| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.192156 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0997685 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0944182 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0776097 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0664755 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0608844 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0601335 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0595856 |
| B2M | beta-2-microglobulin | 0.0593857 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.057985 |
| IL1B | interleukin 1, beta | 0.0576096 |
| HDAC9 | histone deacetylase 9 | 0.0559039 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0532481 |
| CD44 | CD44 molecule (Indian blood group) | 0.0507702 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0507665 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0502513 |
| SMAD3 | SMAD family member 3 | 0.0497414 |
| FAT1 | FAT atypical cadherin 1 | 0.046037 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0447464 |
| COL5A1 | collagen, type V, alpha 1 | 0.0437582 |
| SP100 | SP100 nuclear antigen | 0.0420824 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0416179 |
| FAM107B | family with sequence similarity 107, member B | 0.0391971 |
| LOXL2 | lysyl oxidase-like 2 | 0.0390724 |
| CDCP1 | CUB domain containing protein 1 | 0.0388494 |
| ASPH | aspartate beta-hydroxylase | 0.0387959 |
| VEGFA | vascular endothelial growth factor A | 0.0387042 |
| RUNX1 | runt-related transcription factor 1 | 0.0385235 |
| ANXA2 | annexin A2 | 0.038316 |
| SVIL | supervillin | 0.0379056 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0376351 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0370075 |
| MTSS1 | metastasis suppressor 1 | 0.0369807 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0369282 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0355061 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0353992 |
| IFI44L | interferon-induced protein 44-like | 0.0352906 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0347137 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0343293 |
| GOLGB1 | golgin B1 | 0.0342324 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0339759 |
| ARRDC3 | arrestin domain containing 3 | 0.0339259 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0335943 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0334085 |
| DST | dystonin | 0.0333758 |
| ANGPTL4 | angiopoietin-like 4 | 0.033359 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0328281 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0322732 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.031899 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0317346 |
| CTSB | cathepsin B | 0.0309888 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0300652 |
| BRD2 | bromodomain containing 2 | 0.0299615 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.029184 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0287237 |
| COL5A3 | collagen, type V, alpha 3 | 0.0285494 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0281682 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.02772 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0269834 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0269151 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0267 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0266687 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.026595 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0264951 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0259494 |
| FLNB | filamin B, beta | 0.0258142 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0257636 |
| AFDN | afadin, adherens junction formation factor | 0.0256205 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0253298 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0248909 |
| FNIP1 | folliculin interacting protein 1 | 0.0246846 |
| MYO9A | myosin IXA | 0.0246732 |
| PCBP3 | poly(rC) binding protein 3 | 0.0246065 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.024468 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0244239 |
| H1-0 | H1.0 linker histone | 0.024152 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0239641 |
| JUN | jun proto-oncogene | 0.0239118 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0236038 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0234064 |
| PLSCR1 | phospholipid scramblase 1 | 0.023377 |
| TMF1 | TATA element modulatory factor 1 | 0.023361 |
| TAPBP | TAP binding protein (tapasin) | 0.0233385 |
| ADAR | adenosine deaminase, RNA-specific | 0.0231183 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0230957 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.022811 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0227302 |
| RND3 | Rho family GTPase 3 | 0.0222005 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0219818 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0207828 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0207697 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0204934 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0203125 |
| YBX1 | Y box binding protein 1 | 0.0202446 |
| EMP1 | epithelial membrane protein 1 | 0.0202049 |
| LDHA | lactate dehydrogenase A | 0.0198402 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0196154 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.019527 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0194695 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0193325 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.247653 |
