| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-7648_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INHBA | inhibin, beta A | 0.0896388 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0705599 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0623025 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0613842 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0590835 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0490253 |
| ASPH | aspartate beta-hydroxylase | 0.0455649 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0423394 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0420662 |
| ZFHX3 | zinc finger homeobox 3 | 0.0397771 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0395823 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0384379 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0377824 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0373323 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0367772 |
| MCL1 | myeloid cell leukemia 1 | 0.0359472 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0345833 |
| ADAR | adenosine deaminase, RNA-specific | 0.0336415 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0326199 |
| SCG2 | secretogranin II | 0.0309633 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.0306243 |
| RPS12 | ribosomal protein S12 | 0.0300572 |
| FTL | ferritin, light polypeptide | 0.029973 |
| TOX | thymocyte selection-associated high mobility group box | 0.0294982 |
| DST | dystonin | 0.0293566 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0283682 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0282652 |
| RACK1 | receptor for activated C kinase 1 | 0.0279544 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0275262 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0274489 |
| TPM3 | tropomyosin 3 | 0.0271686 |
| CHGB | chromogranin B | 0.0264931 |
| RPS3 | ribosomal protein S3 | 0.0263415 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0248022 |
| SIK2 | salt-inducible kinase 2 | 0.0247216 |
| FAT1 | FAT atypical cadherin 1 | 0.0244976 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0237728 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0236316 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0235289 |
| TRIM9 | tripartite motif containing 9 | 0.0233115 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0232466 |
| BRD2 | bromodomain containing 2 | 0.0217886 |
| EGFR | epidermal growth factor receptor | 0.0216254 |
| RPS8 | ribosomal protein S8 | 0.0215151 |
| NBEA | neurobeachin | 0.0212316 |
| SETX | senataxin | 0.0211357 |
| RPL37 | ribosomal protein L37 | 0.020317 |
| RALYL | RALY RNA binding protein-like | 0.0203111 |
| AHR | aryl hydrocarbon receptor | 0.0201368 |
| NRXN1 | neurexin 1 | 0.0201322 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0200079 |
| EP400 | E1A binding protein p400 | 0.0195688 |
| NFIB | nuclear factor I/B | 0.0195407 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.019412 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0191922 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.019179 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0190467 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0189897 |
| MT2A | metallothionein 2A | 0.0189227 |
| RPS21 | ribosomal protein S21 | 0.01869 |
| CALR | calreticulin | 0.0185064 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0181992 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.018081 |
| GOLGB1 | golgin B1 | 0.0180193 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0180171 |
| IRS2 | insulin receptor substrate 2 | 0.0179933 |
| VCL | vinculin | 0.017921 |
| RPS2 | ribosomal protein S2 | 0.0179078 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.017816 |
| RPL37A | ribosomal protein L37a | 0.0177128 |
| RPL14 | ribosomal protein L14 | 0.0176065 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0175477 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0174955 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0174201 |
| ELMO1 | engulfment and cell motility 1 | 0.0173562 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.017345 |
| YBX1 | Y box binding protein 1 | 0.0172674 |
| FERMT2 | fermitin family member 2 | 0.0166689 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0164294 |
| HOMER1 | homer scaffolding protein 1 | 0.0164093 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0163861 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0163547 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0162825 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0162548 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0162341 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0162181 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0161777 |
| GRM8 | glutamate receptor, metabotropic 8 | 0.0161722 |
| TOX3 | TOX high mobility group box family member 3 | 0.0161646 |
| MX2 | MX dynamin-like GTPase 2 | 0.0161605 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0160916 |
| AATF | apoptosis antagonizing transcription factor | 0.0160252 |
| PRKD1 | protein kinase D1 | 0.015999 |
| SET | SET nuclear proto-oncogene | 0.0159734 |
| EPHA4 | EPH receptor A4 | 0.0158269 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0157762 |
| SMAD9 | SMAD family member 9 | 0.0157606 |
| SP100 | SP100 nuclear antigen | 0.0156877 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0156845 |
| HYOU1 | hypoxia up-regulated 1 | 0.0156367 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CALCA | calcitonin-related polypeptide alpha | -0.113817 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.082531 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.079393 |
| FGF14 | fibroblast growth factor 14 | -0.0769799 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0761628 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0689323 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0685479 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0636928 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0623415 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0620216 |
| TENM1 | teneurin transmembrane protein 1 | -0.0620211 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0619844 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0577473 |
| PTMA | prothymosin, alpha | -0.0569972 |
| PEG10 | paternally expressed 10 | -0.0566383 |
| NRG1 | neuregulin 1 | -0.0554844 |
| SLC35F4 | solute carrier family 35, member F4 | -0.0515588 |
| DTNA | dystrobrevin, alpha | -0.0511695 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0463277 |
| GPC5 | glypican 5 | -0.0452399 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.043871 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.041983 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0416877 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0416363 |
| ESRRG | estrogen-related receptor gamma | -0.0381752 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0343288 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0342594 |
| MMP26 | matrix metallopeptidase 26 | -0.0334194 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0334152 |
| CENPF | centromere protein F, 350/400kDa | -0.0331181 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0323058 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.0314107 |
| NCAM1 | neural cell adhesion molecule 1 | -0.030954 |
| IGF1R | insulin-like growth factor 1 receptor | -0.030217 |
| MKI67 | marker of proliferation Ki-67 | -0.0295931 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0292552 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.029237 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0290503 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0285852 |
| ACTG1 | actin gamma 1 | -0.0285576 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0282811 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0279725 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0279031 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0274027 |
| TMSB4X | thymosin beta 4, X-linked | -0.026682 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0263395 |
| CADM1 | cell adhesion molecule 1 | -0.0262909 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0257742 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0254853 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0252347 |
| GPC6 | glypican 6 | -0.0247551 |
| RORA | RAR-related orphan receptor A | -0.0247525 |
| MSI2 | musashi RNA-binding protein 2 | -0.0247442 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0246179 |
| ZNF609 | zinc finger protein 609 | -0.0245348 |
| GPHN | gephyrin | -0.0244973 |
| WDR45B | WD repeat domain 45B | -0.0244773 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0242472 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0242162 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0241029 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0240052 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0237595 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0237553 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0235788 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0235643 |
| S100A9 | S100 calcium binding protein A9 | -0.0234234 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0232033 |
| NDRG1 | N-myc downstream regulated 1 | -0.0231438 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | -0.0231179 |
| STC1 | stanniocalcin 1 | -0.0229413 |
| IGF2 | insulin-like growth factor 2 | -0.0228469 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0227738 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0227573 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0226695 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0225776 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.022371 |
| ECT2 | epithelial cell transforming 2 | -0.0223621 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0223106 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0221371 |
| GNAS | GNAS complex locus | -0.0220739 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0220397 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0219844 |
| RPS25 | ribosomal protein S25 | -0.0219594 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0219426 |
| AURKA | aurora kinase A | -0.0214483 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0213892 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.02137 |
| DIAPH3 | diaphanous-related formin 3 | -0.0211634 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0210964 |
| PTCHD4 | patched domain containing 4 | -0.0208943 |
| PARD3 | par-3 family cell polarity regulator | -0.0208128 |
| CPE | carboxypeptidase E | -0.0207691 |
| FRY | furry homolog (Drosophila) | -0.0205803 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.0204726 |
| KNL1 | kinetochore scaffold 1 | -0.0204175 |
| SRPK2 | SRSF protein kinase 2 | -0.0203568 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | -0.0202925 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0202547 |
| TNRC6C | trinucleotide repeat containing 6C | -0.0201242 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0199635 |
