| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.52728 |
| RPS3 | ribosomal protein S3 | 0.147716 |
| MT2A | metallothionein 2A | 0.143742 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.120317 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.115309 |
| VCL | vinculin | 0.112037 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0979687 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0974548 |
| VIM | vimentin | 0.0881629 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0814868 |
| CENPF | centromere protein F, 350/400kDa | 0.0799998 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0765733 |
| PTMA | prothymosin, alpha | 0.0720662 |
| DST | dystonin | 0.0709675 |
| RPS12 | ribosomal protein S12 | 0.0709595 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0701164 |
| TMSB10 | thymosin beta 10 | 0.0686234 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0683876 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0662783 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0643797 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0588277 |
| RPS8 | ribosomal protein S8 | 0.0576799 |
| YBX1 | Y box binding protein 1 | 0.0562797 |
| MKI67 | marker of proliferation Ki-67 | 0.0546695 |
| ZFP36 | ZFP36 ring finger protein | 0.0525764 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0523118 |
| RPL35A | ribosomal protein L35a | 0.0509283 |
| RPL37A | ribosomal protein L37a | 0.04909 |
| RACK1 | receptor for activated C kinase 1 | 0.0487215 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0483434 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0480681 |
| SFTPA2 | surfactant protein A2 | 0.0478023 |
| RPL12 | ribosomal protein L12 | 0.0448562 |
| RPL26 | ribosomal protein L26 | 0.0436651 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0429699 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0429578 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0429321 |
| RPS6 | ribosomal protein S6 | 0.0426662 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0423991 |
| ZNF780B | zinc finger protein 780B | 0.0417389 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0416577 |
| AHNAK | AHNAK nucleoprotein | 0.0400311 |
| RPS17 | ribosomal protein S17 | 0.0398901 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0394297 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0386335 |
| RPLP2 | ribosomal protein, large, P2 | 0.0383283 |
| RPS4X | ribosomal protein S4, X-linked | 0.0382835 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0382691 |
| TAPBP | TAP binding protein (tapasin) | 0.0381488 |
| ANGPTL4 | angiopoietin-like 4 | 0.037438 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0372201 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0368538 |
| ASPH | aspartate beta-hydroxylase | 0.0366082 |
| CBX3 | chromobox homolog 3 | 0.0363908 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.036175 |
| RPL36 | ribosomal protein L36 | 0.0361258 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0355216 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0353889 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0353154 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0348958 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0346223 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0345324 |
| PFN1 | profilin 1 | 0.0338916 |
| RPS2 | ribosomal protein S2 | 0.0333 |
| CCDC88A | coiled-coil domain containing 88A | 0.0330429 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0330092 |
| CAVIN1 | caveolae associated protein 1 | 0.0327255 |
| LDHA | lactate dehydrogenase A | 0.0324567 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0323105 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0317289 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0309641 |
| ACTG1 | actin gamma 1 | 0.0308852 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0307847 |
| RPL30 | ribosomal protein L30 | 0.0307063 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0305135 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0304884 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0303375 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0303111 |
| PTK2 | protein tyrosine kinase 2 | 0.0302448 |
| GOLGB1 | golgin B1 | 0.0300098 |
| RPL19 | ribosomal protein L19 | 0.0300094 |
| RDX | radixin | 0.0298006 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0294052 |
| EHBP1 | EH domain binding protein 1 | 0.0292427 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0290498 |
| ANXA2 | annexin A2 | 0.0289816 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0287605 |
| DSTN | destrin (actin depolymerizing factor) | 0.0287477 |
| RPL37 | ribosomal protein L37 | 0.028409 |
| RPL18 | ribosomal protein L18 | 0.0283574 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0283331 |
| RPL11 | ribosomal protein L11 | 0.0282648 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0282072 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0280048 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.027933 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0276523 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0273475 |
| SET | SET nuclear proto-oncogene | 0.0271998 |
| SEPTIN7 | septin 7 | 0.0271926 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0269471 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS16 | ribosomal protein S16 | -0.103022 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0917065 |