| FN1 | fibronectin 1 | -0.234981 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.100978 |
| FTL | ferritin, light polypeptide | -0.0933973 |
| COL1A1 | collagen, type I, alpha 1 | -0.0913692 |
| COL1A2 | collagen, type I, alpha 2 | -0.0722762 |
| TPM4 | tropomyosin 4 | -0.0617447 |
| PKM | pyruvate kinase, muscle | -0.039329 |
| CDH13 | cadherin 13 | -0.0389587 |
| TMSB10 | thymosin beta 10 | -0.0374766 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0374328 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0358945 |
| POTEF | POTE ankyrin domain family, member F | -0.0358398 |
| PGK1 | phosphoglycerate kinase 1 | -0.0345164 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0335723 |
| RPLP1 | ribosomal protein, large, P1 | -0.0308899 |
| FRMD4A | FERM domain containing 4A | -0.030824 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0305529 |
| FBXO11 | F-box protein 11 | -0.0301309 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0294314 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0272374 |
| RPS25 | ribosomal protein S25 | -0.0267353 |
| SETD5 | SET domain containing 5 | -0.0257145 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0250846 |
| GNAS | GNAS complex locus | -0.0250701 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0250463 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.024491 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0242818 |
| RPL35A | ribosomal protein L35a | -0.0241315 |
| TNS3 | tensin 3 | -0.0226588 |
| THBS1 | thrombospondin 1 | -0.0223693 |
| CENPF | centromere protein F, 350/400kDa | -0.0222829 |
| NREP | neuronal regeneration related protein | -0.0222648 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0220993 |
| PTMA | prothymosin, alpha | -0.0219722 |
| RTN4 | reticulon 4 | -0.0218583 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0215013 |
| RPL31 | ribosomal protein L31 | -0.0213372 |
| TPM1 | tropomyosin 1 (alpha) | -0.0209997 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0206387 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0206078 |
| HM13 | histocompatibility (minor) 13 | -0.0204535 |
| HLA-B | major histocompatibility complex, class I, B | -0.0203576 |
| HLA-C | major histocompatibility complex, class I, C | -0.0203168 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.0202495 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0199742 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0196914 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.019444 |
| VCAN | versican | -0.0193825 |
| ITGAV | integrin, alpha V | -0.018999 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0188103 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0180955 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0180342 |
| CTSD | cathepsin D | -0.0180248 |
| TPX2 | TPX2, microtubule-associated | -0.0179538 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0179522 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0177136 |
| MKI67 | marker of proliferation Ki-67 | -0.0175147 |
| ZNF609 | zinc finger protein 609 | -0.0173122 |
| PTGFR | prostaglandin F receptor (FP) | -0.0172512 |
| TNNC1 | troponin C type 1 (slow) | -0.0172475 |
| ERBIN | erbb2 interacting protein | -0.0172314 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0171812 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0171493 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0171089 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0170143 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0170125 |
| RPS29 | ribosomal protein S29 | -0.0169488 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0169028 |
| MMP12 | matrix metallopeptidase 12 | -0.0168666 |
| DIAPH3 | diaphanous-related formin 3 | -0.0168493 |
| RUNX2 | runt-related transcription factor 2 | -0.0167829 |
| RPS21 | ribosomal protein S21 | -0.0167071 |
| TMEM165 | transmembrane protein 165 | -0.0166698 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0165952 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.016546 |
| TUBB | tubulin, beta class I | -0.0164884 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0163777 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0163769 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0162469 |
| HMGA1 | high mobility group AT-hook 1 | -0.0162054 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0161594 |
| COLEC10 | collectin sub-family member 10 (C-type lectin) | -0.0160703 |
| RRBP1 | ribosome binding protein 1 | -0.0160186 |
| COL5A2 | collagen, type V, alpha 2 | -0.0160185 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.015929 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0158242 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0158033 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0157066 |
| SNX14 | sorting nexin 14 | -0.0156575 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0156463 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0156367 |
| USP3 | ubiquitin specific peptidase 3 | -0.0156084 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0155644 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0155334 |
| PRSS23 | protease, serine, 23 | -0.0155071 |
| RPS13 | ribosomal protein S13 | -0.0154664 |
| S100A6 | S100 calcium binding protein A6 | -0.0154623 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.01532 |
| AAK1 | AP2 associated kinase 1 | -0.0152943 |
