1 neurexin 1 0.0197447
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0195635
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0194492
SMC1A structural maintenance of chromosomes 1A 0.0192576
CLIC4 chloride intracellular channel 4 0.0189521
ALCAM activated leukocyte cell adhesion molecule 0.018929
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0186768
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 0.0186537
RPS2 ribosomal protein S2 0.0185959
FST follistatin 0.0185863
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.018584
HSPA8 heat shock 70kDa protein 8 0.0185419

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148606
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.12575
ZNF292 zinc finger protein 292 -0.117753
TSC22D2 TSC22 domain family, member 2 -0.113141
PEG10 paternally expressed 10 -0.10796
ZFAND3 zinc finger, AN1-type domain 3 -0.0987854
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0966535
PGAP1 post-GPI attachment to proteins 1 -0.0936971
THBS1 thrombospondin 1 -0.0889368
HDAC9 histone deacetylase 9 -0.0872553
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0725387
STRN3 striatin, calmodulin binding protein 3 -0.0721774
SRP54 signal recognition particle 54kDa -0.0706923
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0686081
ZEB2 zinc finger E-box binding homeobox 2 -0.0673074
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0672646
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0662907
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0640789
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0632031
PLPP1 phospholipid phosphatase 1 -0.0619748
FAM171B family with sequence similarity 171, member B -0.0574817
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0553381
FNDC3B fibronectin type III domain containing 3B -0.0544244
KDM3A lysine (K)-specific demethylase 3A -0.0542924
GNAS GNAS complex locus -0.0531134
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0531081
ANKRD33B ankyrin repeat domain 33B -0.0516208
RLF rearranged L-myc fusion -0.0501387
MRPS30 mitochondrial ribosomal protein S30 -0.0485933
RAD21 RAD21 homolog (S. pombe) -0.0482379
MARCHF6 membrane associated ring-CH-type finger 6 -0.0481149
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0462072
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0461214
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0458251
KMT2C lysine (K)-specific methyltransferase 2C -0.0451862
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0448936
RPS16 ribosomal protein S16 -0.0446454
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0445562
SRPK2 SRSF protein kinase 2 -0.0440022
PHIP pleckstrin homology domain interacting protein -0.0437011
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0435741
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0432956
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0428358
FBXO11 F-box protein 11 -0.0419885
RBM39 RNA binding motif protein 39 -0.0419191
RHEB Ras homolog enriched in brain -0.0417613
ADGRL2 adhesion G protein-coupled receptor L2 -0.0416941
CDC73 cell division cycle 73 -0.0412405
RBM20 RNA binding motif protein 20 -0.0411908
JMJD1C jumonji domain containing 1C -0.0405824
PUM1 pumilio RNA-binding family member 1 -0.0404929
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0401258
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0394163
MTF2 metal response element binding transcription factor 2 -0.0393907
CXADR coxsackie virus and adenovirus receptor -0.0393316
USP25 ubiquitin specific peptidase 25 -0.0392012
ADAM9 ADAM metallopeptidase domain 9 -0.0391537
UPP1 uridine phosphorylase 1 -0.0389941
TMSB4X thymosin beta 4, X-linked -0.0382887
RYBP RING1 and YY1 binding protein -0.037657
ACTN4 actinin, alpha 4 -0.0369099
NRG1 neuregulin 1 -0.0366308
CAMTA1 calmodulin binding transcription activator 1 -0.0365697
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0361381
IGF1R insulin-like growth factor 1 receptor -0.0357067
PDGFC platelet derived growth factor C -0.0356176
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0350233
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0348928
SETD5 SET domain containing 5 -0.0347078
PNISR PNN-interacting serine/arginine-rich protein -0.0345032
STAG2 stromal antigen 2 -0.0344596
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0342463
TTC28 tetratricopeptide repeat domain 28 -0.0340701
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0339751
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0339103
TRA2A transformer 2 alpha homolog (Drosophila) -0.0331608
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0327506
TPR translocated promoter region, nuclear basket protein -0.0326595
MAP4 microtubule-associated protein 4 -0.0326491
ELF2 E74-like factor 2 (ets domain transcription factor) -0.032501
ZNF385D zinc finger protein 385D -0.0323396
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0322853
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0320111
NOP58 NOP58 ribonucleoprotein -0.0319009
HMGB1 high mobility group box 1 -0.0318282
EMP1 epithelial membrane protein 1 -0.0317697
USP3 ubiquitin specific peptidase 3 -0.0317556
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0317274
ZFR zinc finger RNA binding protein -0.0316836
ZNF217 zinc finger protein 217 -0.0313476
EVI5 ecotropic viral integration site 5 -0.0312964
PUM2 pumilio RNA-binding family member 2 -0.030982
ARL13B ADP-ribosylation factor-like 13B -0.0308822
VGLL3 vestigial-like family member 3 -0.0306345
NIPBL Nipped-B homolog (Drosophila) -0.0303845
KMT2E lysine (K)-specific methyltransferase 2E -0.030346
TUT4 terminal uridylyl transferase 4 -0.0303109
ASXL1 additional sex combs like transcriptional regulator 1 -0.0302546
DMD dystrophin -0.0302527
PTK2 protein tyrosine kinase 2 -0.0298909