AZD-7648_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.173377
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0680341
RPS6 ribosomal protein S6 0.0664081
RPS8 ribosomal protein S8 0.0511605
HDAC9 histone deacetylase 9 0.0488768
FER1L6 fer-1-like family member 6 0.0438632
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0438604
MKI67 marker of proliferation Ki-67 0.0425336
MACROD2 MACRO domain containing 2 0.0425143
RPS3 ribosomal protein S3 0.0421146
ANXA1 annexin A1 0.0386334
BRD2 bromodomain containing 2 0.0381565
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0361282
BMP10 bone morphogenetic protein 10 0.0359813
ZNF608 zinc finger protein 608 0.0359644
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0353654
RPS2 ribosomal protein S2 0.0310696
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0306618
DUSP4 dual specificity phosphatase 4 0.0302201
CENPF centromere protein F, 350/400kDa 0.030111
APLP2 amyloid beta (A4) precursor-like protein 2 0.0294667
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0278614
RPL14 ribosomal protein L14 0.0276598
MYO5C myosin VC 0.0268092
SOX9 SRY (sex determining region Y)-box 9 0.0258702
RPS17 ribosomal protein S17 0.025587
RPL37A ribosomal protein L37a 0.0254601
HSPA8 heat shock 70kDa protein 8 0.0250181
RRM2 ribonucleotide reductase M2 0.0248847
LOC102724023 ES1 protein homolog, mitochondrial 0.0245948
RFC3 replication factor C (activator 1) 3, 38kDa 0.0237246
H1-4 H1.4 linker histone, cluster member 0.0235458
IFI16 interferon, gamma-inducible protein 16 0.0229882
INTS6 integrator complex subunit 6 0.0229553
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0228795
TACC2 transforming, acidic coiled-coil containing protein 2 0.022831
AKAP12 A kinase (PRKA) anchor protein 12 0.0228158
PTMA prothymosin, alpha 0.0224944
DST dystonin 0.0222268
NAV2 neuron navigator 2 0.0221985
RPL18 ribosomal protein L18 0.0218988
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0214873
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0214177
VIM vimentin 0.0213342
SOX6 SRY (sex determining region Y)-box 6 0.0213121
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0212924
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0211252
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0204789
RPS12 ribosomal protein S12 0.020361
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0203555
EZR ezrin 0.0202091
TM4SF1 transmembrane 4 L six family member 1 0.0200346
ANLN anillin, actin binding protein 0.0200144
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0198965
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0198672
NFE2L1 nuclear factor, erythroid 2-like 1 0.0197281
RPLP2 ribosomal protein, large, P2 0.0196949
TSC22D1 TSC22 domain family, member 1 0.0193978
SMC4 structural maintenance of chromosomes 4 0.0190845
RPL7 ribosomal protein L7 0.0188256
ZSWIM6 zinc finger, SWIM-type containing 6 0.0187002
SRRM2 serine/arginine repetitive matrix 2 0.0186385
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0185818
CREBBP CREB binding protein 0.0185336
ENO2 enolase 2 (gamma, neuronal) 0.0184537
CEP128 centrosomal protein 128kDa 0.0179906
CORO1C coronin, actin binding protein, 1C 0.0178506
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.0176815
ARHGAP25 Rho GTPase activating protein 25 0.0176209
ASPH aspartate beta-hydroxylase 0.0175937
SPRY2 sprouty homolog 2 (Drosophila) 0.0174553
EIF1 eukaryotic translation initiation factor 1 0.0174459
GLI3 GLI family zinc finger 3 0.0172022
TUBB4B tubulin, beta 4B class IVb 0.0170561
POTEF POTE ankyrin domain family, member F 0.0170263
FAT1 FAT atypical cadherin 1 0.0168877
JUN jun proto-oncogene 0.01674
MYH9 myosin, heavy chain 9, non-muscle 0.0163972
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.016367
EEF1G eukaryotic translation elongation factor 1 gamma 0.0162881
ITGA6 integrin, alpha 6 0.0160648
RPL9 ribosomal protein L9 0.0160413
ERRFI1 ERBB receptor feedback inhibitor 1 0.0160373
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0158646
ANXA3 annexin A3 0.0158238
RPS18 ribosomal protein S18 0.0157219
RPS10 ribosomal protein S10 0.0156852
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0154347
SDK1 sidekick cell adhesion molecule 1 0.015368
RPL19 ribosomal protein L19 0.0153278
SON SON DNA binding protein 0.0152754
SEPTIN9 septin 9 0.0151332
AEBP2 AE binding protein 2 0.0150538
BRD4 bromodomain containing 4 0.0150535
RPL36 ribosomal protein L36 0.0148716
DDIT3 DNA-damage-inducible transcript 3 0.0148319
ATAD2 ATPase family, AAA domain containing 2 0.014555
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0145537
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.014522
LMCD1 LIM and cysteine-rich domains 1 0.0142855

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.217564
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.13486
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.129956
