| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.138575 |
| RPS3 | ribosomal protein S3 | 0.113732 |
| HDAC9 | histone deacetylase 9 | 0.110127 |
| RPS6 | ribosomal protein S6 | 0.103837 |
| RPS12 | ribosomal protein S12 | 0.0954917 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0809789 |
| TAPBP | TAP binding protein (tapasin) | 0.075975 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0694154 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0660263 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0590762 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0588206 |
| RPL37A | ribosomal protein L37a | 0.0572518 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0525051 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0512147 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0505093 |
| B2M | beta-2-microglobulin | 0.0501777 |
| BICC1 | BicC family RNA binding protein 1 | 0.049369 |
| LDHA | lactate dehydrogenase A | 0.0479021 |
| BRD2 | bromodomain containing 2 | 0.0466248 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0454366 |
| STC2 | stanniocalcin 2 | 0.0440018 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0430698 |
| RPS2 | ribosomal protein S2 | 0.042915 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0426316 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0426038 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0420751 |
| ARRDC3 | arrestin domain containing 3 | 0.0415164 |
| RPS8 | ribosomal protein S8 | 0.0409378 |
| VEGFA | vascular endothelial growth factor A | 0.0404915 |
| RUNX1 | runt-related transcription factor 1 | 0.040137 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.039933 |
| GOLGB1 | golgin B1 | 0.039542 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.039338 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.038379 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0362466 |
| GPC6 | glypican 6 | 0.0361932 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0361696 |
| ASPH | aspartate beta-hydroxylase | 0.0358289 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0336578 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0334778 |
| RPL36 | ribosomal protein L36 | 0.0322695 |
| RPL26 | ribosomal protein L26 | 0.0313097 |
| INTS6 | integrator complex subunit 6 | 0.0307433 |
| RPS19 | ribosomal protein S19 | 0.0299668 |
| RPS17 | ribosomal protein S17 | 0.029942 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0297443 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.029234 |
| RPL13A | ribosomal protein L13a | 0.0287189 |
| TLE4 | transducin-like enhancer of split 4 | 0.0286028 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0285286 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0284198 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.028289 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0278099 |
| SYNJ2 | synaptojanin 2 | 0.0273801 |
| RND3 | Rho family GTPase 3 | 0.0273778 |
| RACK1 | receptor for activated C kinase 1 | 0.0273584 |
| RPL11 | ribosomal protein L11 | 0.0272602 |
| RPL14 | ribosomal protein L14 | 0.0265745 |
| SFTPA2 | surfactant protein A2 | 0.026108 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0258034 |
| TRIM55 | tripartite motif containing 55 | 0.0252556 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0252359 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0250211 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.024932 |
| ATF3 | activating transcription factor 3 | 0.0241158 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0239899 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0238666 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0236477 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0233719 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0231609 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0229617 |
| RPL9 | ribosomal protein L9 | 0.022714 |
| RPL32 | ribosomal protein L32 | 0.0226377 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0224299 |
| TMF1 | TATA element modulatory factor 1 | 0.0224215 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0223409 |
| RPL7 | ribosomal protein L7 | 0.0222687 |
| KYNU | kynureninase | 0.0221614 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.021988 |
| RPL18 | ribosomal protein L18 | 0.0213623 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.021175 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0210277 |
| NDRG1 | N-myc downstream regulated 1 | 0.0208 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0207989 |
| RPL10A | ribosomal protein L10a | 0.0200986 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0200745 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0200722 |
| NGF | nerve growth factor (beta polypeptide) | 0.0199216 |
| RPS10 | ribosomal protein S10 | 0.0198744 |
| FAM107B | family with sequence similarity 107, member B | 0.0198282 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0193205 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0192271 |
| RPS29 | ribosomal protein S29 | 0.0192213 |
| DSTN | destrin (actin depolymerizing factor) | 0.0191429 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0189883 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0186986 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0185572 |
| SP100 | SP100 nuclear antigen | 0.0182455 |
| RPL37 | ribosomal protein L37 | 0.0181776 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0181437 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.280154 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.201551 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.144044 |
| FN1 | fibronectin 1 | -0.140039 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.12904 |
| FRMD4A | FERM domain containing 4A | -0.10614 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0967227 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0875806 |
| CD44 | CD44 molecule (Indian blood group) | -0.0865205 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0830235 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0814295 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.080818 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0774793 |
| UBC | ubiquitin C | -0.076738 |
| PGK1 | phosphoglycerate kinase 1 | -0.074725 |
| CADM1 | cell adhesion molecule 1 | -0.0745186 |
| TPM4 | tropomyosin 4 | -0.0736653 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0694218 |
| TMSB10 | thymosin beta 10 | -0.0687928 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.068208 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0680901 |
| RPS24 | ribosomal protein S24 | -0.0673583 |
| RTN4 | reticulon 4 | -0.0668064 |
| CTSD | cathepsin D | -0.0664496 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0613585 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0600711 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0571834 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0564459 |
| DIAPH2 | diaphanous-related formin 2 | -0.0536211 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0525324 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.052044 |
| PDE10A | phosphodiesterase 10A | -0.0513705 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0509916 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.050592 |
| CANX | calnexin | -0.050178 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0500408 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0499002 |
| GNAS | GNAS complex locus | -0.0497406 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0483296 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0478014 |
| ZNF292 | zinc finger protein 292 | -0.0475397 |
| IER3 | immediate early response 3 | -0.0462869 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0460294 |
| HLA-E | major histocompatibility complex, class I, E | -0.0452228 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0449545 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0436129 |
| OGA | O-GlcNAcase | -0.0430849 |
| CLIC4 | chloride intracellular channel 4 | -0.0429584 |
| ATP13A3 | ATPase type 13A3 | -0.0424493 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0423859 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0420164 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0418861 |
| DENND5A | DENN/MADD domain containing 5A | -0.0418455 |
| XIAP | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | -0.0412902 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0403081 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0401511 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0401488 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0401435 |
| TAOK1 | TAO kinase 1 | -0.0398153 |
| FBXO11 | F-box protein 11 | -0.039358 |
| SBF2 | SET binding factor 2 | -0.0390763 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0384866 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.0384145 |
| PTMA | prothymosin, alpha | -0.0382643 |
| ERBIN | erbb2 interacting protein | -0.0381023 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0380209 |
| FOXO3 | forkhead box O3 | -0.0372409 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0367178 |
| RPLP1 | ribosomal protein, large, P1 | -0.0366809 |
| NF1 | neurofibromin 1 | -0.0361152 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0357433 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0356836 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0351995 |
| TMEM123 | transmembrane protein 123 | -0.0347851 |
| PHF21A | PHD finger protein 21A | -0.0345711 |
| RPL36A | ribosomal protein L36a | -0.034566 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.034365 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0340637 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0340385 |
| AHNAK | AHNAK nucleoprotein | -0.0337497 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0337187 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0334762 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0334291 |
| TUBB | tubulin, beta class I | -0.0334038 |
| ARF4 | ADP-ribosylation factor 4 | -0.0332339 |
| RPL23 | ribosomal protein L23 | -0.0331652 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.033132 |
| WTAP | Wilms tumor 1 associated protein | -0.0327977 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.032674 |
| SPAG9 | sperm associated antigen 9 | -0.032644 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.032538 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0324018 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0323947 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0323761 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0323409 |
| MAP4 | microtubule-associated protein 4 | -0.0323241 |
| COL1A1 | collagen, type I, alpha 1 | -0.0320556 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0320404 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.031761 |
| KPNB1 | karyopherin (importin) beta 1 | -0.031675 |
