| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.134265 |
| RPS3 | ribosomal protein S3 | 0.0836274 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0796863 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0736008 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0714046 |
| SQSTM1 | sequestosome 1 | 0.068269 |
| B2M | beta-2-microglobulin | 0.0660614 |
| LDHA | lactate dehydrogenase A | 0.0641394 |
| GOLGA4 | golgin A4 | 0.0631012 |
| TPI1 | triosephosphate isomerase 1 | 0.0628724 |
| TXNRD1 | thioredoxin reductase 1 | 0.0580719 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0578632 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0576364 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0574919 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0563778 |
| RPS12 | ribosomal protein S12 | 0.0550039 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0546402 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0525452 |
| SMAD3 | SMAD family member 3 | 0.0515748 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0505406 |
| RPL26 | ribosomal protein L26 | 0.049016 |
| INTS6 | integrator complex subunit 6 | 0.0483437 |
| AHNAK | AHNAK nucleoprotein | 0.0472864 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0472193 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0466818 |
| ENO1 | enolase 1, (alpha) | 0.0442571 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0441083 |
| BRD2 | bromodomain containing 2 | 0.0438386 |
| UBB | ubiquitin B | 0.0414056 |
| ACTG1 | actin gamma 1 | 0.0412261 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0404414 |
| RPS6 | ribosomal protein S6 | 0.0383311 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.037702 |
| TAPBP | TAP binding protein (tapasin) | 0.0372375 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0369172 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0362889 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0361878 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0359637 |
| FTL | ferritin, light polypeptide | 0.0355754 |
| PTMA | prothymosin, alpha | 0.0351973 |
| DST | dystonin | 0.0348686 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0347353 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0344747 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.033674 |
| GOLGB1 | golgin B1 | 0.0336336 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0331603 |
| CAVIN1 | caveolae associated protein 1 | 0.0329746 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0323534 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0318418 |
| TBCA | tubulin folding cofactor A | 0.0313259 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0312116 |
| RACK1 | receptor for activated C kinase 1 | 0.0307415 |
| TMF1 | TATA element modulatory factor 1 | 0.0300907 |
| POTEF | POTE ankyrin domain family, member F | 0.0300678 |
| COMMD10 | COMM domain containing 10 | 0.0298715 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0296489 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0294666 |
| UTRN | utrophin | 0.0291198 |
| RPL36 | ribosomal protein L36 | 0.0290478 |
| MYOF | myoferlin | 0.028818 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0286489 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.02854 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.028277 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0280899 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0279096 |
| DSTN | destrin (actin depolymerizing factor) | 0.0276598 |
| TPR | translocated promoter region, nuclear basket protein | 0.0276433 |
| RPS17 | ribosomal protein S17 | 0.0273876 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0272794 |
| CWC15 | CWC15 spliceosome-associated protein | 0.0271151 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0268954 |
| RPS29 | ribosomal protein S29 | 0.0267846 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.026471 |
| ATXN1 | ataxin 1 | 0.0262478 |
| RPL37A | ribosomal protein L37a | 0.0261655 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0260417 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0260249 |
| TLE4 | transducin-like enhancer of split 4 | 0.0259868 |
| ANXA1 | annexin A1 | 0.0257456 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0256943 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0256002 |
| RBM39 | RNA binding motif protein 39 | 0.0254634 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0253971 |
| JMJD1C | jumonji domain containing 1C | 0.0251569 |
| RPL32 | ribosomal protein L32 | 0.0249072 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0248751 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0248436 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0246851 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0246738 |
| RPL34 | ribosomal protein L34 | 0.0244723 |
| RPL18 | ribosomal protein L18 | 0.0242181 |
| RPS23 | ribosomal protein S23 | 0.0240784 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.023913 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0238187 |
| CDC37 | cell division cycle 37 | 0.0236078 |
| SET | SET nuclear proto-oncogene | 0.0235181 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0234688 |
| CANX | calnexin | 0.0234295 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0233371 |
| RPS13 | ribosomal protein S13 | 0.0230193 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0697111 |
