AZD-7648_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.110519
EXT1 exostosin glycosyltransferase 1 0.0770088
SGMS2 sphingomyelin synthase 2 0.0748288
JMJD1C jumonji domain containing 1C 0.0557707
MCTP1 multiple C2 domains, transmembrane 1 0.0491434
CORO1C coronin, actin binding protein, 1C 0.0465023
FRMD6 FERM domain containing 6 0.0389932
CAPRIN2 caprin family member 2 0.038829
AKAP12 A kinase (PRKA) anchor protein 12 0.0367015
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0364061
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0356951
RCOR1 REST corepressor 1 0.0353625
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0339715
AGO2 argonaute RISC catalytic component 2 0.033896
MYH9 myosin, heavy chain 9, non-muscle 0.0304006
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0276442
TM4SF19 transmembrane 4 L six family member 19 0.0274603
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0273097
APLP2 amyloid beta (A4) precursor-like protein 2 0.0263394
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0258462
ZSWIM6 zinc finger, SWIM-type containing 6 0.0256206
MCL1 myeloid cell leukemia 1 0.0245423
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0242971
HSPA8 heat shock 70kDa protein 8 0.0241838
BRD2 bromodomain containing 2 0.0233241
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0231194
UPP1 uridine phosphorylase 1 0.0229272
FNIP1 folliculin interacting protein 1 0.0227921
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0221699
BHLHE40 basic helix-loop-helix family, member e40 0.0219848
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.02192
ANK2 ankyrin 2, neuronal 0.021644
RAB7A RAB7A, member RAS oncogene family 0.0205855
ZEB1 zinc finger E-box binding homeobox 1 0.0200932
GLRX glutaredoxin (thioltransferase) 0.0199385
SQSTM1 sequestosome 1 0.0197612
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0195775
RPS2 ribosomal protein S2 0.0192386
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0191995
NAV2 neuron navigator 2 0.0190966
CD68 CD68 molecule 0.0188181
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0186338
RPL3 ribosomal protein L3 0.0178199
POTEF POTE ankyrin domain family, member F 0.0175494
DRC9 dynein regulatory complex subunit 9 0.0173824
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0168134
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0167701
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0166769
SPRED2 sprouty-related, EVH1 domain containing 2 0.0165172
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0164218
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0162271
ZBTB38 zinc finger and BTB domain containing 38 0.016065
RPS18 ribosomal protein S18 0.0158572
RUNX1 runt-related transcription factor 1 0.0154874
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0154346
ARHGAP31 Rho GTPase activating protein 31 0.0153145
INTS6 integrator complex subunit 6 0.0150347
TRIP12 thyroid hormone receptor interactor 12 0.0148465
SMAD3 SMAD family member 3 0.0147254
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0146958
PRELID2 PRELI domain containing 2 0.0146767
RPL14 ribosomal protein L14 0.0140085
ADTRP androgen-dependent TFPI-regulating protein 0.0136609
LRMDA leucine rich melanocyte differentiation associated 0.0134647
SFTPA2 surfactant protein A2 0.0134036
DDIT3 DNA-damage-inducible transcript 3 0.0129941
FBXL17 F-box and leucine-rich repeat protein 17 0.012914
ANO6 anoctamin 6 0.0128816
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0128519
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0127731
PLAUR plasminogen activator, urokinase receptor 0.0127362
KDM6B lysine (K)-specific demethylase 6B 0.0125797
GOLGB1 golgin B1 0.0124405
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0123295
ATP13A3 ATPase type 13A3 0.0121908
PDE4D phosphodiesterase 4D, cAMP-specific 0.0121325
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.012132
SHB Src homology 2 domain containing adaptor protein B 0.0120339
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0119949
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.011862
TRIB1 tribbles pseudokinase 1 0.0117709
KDM6A lysine (K)-specific demethylase 6A 0.0116992
FAM107B family with sequence similarity 107, member B 0.0116484
MYO9A myosin IXA 0.0116053
ARL15 ADP-ribosylation factor-like 15 0.0114693
CLIP1 CAP-GLY domain containing linker protein 1 0.0114273
IER2 immediate early response 2 0.0112749
ZFP36 ZFP36 ring finger protein 0.011216
BICD1 bicaudal D homolog 1 (Drosophila) 0.0111823
RBM12 RNA binding motif protein 12 0.0111723
FLNA filamin A, alpha 0.0111351
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0110998
JARID2 jumonji, AT rich interactive domain 2 0.0110686
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0110268
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0109985
BCAP31 B-cell receptor-associated protein 31 0.0108706
