AZD-7648_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.193132
FMN1 formin 1 0.121384
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106641
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.100809
RPS3 ribosomal protein S3 0.0961479
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0872367
SFTPA2 surfactant protein A2 0.0822969
ANGPTL4 angiopoietin-like 4 0.0815884
CCND1 cyclin D1 0.0737579
MT2A metallothionein 2A 0.0697324
VIM vimentin 0.0682997
CD44 CD44 molecule (Indian blood group) 0.0642972
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.061368
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0595758
TM4SF1 transmembrane 4 L six family member 1 0.0569035
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0532286
HSPA8 heat shock 70kDa protein 8 0.0518431
BHLHE40 basic helix-loop-helix family, member e40 0.0515178
MSN moesin 0.0503052
CTSB cathepsin B 0.0501757
MYH9 myosin, heavy chain 9, non-muscle 0.0496755
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0473653
B2M beta-2-microglobulin 0.0460625
LDHA lactate dehydrogenase A 0.0453753
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0448315
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0445125
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0431514
AHNAK AHNAK nucleoprotein 0.0429579
ENO1 enolase 1, (alpha) 0.0396668
IGFBP3 insulin-like growth factor binding protein 3 0.0396271
WWTR1 WW domain containing transcription regulator 1 0.0390427
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0385419
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0382963
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0379876
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.037329
DST dystonin 0.0367136
CDK6 cyclin-dependent kinase 6 0.036341
MKI67 marker of proliferation Ki-67 0.0357592
AMOTL1 angiomotin like 1 0.0357306
SMAD3 SMAD family member 3 0.035512
RUNX1 runt-related transcription factor 1 0.0352794
ICAM1 intercellular adhesion molecule 1 0.0347863
ALCAM activated leukocyte cell adhesion molecule 0.0342307
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0336664
RPS6 ribosomal protein S6 0.0335914
RPS4X ribosomal protein S4, X-linked 0.032937
ANXA2 annexin A2 0.0325198
TPM3 tropomyosin 3 0.0320435
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0320014
ASPH aspartate beta-hydroxylase 0.0317653
NFE2L1 nuclear factor, erythroid 2-like 1 0.0314699
PKM pyruvate kinase, muscle 0.0314215
EMP1 epithelial membrane protein 1 0.0311424
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0310353
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0308505
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0307815
FNDC3B fibronectin type III domain containing 3B 0.0306245
KLF6 Kruppel-like factor 6 0.0304043
PRRC2C proline-rich coiled-coil 2C 0.0302124
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0299746
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0296262
GOLGB1 golgin B1 0.0292796
CORO1C coronin, actin binding protein, 1C 0.0292404
CD59 CD59 molecule, complement regulatory protein 0.0288917
RACK1 receptor for activated C kinase 1 0.028337
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.028298
ACTN1 actinin, alpha 1 0.028128
SH3KBP1 SH3-domain kinase binding protein 1 0.0280778
PGK1 phosphoglycerate kinase 1 0.027959
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0269535
CXCL8 chemokine (C-X-C motif) ligand 8 0.0267827
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.026592
NAP1L1 nucleosome assembly protein 1-like 1 0.0263112
KTN1 kinectin 1 (kinesin receptor) 0.0263054
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0260714
ANXA5 annexin A5 0.0253318
ZBTB38 zinc finger and BTB domain containing 38 0.0253234
HSPA4 heat shock 70kDa protein 4 0.0252309
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0249717
YBX3 Y box binding protein 3 0.0249427
TRIO trio Rho guanine nucleotide exchange factor 0.0247967
DUSP6 dual specificity phosphatase 6 0.0245582
NDRG1 N-myc downstream regulated 1 0.0243888
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.024306
BCAP31 B-cell receptor-associated protein 31 0.024094
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.024058
CTTN cortactin 0.0240077
DIAPH1 diaphanous-related formin 1 0.0238946
EZR ezrin 0.023617
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0235891
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0235322
IQGAP1 IQ motif containing GTPase activating protein 1 0.0234758
CANX calnexin 0.0233588
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0233323
IPO7 importin 7 0.0232105
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0230019
CENPF centromere protein F, 350/400kDa 0.0229742
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0229371
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.022936
NAV2 neuron navigator 2 0.0228021

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.194295
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.186152
NLGN1 neuroligin 1 -0.155295
FRMD4A FERM domain containing 4A -0.0758734
