| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | 0.117516 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.109922 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.101912 |
| RPS3 | ribosomal protein S3 | 0.0986283 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0899161 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0848995 |
| GOLGA4 | golgin A4 | 0.0826732 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0801443 |
| GOLGB1 | golgin B1 | 0.0759286 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0753077 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0749928 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0729236 |
| RPS12 | ribosomal protein S12 | 0.0726268 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0680935 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0637652 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.056027 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0554482 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0538096 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0535065 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0534852 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0533816 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0525075 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0503349 |
| BRD2 | bromodomain containing 2 | 0.0489378 |
| TMF1 | TATA element modulatory factor 1 | 0.0483935 |
| RPL32 | ribosomal protein L32 | 0.0483508 |
| FAM107B | family with sequence similarity 107, member B | 0.0479841 |
| SET | SET nuclear proto-oncogene | 0.0474343 |
| RPL37A | ribosomal protein L37a | 0.0450021 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0449794 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0447159 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0445411 |
| RPS2 | ribosomal protein S2 | 0.0441449 |
| NEBL | nebulette | 0.0439905 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0426577 |
| SMAD3 | SMAD family member 3 | 0.0425586 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0422968 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0419204 |
| CENPF | centromere protein F, 350/400kDa | 0.0405919 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0403701 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0400833 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0400274 |
| RPL13A | ribosomal protein L13a | 0.0398904 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.039447 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0394312 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.039337 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0391451 |
| DOCK4 | dedicator of cytokinesis 4 | 0.03889 |
| DSPP | dentin sialophosphoprotein | 0.0388774 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0378472 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0377187 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0366276 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0361569 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0360774 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0358911 |
| RND3 | Rho family GTPase 3 | 0.0354274 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0345683 |
| PNN | pinin, desmosome associated protein | 0.0345541 |
| RPL18 | ribosomal protein L18 | 0.034492 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0337604 |
| MALT1 | MALT1 paracaspase | 0.0336661 |
| RPS19 | ribosomal protein S19 | 0.033665 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0336047 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0336016 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0329523 |
| INTS6 | integrator complex subunit 6 | 0.032674 |
| RPL14 | ribosomal protein L14 | 0.032375 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0318539 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0317064 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0314333 |
| TRIM2 | tripartite motif containing 2 | 0.0312865 |
| SON | SON DNA binding protein | 0.0310546 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0307965 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0305354 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0302221 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0300416 |
| RPS8 | ribosomal protein S8 | 0.0297533 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0296104 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.029485 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0290458 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0289922 |
| RBM39 | RNA binding motif protein 39 | 0.0287404 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0283914 |
| WWC1 | WW and C2 domain containing 1 | 0.0283601 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0281173 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0280803 |
| CUL3 | cullin 3 | 0.0275703 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0275664 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0274664 |
| MKI67 | marker of proliferation Ki-67 | 0.0273078 |
| RPL5 | ribosomal protein L5 | 0.0267411 |
| RPS17 | ribosomal protein S17 | 0.0267163 |
| WASL | Wiskott-Aldrich syndrome-like | 0.0266411 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0265884 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0265452 |
| PAPOLA | poly(A) polymerase alpha | 0.0262278 |
| RPL19 | ribosomal protein L19 | 0.0262191 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0259285 |
| SMAD2 | SMAD family member 2 | 0.0258479 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0257853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.166263 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.111877 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.100424 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0869007 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0812012 |
| KRT18 | keratin 18, type I | -0.0773854 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.075945 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0706263 |
| BCL2L1 | BCL2-like 1 | -0.0682103 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0677689 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0675931 |
| PERP | PERP, TP53 apoptosis effector | -0.0521901 |
| KRT8 | keratin 8, type II | -0.0500718 |
| RPS24 | ribosomal protein S24 | -0.0499071 |
| TMSB10 | thymosin beta 10 | -0.0497436 |
| RPLP1 | ribosomal protein, large, P1 | -0.0493646 |
| S100A6 | S100 calcium binding protein A6 | -0.0467078 |
| CTSD | cathepsin D | -0.0447574 |
| TMEM123 | transmembrane protein 123 | -0.0440414 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0421776 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0417547 |
| PTMA | prothymosin, alpha | -0.0415014 |
| RPS25 | ribosomal protein S25 | -0.0414801 |
| IER3 | immediate early response 3 | -0.0399777 |
| PLAUR | plasminogen activator, urokinase receptor | -0.038884 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0386262 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0384607 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0376561 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0375623 |
| NDRG1 | N-myc downstream regulated 1 | -0.0367143 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.036152 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0349876 |
| EGR1 | early growth response 1 | -0.034899 |
| HMGA1 | high mobility group AT-hook 1 | -0.033895 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0337866 |
| RPL27A | ribosomal protein L27a | -0.0329231 |
| HLA-A | major histocompatibility complex, class I, A | -0.0320577 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0319178 |
| UBC | ubiquitin C | -0.0317015 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0313007 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0305913 |
| XPO1 | exportin 1 | -0.0301888 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.029958 |
| PGK1 | phosphoglycerate kinase 1 | -0.029615 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0296002 |
| RPL36A | ribosomal protein L36a | -0.0294841 |
| CD2AP | CD2-associated protein | -0.0292875 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0287558 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0284823 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0276362 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0274328 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0273651 |
| MX2 | MX dynamin-like GTPase 2 | -0.0272957 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0272308 |
| TUBB | tubulin, beta class I | -0.0271159 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0270841 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0267055 |
| EPCAM | epithelial cell adhesion molecule | -0.0261626 |
| USP3 | ubiquitin specific peptidase 3 | -0.0260206 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0259823 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0254275 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0253576 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0250131 |
| EDN1 | endothelin 1 | -0.0249738 |
| ITGB4 | integrin, beta 4 | -0.0245743 |
| FRMD5 | FERM domain containing 5 | -0.0244507 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0244069 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0240469 |
| CADPS | Ca++-dependent secretion activator | -0.0239992 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0238805 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0236862 |
| S100A9 | S100 calcium binding protein A9 | -0.0236785 |
| EZR | ezrin | -0.0233451 |
| FNBP4 | formin binding protein 4 | -0.0225573 |
| CALU | calumenin | -0.022223 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0216917 |
| RBP1 | retinol binding protein 1, cellular | -0.0215932 |
| RPS5 | ribosomal protein S5 | -0.0214723 |
| KLK10 | kallikrein-related peptidase 10 | -0.0214466 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.021392 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0213534 |
| PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | -0.0213129 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0211506 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0211407 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0210374 |
| RPLP0 | ribosomal protein, large, P0 | -0.0210196 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0208864 |
| DIAPH2 | diaphanous-related formin 2 | -0.0205135 |
| SPNS2 | spinster homolog 2 (Drosophila) | -0.0204931 |
| RTN4 | reticulon 4 | -0.0204517 |
| CLDN4 | claudin 4 | -0.0203287 |
| RHEB | Ras homolog enriched in brain | -0.0202704 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0202048 |
| ACTN4 | actinin, alpha 4 | -0.0201823 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0200794 |
| MSI2 | musashi RNA-binding protein 2 | -0.0200792 |
| S100A10 | S100 calcium binding protein A10 | -0.0199145 |
| KRT19 | keratin 19, type I | -0.0198209 |
| RNF149 | ring finger protein 149 | -0.019695 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0194994 |