| VIM | vimentin | -0.0657739 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0634127 |
| SPAG9 | sperm associated antigen 9 | -0.0520336 |
| SMYD3 | SET and MYND domain containing 3 | -0.0515467 |
| DNER | delta/notch-like EGF repeat containing | -0.0501622 |
| ZNF292 | zinc finger protein 292 | -0.0468598 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0446055 |
| PYGL | phosphorylase, glycogen, liver | -0.0359694 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0349162 |
| IGF2 | insulin-like growth factor 2 | -0.0336946 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0333097 |
| KIAA1328 | KIAA1328 | -0.0325476 |
| PTK2 | protein tyrosine kinase 2 | -0.0317402 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0314133 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0309863 |
| ZNF609 | zinc finger protein 609 | -0.0301127 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0297549 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0290697 |
| YAP1 | Yes-associated protein 1 | -0.0284505 |
| TMSB10 | thymosin beta 10 | -0.0283189 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0280062 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0271437 |
| NF1 | neurofibromin 1 | -0.0270017 |
| UBAC2 | UBA domain containing 2 | -0.0268047 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0265264 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.026522 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0264229 |
| ATG7 | autophagy related 7 | -0.0263618 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0262966 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0262012 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0261976 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0256986 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0255894 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0251558 |
| RAD51B | RAD51 paralog B | -0.0250086 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0247559 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0246045 |
| ATXN2 | ataxin 2 | -0.0244497 |
| EGR1 | early growth response 1 | -0.0242908 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.024178 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.024056 |
| RPLP1 | ribosomal protein, large, P1 | -0.0238897 |
| NUP98 | nucleoporin 98kDa | -0.0235748 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0235525 |
| FAM13B | family with sequence similarity 13, member B | -0.0228473 |
| NALCN | sodium leak channel, non selective | -0.0227696 |
| MT2A | metallothionein 2A | -0.0226005 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0223202 |
| PCED1B | PC-esterase domain containing 1B | -0.0221307 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0218053 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0217113 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0215188 |
| MCL1 | myeloid cell leukemia 1 | -0.0211461 |
| CWF19L2 | CWF19-like 2, cell cycle control (S. pombe) | -0.0209227 |
| FAM3C | family with sequence similarity 3, member C | -0.0207736 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0206865 |
| USP34 | ubiquitin specific peptidase 34 | -0.0205344 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.020433 |
| GOLT1B | golgi transport 1B | -0.0201332 |
| ACER3 | alkaline ceramidase 3 | -0.0200738 |
| NBAS | neuroblastoma amplified sequence | -0.0196916 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.019626 |
| MECP2 | methyl CpG binding protein 2 | -0.0196218 |
| GAPVD1 | GTPase activating protein and VPS9 domains 1 | -0.0196141 |
| STXBP1 | syntaxin binding protein 1 | -0.0193506 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.019285 |
| MYO9B | myosin IXB | -0.0190837 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0188758 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0188333 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0184986 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0184869 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0183129 |
| PHF20 | PHD finger protein 20 | -0.0182555 |
| GLG1 | golgi glycoprotein 1 | -0.0181047 |
| TUBB | tubulin, beta class I | -0.0180064 |
| HM13 | histocompatibility (minor) 13 | -0.0179886 |
| FAM193A | family with sequence similarity 193, member A | -0.0177676 |
| CALU | calumenin | -0.0177574 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0177275 |
| MED13L | mediator complex subunit 13-like | -0.0175432 |
| GPC6 | glypican 6 | -0.0175364 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.017349 |
| RBM6 | RNA binding motif protein 6 | -0.017267 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0172549 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0172514 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0172473 |
| XRN2 | 5'-3' exoribonuclease 2 | -0.0171783 |
| TAOK3 | TAO kinase 3 | -0.0171623 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0171058 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0170047 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0169276 |
| PPHLN1 | periphilin 1 | -0.0168625 |
| FN1 | fibronectin 1 | -0.0168386 |
| TNPO3 | transportin 3 | -0.0166807 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0166798 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0165703 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0165696 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.0165598 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0165583 |