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.115378
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.110277
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.10537
NBEA neurobeachin -0.0961236
GOLGA4 golgin A4 -0.092483
TMSB4X thymosin beta 4, X-linked -0.0918118
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0887973
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0883031
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0850581
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0850293
FLNB filamin B, beta -0.0827775
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0800217
S100A6 S100 calcium binding protein A6 -0.0780143
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0759807
NF1 neurofibromin 1 -0.0726455
ZNF292 zinc finger protein 292 -0.0714439
RTN4 reticulon 4 -0.0708786
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0707899
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0692373
RBM39 RNA binding motif protein 39 -0.0664486
NFIA nuclear factor I/A -0.0664177
ZFAND3 zinc finger, AN1-type domain 3 -0.0653876
SSBP2 single-stranded DNA binding protein 2 -0.0651974
TXNRD1 thioredoxin reductase 1 -0.0643173
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0626968
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0621017
EVI5 ecotropic viral integration site 5 -0.0619109
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0594726
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0580871
ZCCHC7 zinc finger, CCHC domain containing 7 -0.057369
ADAM10 ADAM metallopeptidase domain 10 -0.057027
DLG1 discs, large homolog 1 (Drosophila) -0.0563658
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0552938
KDM3A lysine (K)-specific demethylase 3A -0.0552818
PNISR PNN-interacting serine/arginine-rich protein -0.0550191
ANK2 ankyrin 2, neuronal -0.0542146
NAMPT nicotinamide phosphoribosyltransferase -0.0523311
MSI2 musashi RNA-binding protein 2 -0.0509871
HDLBP high density lipoprotein binding protein -0.0504242
GARS1 glycyl-tRNA synthetase 1 -0.0499838
RHBDD1 rhomboid domain containing 1 -0.0497353
LDHA lactate dehydrogenase A -0.0482827
EML4 echinoderm microtubule associated protein like 4 -0.0477276
ZBTB20 zinc finger and BTB domain containing 20 -0.0471541
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0468495
EEF2 eukaryotic translation elongation factor 2 -0.0463149
EXOC6B exocyst complex component 6B -0.0459542
PYGB phosphorylase, glycogen; brain -0.0454659
TMEM65 transmembrane protein 65 -0.0439398
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0435396
SMYD3 SET and MYND domain containing 3 -0.0434415
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0434162
BRWD1 bromodomain and WD repeat domain containing 1 -0.0428972
GNAS GNAS complex locus -0.0426136
NUP58 nucleoporin 58 -0.0422958
MON2 MON2 homolog (S. cerevisiae) -0.0422924
NBAS neuroblastoma amplified sequence -0.0420034
WSB1 WD repeat and SOCS box containing 1 -0.0418939
USP3 ubiquitin specific peptidase 3 -0.0413482
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0412711
MATR3 matrin 3 -0.0411912
LPP LIM domain containing preferred translocation partner in lipoma -0.0408399
COG5 component of oligomeric golgi complex 5 -0.0407164
CAMKMT calmodulin-lysine N-methyltransferase -0.0403694
TCF12 transcription factor 12 -0.040163
GSK3B glycogen synthase kinase 3 beta -0.0399518
SBF2 SET binding factor 2 -0.0398224
PGK1 phosphoglycerate kinase 1 -0.039727
SREBF2 sterol regulatory element binding transcription factor 2 -0.0394882
NEBL nebulette -0.0394191
NPAS2 neuronal PAS domain protein 2 -0.0392802
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0390217
TMEM41B transmembrane protein 41B -0.0386105
PTBP2 polypyrimidine tract binding protein 2 -0.0380955
TTC3 tetratricopeptide repeat domain 3 -0.0380383
GPHN gephyrin -0.0376268
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0376154
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0371736
AHI1 Abelson helper integration site 1 -0.0365038
CANX calnexin -0.0364738
FKBP10 FK506 binding protein 10, 65 kDa -0.0362689
IGF1R insulin-like growth factor 1 receptor -0.0361854
FBXO11 F-box protein 11 -0.0358048
VCL vinculin -0.035763
QKI QKI, KH domain containing, RNA binding -0.0357442
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.035484
DENND1A DENN/MADD domain containing 1A -0.0354794
RAB6A RAB6A, member RAS oncogene family -0.0352659
NCOR1 nuclear receptor corepressor 1 -0.0351168
AHNAK AHNAK nucleoprotein -0.0351059
IARS1 isoleucyl-tRNA synthetase 1 -0.0350717
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.035067
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0348847
FNDC3B fibronectin type III domain containing 3B -0.0347512
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0347128
RPLP0 ribosomal protein, large, P0 -0.0346242
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0343841