| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.132711 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.120627 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.112856 |
| STC2 | stanniocalcin 2 | 0.102482 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0964971 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0937296 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0920831 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.084985 |
| MT2A | metallothionein 2A | 0.0792966 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0743314 |
| RPS6 | ribosomal protein S6 | 0.0709229 |
| RUNX1 | runt-related transcription factor 1 | 0.0674387 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0648335 |
| CD109 | CD109 molecule | 0.0630258 |
| NDRG1 | N-myc downstream regulated 1 | 0.0618513 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0613195 |
| RAI14 | retinoic acid induced 14 | 0.0613094 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0606888 |
| RPS12 | ribosomal protein S12 | 0.0569546 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0565686 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0564027 |
| B2M | beta-2-microglobulin | 0.0562344 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0561001 |
| SFTPA2 | surfactant protein A2 | 0.0551852 |
| GOLGB1 | golgin B1 | 0.0548166 |
| MYOF | myoferlin | 0.0547269 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0542212 |
| GPATCH2L | G patch domain containing 2-like | 0.053556 |
| DSTN | destrin (actin depolymerizing factor) | 0.0532831 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.052585 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0524737 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0511199 |
| VEGFA | vascular endothelial growth factor A | 0.0508232 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0507758 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.049916 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.049558 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0493096 |
| LMNA | lamin A/C | 0.0453561 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0452083 |
| RPL37A | ribosomal protein L37a | 0.0450253 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.043221 |
| RPS3 | ribosomal protein S3 | 0.0430083 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0424751 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0424424 |
| SEPTIN9 | septin 9 | 0.0413404 |
| EZR | ezrin | 0.0407914 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0407153 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0404066 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0402458 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0401292 |
| TXNIP | thioredoxin interacting protein | 0.0397779 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0397278 |
| RACK1 | receptor for activated C kinase 1 | 0.0394244 |
| GOLGA4 | golgin A4 | 0.0393285 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0391834 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0388628 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0388471 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.038847 |
| RPL18 | ribosomal protein L18 | 0.0388299 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0382573 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0381042 |
| TAPBP | TAP binding protein (tapasin) | 0.0380259 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0376617 |
| RPS8 | ribosomal protein S8 | 0.0373941 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0369219 |
| PLIN2 | perilipin 2 | 0.0367888 |
| TMEM156 | transmembrane protein 156 | 0.0367086 |
| RBPMS | RNA binding protein with multiple splicing | 0.036497 |
| PCM1 | pericentriolar material 1 | 0.0362084 |
| TPM3 | tropomyosin 3 | 0.0360507 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0358737 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0356218 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0355884 |
| UBXN4 | UBX domain protein 4 | 0.0352743 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0345591 |
| FAT1 | FAT atypical cadherin 1 | 0.0343464 |
| LMO7 | LIM domain 7 | 0.0342333 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0342009 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0341414 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.034025 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0339892 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0338023 |
| PALLD | palladin, cytoskeletal associated protein | 0.0331665 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0326011 |
| LDHA | lactate dehydrogenase A | 0.032409 |
| MB21D2 | Mab-21 domain containing 2 | 0.031981 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0319433 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0319278 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0318892 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0317152 |
| SYNJ2 | synaptojanin 2 | 0.0316583 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0316389 |
| WBP11 | WW domain binding protein 11 | 0.0312827 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0311217 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0309988 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0308794 |
| NXN | nucleoredoxin | 0.0308692 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0307723 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.030621 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0301245 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.179795 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152218 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.147674 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.131057 |
| CANX | calnexin | -0.11127 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.105893 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0982503 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0803567 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0720008 |
| NRG1 | neuregulin 1 | -0.0686158 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0542364 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0527304 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.052071 |
| RPS24 | ribosomal protein S24 | -0.0507088 |
| AHR | aryl hydrocarbon receptor | -0.0499251 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0486121 |
| UBC | ubiquitin C | -0.0475696 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0442345 |
| S100A6 | S100 calcium binding protein A6 | -0.0435496 |
| OSMR | oncostatin M receptor | -0.0424039 |
| NEK7 | NIMA-related kinase 7 | -0.0411918 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0411058 |
| COG5 | component of oligomeric golgi complex 5 | -0.0400905 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0390971 |
| SMOX | spermine oxidase | -0.0379877 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0377394 |
| OGA | O-GlcNAcase | -0.036409 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0363837 |
| SPAG9 | sperm associated antigen 9 | -0.0363463 |
| RPLP1 | ribosomal protein, large, P1 | -0.0362521 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0359337 |
| SUCO | SUN domain containing ossification factor | -0.0356843 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0349466 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0345661 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0345035 |
| RPS27A | ribosomal protein S27a | -0.0342124 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0339148 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0335555 |
| TFG | TRK-fused gene | -0.0327824 |
| ARF1 | ADP-ribosylation factor 1 | -0.032429 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0322658 |
| DENND5B | DENN/MADD domain containing 5B | -0.0319054 |
| ZNF292 | zinc finger protein 292 | -0.0314996 |
| FAM20C | family with sequence similarity 20, member C | -0.0313786 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0312335 |
| HLA-B | major histocompatibility complex, class I, B | -0.0309633 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0308249 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | -0.0308196 |
| CALU | calumenin | -0.0307898 |
| TMEM165 | transmembrane protein 165 | -0.0300112 |
| SQSTM1 | sequestosome 1 | -0.0296635 |
| ETNK1 | ethanolamine kinase 1 | -0.0293176 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0290117 |
| ETV6 | ets variant 6 | -0.0288992 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0288132 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0286608 |
| RHEB | Ras homolog enriched in brain | -0.028639 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0283666 |
| COPA | coatomer protein complex, subunit alpha | -0.0280797 |
| VCL | vinculin | -0.0280209 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0276723 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0276315 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0273698 |
| CTSD | cathepsin D | -0.0272717 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0269402 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0268395 |
| IER3 | immediate early response 3 | -0.0266789 |
| LOX | lysyl oxidase | -0.0265929 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0263773 |
| GLIS3 | GLIS family zinc finger 3 | -0.0260019 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0258376 |
| AEBP2 | AE binding protein 2 | -0.0251896 |
| ZNF207 | zinc finger protein 207 | -0.0248638 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0247104 |
| GNAS | GNAS complex locus | -0.024352 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0243061 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0242543 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0242072 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0239226 |
| CLINT1 | clathrin interactor 1 | -0.0237454 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0237429 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | -0.0237279 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0237179 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0237014 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0236753 |
| RPL23 | ribosomal protein L23 | -0.0236413 |
| RPS20 | ribosomal protein S20 | -0.0235509 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0234688 |
| RPS16 | ribosomal protein S16 | -0.02324 |
| PELO | pelota homolog (Drosophila) | -0.0231724 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0231529 |
| FOXO3 | forkhead box O3 | -0.0229994 |
| FBXO34 | F-box protein 34 | -0.0228407 |
| WDR26 | WD repeat domain 26 | -0.022728 |
| FBXO28 | F-box protein 28 | -0.0226511 |
| USP34 | ubiquitin specific peptidase 34 | -0.0225751 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0225735 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0225042 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0222956 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0222029 |
