| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.176781 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.132263 |
| FN1 | fibronectin 1 | 0.117188 |
| HLA-B | major histocompatibility complex, class I, B | 0.112861 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.105763 |
| COL5A1 | collagen, type V, alpha 1 | 0.10481 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0970875 |
| B2M | beta-2-microglobulin | 0.0968783 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0779563 |
| PRELID2 | PRELI domain containing 2 | 0.0769588 |
| KYNU | kynureninase | 0.0734865 |
| ASPH | aspartate beta-hydroxylase | 0.0728427 |
| CD44 | CD44 molecule (Indian blood group) | 0.0689699 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0687589 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0641464 |
| GLIS3 | GLIS family zinc finger 3 | 0.0611043 |
| TAPBP | TAP binding protein (tapasin) | 0.0598783 |
| GOLGB1 | golgin B1 | 0.0585922 |
| MYOF | myoferlin | 0.0573381 |
| INTS6 | integrator complex subunit 6 | 0.0539007 |
| RPS6 | ribosomal protein S6 | 0.0527869 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0522049 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0518493 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0511242 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0510569 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0499516 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0499102 |
| RPL11 | ribosomal protein L11 | 0.0485679 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0473154 |
| HMGA2 | high mobility group AT-hook 2 | 0.0471264 |
| NAV1 | neuron navigator 1 | 0.04634 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0456983 |
| EGFR | epidermal growth factor receptor | 0.04526 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0449464 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0449324 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0444799 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0434575 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0427321 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0424055 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0421255 |
| RPS8 | ribosomal protein S8 | 0.0416619 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0415806 |
| EXOC4 | exocyst complex component 4 | 0.0415036 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0411893 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0403778 |
| LDHA | lactate dehydrogenase A | 0.0402173 |
| CALD1 | caldesmon 1 | 0.0394061 |
| RUNX1 | runt-related transcription factor 1 | 0.0390168 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0388025 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0375625 |
| AUTS2 | autism susceptibility candidate 2 | 0.0373302 |
| RPS3 | ribosomal protein S3 | 0.0367857 |
| SETBP1 | SET binding protein 1 | 0.0367796 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0352029 |
| LAMB1 | laminin, beta 1 | 0.0351956 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0351114 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0349816 |
| ATXN1 | ataxin 1 | 0.0346992 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0344948 |
| ITGAV | integrin, alpha V | 0.0344039 |
| FLNA | filamin A, alpha | 0.0343936 |
| SEPTIN11 | septin 11 | 0.0334813 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0332352 |
| DST | dystonin | 0.0330619 |
| HLA-A | major histocompatibility complex, class I, A | 0.0328364 |
| SON | SON DNA binding protein | 0.032422 |
| RPL37A | ribosomal protein L37a | 0.0321443 |
| TNS3 | tensin 3 | 0.0321301 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0319554 |
| IL6ST | interleukin 6 signal transducer | 0.031939 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0316114 |
| VCL | vinculin | 0.0314948 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0314781 |
| TLN1 | talin 1 | 0.0307894 |
| MEF2A | myocyte enhancer factor 2A | 0.030766 |
| FAM219A | family with sequence similarity 219, member A | 0.0306216 |
| RPS2 | ribosomal protein S2 | 0.0304409 |
| MSN | moesin | 0.0301022 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0299671 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0298055 |
| POTEF | POTE ankyrin domain family, member F | 0.029723 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0295473 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.029279 |
| TPM3 | tropomyosin 3 | 0.0291936 |
| LOXL2 | lysyl oxidase-like 2 | 0.0290511 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0290073 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0289178 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0288612 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0285606 |
| SEPTIN9 | septin 9 | 0.0285539 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0284048 |
| IL6 | interleukin 6 | 0.0283151 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0282542 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0281829 |
| RAD51B | RAD51 paralog B | 0.0276612 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0274907 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0273907 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0271961 |
| AHNAK | AHNAK nucleoprotein | 0.0268809 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0266613 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | -0.131257 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.102956 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.101753 |
