| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-7648_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.158615 |
| LAMB3 | laminin, beta 3 | 0.141343 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.110696 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.102147 |
| RPS3 | ribosomal protein S3 | 0.0953219 |
| INTS6 | integrator complex subunit 6 | 0.0731824 |
| GOLGB1 | golgin B1 | 0.0723032 |
| RPS6 | ribosomal protein S6 | 0.0722419 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0688643 |
| LMO7 | LIM domain 7 | 0.064641 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0642362 |
| RACK1 | receptor for activated C kinase 1 | 0.0595505 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0591533 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0565951 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0554179 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0536522 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.051954 |
| LAMC2 | laminin, gamma 2 | 0.0511741 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0501652 |
| FAM107B | family with sequence similarity 107, member B | 0.04733 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0462683 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0455565 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0441539 |
| AFDN | afadin, adherens junction formation factor | 0.0440534 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0436357 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0425377 |
| G0S2 | G0/G1 switch 2 | 0.0417123 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0416507 |
| FMNL2 | formin-like 2 | 0.0414252 |
| AHNAK | AHNAK nucleoprotein | 0.0406366 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0406298 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0404298 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.040291 |
| SQSTM1 | sequestosome 1 | 0.0391464 |
| BRD2 | bromodomain containing 2 | 0.0384455 |
| SMAD3 | SMAD family member 3 | 0.0383281 |
| TJP1 | tight junction protein 1 | 0.0381838 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.03664 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.036636 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0366076 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0365493 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0364136 |
| PTMA | prothymosin, alpha | 0.0362572 |
| RPL12 | ribosomal protein L12 | 0.035946 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0342707 |
| CENPF | centromere protein F, 350/400kDa | 0.0342062 |
| CANX | calnexin | 0.0339529 |
| BRD4 | bromodomain containing 4 | 0.0338931 |
| NAV2 | neuron navigator 2 | 0.0338076 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0329703 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.032651 |
| ARRDC3 | arrestin domain containing 3 | 0.0325011 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0323804 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0321726 |
| RPS8 | ribosomal protein S8 | 0.0321374 |
| RPL18 | ribosomal protein L18 | 0.0319877 |
| RPS12 | ribosomal protein S12 | 0.031162 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.03062 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0305581 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0305467 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0302549 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0301475 |
| SVIL | supervillin | 0.0300934 |
| LDHA | lactate dehydrogenase A | 0.0299218 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0297186 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.029562 |
| RPL14 | ribosomal protein L14 | 0.0290854 |
| DSPP | dentin sialophosphoprotein | 0.0287666 |
| TMSB4X | thymosin beta 4, X-linked | 0.0286046 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0283531 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0283216 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0283063 |
| AREG | amphiregulin | 0.0282312 |
| RPS2 | ribosomal protein S2 | 0.028103 |
| CD44 | CD44 molecule (Indian blood group) | 0.02808 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0277186 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0276016 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0274515 |
| TMF1 | TATA element modulatory factor 1 | 0.0273882 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0273204 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0266744 |
| FNIP1 | folliculin interacting protein 1 | 0.0264555 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.025925 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0258145 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0257896 |
| SON | SON DNA binding protein | 0.0257165 |
| EMP1 | epithelial membrane protein 1 | 0.0251877 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0251727 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0249404 |
| KLF6 | Kruppel-like factor 6 | 0.0247289 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0246228 |
| MKI67 | marker of proliferation Ki-67 | 0.0245693 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0241729 |
| RPL32 | ribosomal protein L32 | 0.0238318 |
| NDRG1 | N-myc downstream regulated 1 | 0.0236081 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0235739 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.023533 |
| RPS4X | ribosomal protein S4, X-linked | 0.0228282 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0225691 |
| DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides | 0.0222989 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC4 | mucin 4, cell surface associated | -0.183632 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.118942 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.110979 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.094432 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0932952 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.092552 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0803439 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0709228 |
| PLAT | plasminogen activator, tissue | -0.0671987 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0587235 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.057244 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0555484 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0514191 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0509961 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0495525 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.0483998 |
| HMGA1 | high mobility group AT-hook 1 | -0.0483854 |
| C3 | complement component 3 | -0.0481459 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0462171 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0459728 |
| KRT19 | keratin 19, type I | -0.0454414 |
| CD2AP | CD2-associated protein | -0.0448116 |
| MUC16 | mucin 16, cell surface associated | -0.0448096 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0443906 |
| MX2 | MX dynamin-like GTPase 2 | -0.0441838 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0440408 |
| HLA-A | major histocompatibility complex, class I, A | -0.042377 |
| HLA-E | major histocompatibility complex, class I, E | -0.0422918 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0419858 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0415689 |
| RUNX1 | runt-related transcription factor 1 | -0.0413952 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0408935 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0403711 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0396431 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0396036 |
| OXSR1 | oxidative stress responsive 1 | -0.0387758 |
| OSMR | oncostatin M receptor | -0.0382236 |
| TMEM123 | transmembrane protein 123 | -0.0379163 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0376287 |
| WWC1 | WW and C2 domain containing 1 | -0.0375854 |
| HLA-B | major histocompatibility complex, class I, B | -0.0361237 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0359934 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0353053 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0348052 |
| PKM | pyruvate kinase, muscle | -0.0345263 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0343922 |
| PARD3 | par-3 family cell polarity regulator | -0.033224 |
| KRT17 | keratin 17, type I | -0.0331678 |
| FNDC3B | fibronectin type III domain containing 3B | -0.033128 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0331024 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0326832 |
| HLA-C | major histocompatibility complex, class I, C | -0.0323429 |
| TC2N | tandem C2 domains, nuclear | -0.0320848 |
| NF1 | neurofibromin 1 | -0.0315767 |
| TMSB10 | thymosin beta 10 | -0.0313065 |
| RPLP1 | ribosomal protein, large, P1 | -0.0311338 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0304488 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0299665 |
| RNF213 | ring finger protein 213 | -0.0296662 |
| RPS25 | ribosomal protein S25 | -0.0295947 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.02956 |
| MYO1E | myosin IE | -0.029409 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0293618 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0293599 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.029272 |
| EFNA5 | ephrin-A5 | -0.029131 |
| CTSD | cathepsin D | -0.0286804 |
| SULF2 | sulfatase 2 | -0.0286168 |
| S100A6 | S100 calcium binding protein A6 | -0.0285073 |
| FTL | ferritin, light polypeptide | -0.028378 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0282853 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0279921 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0279828 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0277506 |
| FN1 | fibronectin 1 | -0.0275834 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0274462 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0269254 |
| RPS27 | ribosomal protein S27 | -0.0267627 |
| TGM2 | transglutaminase 2 | -0.0266013 |
| WDR45B | WD repeat domain 45B | -0.0265365 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0264761 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0263729 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0263466 |
| DUSP5 | dual specificity phosphatase 5 | -0.0262073 |
| AFAP1 | actin filament associated protein 1 | -0.0261069 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0259036 |
| RPL36A | ribosomal protein L36a | -0.0259023 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0255338 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0253079 |
| LAMA4 | laminin, alpha 4 | -0.0249525 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0249037 |
| JMJD1C | jumonji domain containing 1C | -0.0247473 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0247244 |
| TXNRD1 | thioredoxin reductase 1 | -0.0246502 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0246393 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0238839 |
| MX1 | MX dynamin-like GTPase 1 | -0.0237364 |
| TPM4 | tropomyosin 4 | -0.0235327 |
| RPL28 | ribosomal protein L28 | -0.0233212 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.02316 |