| UBC | ubiquitin C | -0.0567664 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0521107 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0504222 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0483895 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0377226 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0361069 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0344389 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0343766 |
| MCL1 | myeloid cell leukemia 1 | -0.0343118 |
| CDK19 | cyclin-dependent kinase 19 | -0.0328056 |
| HM13 | histocompatibility (minor) 13 | -0.0308896 |
| USP34 | ubiquitin specific peptidase 34 | -0.0302809 |
| TMEM123 | transmembrane protein 123 | -0.0290413 |
| FOXO3 | forkhead box O3 | -0.0281167 |
| CTSD | cathepsin D | -0.0273277 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.026742 |
| ZNF292 | zinc finger protein 292 | -0.0266084 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0254268 |
| ZNF207 | zinc finger protein 207 | -0.0253892 |
| OGA | O-GlcNAcase | -0.0248916 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0233436 |
| CALR | calreticulin | -0.0229839 |
| SNX14 | sorting nexin 14 | -0.0229593 |
| FTL | ferritin, light polypeptide | -0.0224282 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0218056 |
| TXNRD1 | thioredoxin reductase 1 | -0.0217974 |
| YAP1 | Yes-associated protein 1 | -0.0213262 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.021286 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0210749 |
| RPS24 | ribosomal protein S24 | -0.0209414 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0203896 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.0202733 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0201885 |
| TMEM41B | transmembrane protein 41B | -0.0200764 |
| RTN4 | reticulon 4 | -0.0199551 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0198035 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0196708 |
| JMJD1C | jumonji domain containing 1C | -0.0194672 |
| RPL36A | ribosomal protein L36a | -0.0188963 |
| PTEN | phosphatase and tensin homolog | -0.0188917 |
| SPAG9 | sperm associated antigen 9 | -0.018804 |
| SUCO | SUN domain containing ossification factor | -0.0186066 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0184935 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0182763 |
| WDR45B | WD repeat domain 45B | -0.0180675 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0176522 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0175578 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0174322 |
| COPA | coatomer protein complex, subunit alpha | -0.0171634 |
| SEC24A | SEC24 family member A | -0.0170491 |
| NUP58 | nucleoporin 58 | -0.0170004 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0169258 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0167423 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0167072 |
| SEPTIN2 | septin 2 | -0.0166541 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0166238 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.016564 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0164812 |
| RPL39 | ribosomal protein L39 | -0.0164742 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0163496 |
| COG5 | component of oligomeric golgi complex 5 | -0.0163253 |
| RHEB | Ras homolog enriched in brain | -0.0161702 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0160652 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0160551 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0159875 |
| NUP153 | nucleoporin 153kDa | -0.0158357 |
| SRP54 | signal recognition particle 54kDa | -0.0157324 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0157114 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0155983 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.015532 |
| NUP160 | nucleoporin 160kDa | -0.0154597 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0153798 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0153764 |
| TFG | TRK-fused gene | -0.0152282 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0148744 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0147736 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.014757 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0147323 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0145813 |
| SMAD3 | SMAD family member 3 | -0.0145592 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0143423 |
| ARF4 | ADP-ribosylation factor 4 | -0.0143285 |
| FOXK2 | forkhead box K2 | -0.0143003 |
| MED13 | mediator complex subunit 13 | -0.0141313 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0141168 |
| EFNA5 | ephrin-A5 | -0.0140734 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0139316 |
| AFAP1 | actin filament associated protein 1 | -0.0139282 |
| RPLP1 | ribosomal protein, large, P1 | -0.0138052 |
| FOXJ3 | forkhead box J3 | -0.0137206 |
| SPG11 | spastic paraplegia 11 (autosomal recessive) | -0.0136778 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0136708 |
| CALU | calumenin | -0.0136646 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0136581 |
| NBAS | neuroblastoma amplified sequence | -0.0136119 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0135624 |
| TMEM39A | transmembrane protein 39A | -0.0133949 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0132856 |