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0630179
CADM1 cell adhesion molecule 1 -0.0482799
MARCHF1 membrane associated ring-CH-type finger 1 -0.0444279
MSI2 musashi RNA-binding protein 2 -0.0425735
FHIT fragile histidine triad -0.0421369
SREBF2 sterol regulatory element binding transcription factor 2 -0.0414111
FTL ferritin, light polypeptide -0.0403476
RAD51B RAD51 paralog B -0.0386092
PTPRM protein tyrosine phosphatase, receptor type, M -0.0372944
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0372914
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0354138
SMYD3 SET and MYND domain containing 3 -0.0340122
BCAS3 breast carcinoma amplified sequence 3 -0.0335895
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0324599
SBF2 SET binding factor 2 -0.0322871
ZCCHC7 zinc finger, CCHC domain containing 7 -0.031758
FN1 fibronectin 1 -0.0308879
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0301253
BIRC6 baculoviral IAP repeat containing 6 -0.0298877
PDZRN3 PDZ domain containing ring finger 3 -0.0297747
TNNC1 troponin C type 1 (slow) -0.0296716
ZBTB20 zinc finger and BTB domain containing 20 -0.028484
GOLGA4 golgin A4 -0.028132
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0280361
SLC39A11 solute carrier family 39, member 11 -0.027878
RAB7A RAB7A, member RAS oncogene family -0.0277256
TTC3 tetratricopeptide repeat domain 3 -0.027126
ZNF292 zinc finger protein 292 -0.0270501
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0269916
ANKRD17 ankyrin repeat domain 17 -0.0266123
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0253905
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0252665
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0248475
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.024643
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0234457
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0232726
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0230199
MFSD12 major facilitator superfamily domain containing 12 -0.0227756
NHSL1 NHS-like 1 -0.022645
ZFAND3 zinc finger, AN1-type domain 3 -0.0226313
MACROD2 MACRO domain containing 2 -0.0224206
DLG1 discs, large homolog 1 (Drosophila) -0.0222111
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0220213
CLEC2D C-type lectin domain family 2, member D -0.0211638
EHBP1 EH domain binding protein 1 -0.0211417
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0209243
WDPCP WD repeat containing planar cell polarity effector -0.0206159
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0202899
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.020284
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0202047
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0200237
IARS1 isoleucyl-tRNA synthetase 1 -0.0200053
SOX5 SRY (sex determining region Y)-box 5 -0.0199935
ENAH enabled homolog (Drosophila) -0.0195675
AUTS2 autism susceptibility candidate 2 -0.0195403
MBNL1 muscleblind-like splicing regulator 1 -0.0195286
VDAC1 voltage-dependent anion channel 1 -0.0194639
SRPK2 SRSF protein kinase 2 -0.0191164
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0178882
LCORL ligand dependent nuclear receptor corepressor-like -0.01779
MON2 MON2 homolog (S. cerevisiae) -0.0177652
ARMC9 armadillo repeat containing 9 -0.0177253
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0172031
DIAPH2 diaphanous-related formin 2 -0.0171805
HSPG2 heparan sulfate proteoglycan 2 -0.0171257
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0169928
OGA O-GlcNAcase -0.0167923
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0167652
CTSD cathepsin D -0.0167646
TFRC transferrin receptor -0.0166775
GPHN gephyrin -0.0166331
HELZ helicase with zinc finger -0.0165592
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0165118
GPR137B G protein-coupled receptor 137B -0.0163748
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0163506
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -0.0162873
ADAM17 ADAM metallopeptidase domain 17 -0.0161681
RBM39 RNA binding motif protein 39 -0.0161449
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0161007
GRB10 growth factor receptor-bound protein 10 -0.0160685
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0160046
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0158912
TRIQK triple QxxK/R motif containing -0.0158572
KAZN kazrin, periplakin interacting protein -0.0158147
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0157946
PHTF1 putative homeodomain transcription factor 1 -0.0156853
FTO fat mass and obesity associated -0.0156739
PRAME preferentially expressed antigen in melanoma -0.015649
STRN3 striatin, calmodulin binding protein 3 -0.015647
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.0156098
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0155825
EXOC4 exocyst complex component 4 -0.015511
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0154168
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0151541
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0151468
PNISR PNN-interacting serine/arginine-rich protein -0.0150797