| NDRG1 | N-myc downstream regulated 1 | -0.097996 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.089621 |
| FAM13A | family with sequence similarity 13, member A | -0.0848484 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0821263 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0796855 |
| GOLGA4 | golgin A4 | -0.0736346 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0735715 |
| COL1A2 | collagen, type I, alpha 2 | -0.0685164 |
| TMSB10 | thymosin beta 10 | -0.0651626 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0609462 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0570725 |
| ADM | adrenomedullin | -0.056392 |
| CADM1 | cell adhesion molecule 1 | -0.0554186 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.054366 |
| TMEM165 | transmembrane protein 165 | -0.0527965 |
| MT1X | metallothionein 1X | -0.0527904 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0524822 |
| ARRDC3 | arrestin domain containing 3 | -0.0521187 |
| RNF145 | ring finger protein 145 | -0.0519679 |
| ZNF292 | zinc finger protein 292 | -0.0515496 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0511463 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.050951 |
| H3-3B | H3.3 histone B | -0.0507998 |
| RLF | rearranged L-myc fusion | -0.0504752 |
| KAZN | kazrin, periplakin interacting protein | -0.0483929 |
| ARF4 | ADP-ribosylation factor 4 | -0.0475961 |
| ATP13A3 | ATPase type 13A3 | -0.0464968 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0458932 |
| CALU | calumenin | -0.0452881 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.044413 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.043895 |
| SRP54 | signal recognition particle 54kDa | -0.0436245 |
| LMAN1 | lectin, mannose-binding, 1 | -0.04253 |
| IKBIP | IKBKB interacting protein | -0.0421973 |
| COPA | coatomer protein complex, subunit alpha | -0.042073 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0419056 |
| ZNF207 | zinc finger protein 207 | -0.0409097 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0407859 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0406004 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0393547 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0388659 |
| NOP58 | NOP58 ribonucleoprotein | -0.0388497 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0387993 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0386913 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0385909 |
| SETD5 | SET domain containing 5 | -0.0379516 |
| CD99 | CD99 molecule | -0.0378778 |
| COG5 | component of oligomeric golgi complex 5 | -0.0370621 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0364782 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0362118 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0359106 |
| ANKRD17 | ankyrin repeat domain 17 | -0.035508 |
| MT2A | metallothionein 2A | -0.0348696 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0346614 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0345233 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0344743 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0343133 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0338656 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0336448 |
| RTN4 | reticulon 4 | -0.0332636 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0331319 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0330776 |
| LOX | lysyl oxidase | -0.0330439 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.03296 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0327078 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0324757 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0321664 |
| NUP54 | nucleoporin 54kDa | -0.0319947 |
| CLINT1 | clathrin interactor 1 | -0.0318736 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0317782 |
| TNPO3 | transportin 3 | -0.0313085 |
| INSIG2 | insulin induced gene 2 | -0.0311947 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0311504 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0311334 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0304973 |
| USP3 | ubiquitin specific peptidase 3 | -0.0300808 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0299756 |
| CD109 | CD109 molecule | -0.0296223 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0292759 |
| CTSD | cathepsin D | -0.0290272 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0289775 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0289577 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.028939 |
| COL1A1 | collagen, type I, alpha 1 | -0.0288468 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0286697 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0284673 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0284277 |
| HBP1 | HMG-box transcription factor 1 | -0.0283695 |
| MMP12 | matrix metallopeptidase 12 | -0.0282961 |
| GLG1 | golgi glycoprotein 1 | -0.0280343 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0279317 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0278997 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0278904 |
| KLHDC10 | kelch domain containing 10 | -0.0277923 |
| FTL | ferritin, light polypeptide | -0.0277332 |
| VIM | vimentin | -0.0273718 |
| CANX | calnexin | -0.0271987 |