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0108052
CRYM crystallin, mu 0.0108002
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0107888
RPS3A ribosomal protein S3A 0.0107826

decreased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein -0.268518
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.152884
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.109833
TTR transthyretin -0.0986077
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0985473
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0966203
ZNF438 zinc finger protein 438 -0.0959242
CALD1 caldesmon 1 -0.0805885
MT2A metallothionein 2A -0.075071
LPP LIM domain containing preferred translocation partner in lipoma -0.0748493
NAV3 neuron navigator 3 -0.0687086
TRIO trio Rho guanine nucleotide exchange factor -0.0677605
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0621233
TPM4 tropomyosin 4 -0.0601396
PTK2 protein tyrosine kinase 2 -0.0587107
HMGA1 high mobility group AT-hook 1 -0.0566502
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0553193
NAP1L1 nucleosome assembly protein 1-like 1 -0.0552013
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0551345
HMGA2 high mobility group AT-hook 2 -0.0544197
IFI16 interferon, gamma-inducible protein 16 -0.0543282
LAMB3 laminin, beta 3 -0.054174
EEF2 eukaryotic translation elongation factor 2 -0.0525796
MTDH metadherin -0.0520181
PCNX4 pecanex 4 -0.0519706
RPL8 ribosomal protein L8 -0.0512005
TCF12 transcription factor 12 -0.0505999
BIRC6 baculoviral IAP repeat containing 6 -0.049054
ANTXR2 anthrax toxin receptor 2 -0.0456781
CANX calnexin -0.045393
RPL7A ribosomal protein L7a -0.0450622
PDIA3 protein disulfide isomerase family A, member 3 -0.044701
FRMD4A FERM domain containing 4A -0.0442434
RPL12 ribosomal protein L12 -0.0429106
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0428629
GNAS GNAS complex locus -0.0420108
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0419996
NF1 neurofibromin 1 -0.0417804
BNC2 basonuclin 2 -0.0408407
DIAPH3 diaphanous-related formin 3 -0.0402795
CDK6 cyclin-dependent kinase 6 -0.040259
NABP1 nucleic acid binding protein 1 -0.0399481
PGK1 phosphoglycerate kinase 1 -0.0396526
GOLGA4 golgin A4 -0.0396505
RPL30 ribosomal protein L30 -0.0393206
SAMD12 sterile alpha motif domain containing 12 -0.0393197
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0390074
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0389506
RPL35A ribosomal protein L35a -0.0382967
RPLP1 ribosomal protein, large, P1 -0.0376052
PTMA prothymosin, alpha -0.03745
SRPK2 SRSF protein kinase 2 -0.037261
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0361558
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0361262
PBX3 pre-B-cell leukemia homeobox 3 -0.0348325
RPS6 ribosomal protein S6 -0.0345959
KPNB1 karyopherin (importin) beta 1 -0.0345443
STC1 stanniocalcin 1 -0.0342322
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0338973
SETD5 SET domain containing 5 -0.0336497
SRPK1 SRSF protein kinase 1 -0.0333195
ANXA2 annexin A2 -0.0331877
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.032238
RPLP2 ribosomal protein, large, P2 -0.0321102
NUP58 nucleoporin 58 -0.0318404
FTL ferritin, light polypeptide -0.0317006
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0316216
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.031231
RAD21 RAD21 homolog (S. pombe) -0.0310332
CD274 CD274 molecule -0.0308973
RPS19 ribosomal protein S19 -0.0308424
RPL37A ribosomal protein L37a -0.0307743
ZBTB20 zinc finger and BTB domain containing 20 -0.0307111
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0304361
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.030223
PKM pyruvate kinase, muscle -0.0301088
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.029663
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0296186
TMSB10 thymosin beta 10 -0.0295436
RAB3IP RAB3A interacting protein -0.0294299
RPS24 ribosomal protein S24 -0.0292079
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0290929
RBM25 RNA binding motif protein 25 -0.0288113
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0287922
RPLP0 ribosomal protein, large, P0 -0.028767
RPS5 ribosomal protein S5 -0.0287423
OLA1 Obg-like ATPase 1 -0.0287167
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0282319
ZFAND3 zinc finger, AN1-type domain 3 -0.0281616
RPS20 ribosomal protein S20 -0.0279051
RPS27A ribosomal protein S27a -0.0277685
RPS29 ribosomal protein S29 -0.0272636
MTAP methylthioadenosine phosphorylase -0.0271061
OSBPL8 oxysterol binding protein-like 8 -0.0267945
RPL5 ribosomal protein L5 -0.0265563
SLC38A2 solute carrier family 38, member 2 -0.0265448
DENND1A DENN/MADD domain containing 1A -0.0264602
RPS25 ribosomal protein S25 -0.0263519
EIF5B eukaryotic translation initiation factor 5B -0.0263518
ALCAM activated leukocyte cell adhesion molecule -0.025672