AZD-7648_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.120986
EGFR epidermal growth factor receptor 0.109382
HSPA8 heat shock 70kDa protein 8 0.107216
ACTG1 actin gamma 1 0.106465
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0958077
ATXN1 ataxin 1 0.086081
HMGA2 high mobility group AT-hook 2 0.0756377
RPS6 ribosomal protein S6 0.0741682
RPS3 ribosomal protein S3 0.0702112
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0686073
EGR1 early growth response 1 0.0677729
LAMA4 laminin, alpha 4 0.0612701
SEPTIN9 septin 9 0.0592772
RPS8 ribosomal protein S8 0.0567384
SGMS2 sphingomyelin synthase 2 0.0559059
RPS12 ribosomal protein S12 0.0540978
SMAD3 SMAD family member 3 0.0501003
RCOR1 REST corepressor 1 0.0485361
NCEH1 neutral cholesterol ester hydrolase 1 0.0481582
LOC102724023 ES1 protein homolog, mitochondrial 0.0472265
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0442386
ZSWIM6 zinc finger, SWIM-type containing 6 0.0434855
CLIP2 CAP-GLY domain containing linker protein 2 0.0432863
ABR active BCR-related 0.0429123
AHNAK AHNAK nucleoprotein 0.042786
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0423055
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0408067
APLP2 amyloid beta (A4) precursor-like protein 2 0.0405746
ZFP36L1 ZFP36 ring finger protein-like 1 0.0398939
EXT1 exostosin glycosyltransferase 1 0.0384427
CTSB cathepsin B 0.0376679
RPS17 ribosomal protein S17 0.0366942
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0357144
SRRM2 serine/arginine repetitive matrix 2 0.0356268
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0342028
RPL26 ribosomal protein L26 0.0340023
EFNB2 ephrin-B2 0.0339169
RPS2 ribosomal protein S2 0.0335686
NUP50 nucleoporin 50kDa 0.0333372
MYH9 myosin, heavy chain 9, non-muscle 0.0332046
POTEF POTE ankyrin domain family, member F 0.0324601
SYNE2 spectrin repeat containing, nuclear envelope 2 0.032043
ASPH aspartate beta-hydroxylase 0.0319138
ZHX2 zinc fingers and homeoboxes 2 0.0318213
MACF1 microtubule-actin crosslinking factor 1 0.031516
HOMER1 homer scaffolding protein 1 0.0311583
NTSR1 neurotensin receptor 1 (high affinity) 0.0302833
RPS29 ribosomal protein S29 0.0298977
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0298825
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0297071
CPOX coproporphyrinogen oxidase 0.0295371
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0295302
CREB5 cAMP responsive element binding protein 5 0.0292179
DUSP4 dual specificity phosphatase 4 0.0291449
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0287512
RPL36 ribosomal protein L36 0.0275392
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0275038
FHL2 four and a half LIM domains 2 0.0267983
BRD2 bromodomain containing 2 0.0267812
DOCK5 dedicator of cytokinesis 5 0.0262647
CMIP c-Maf inducing protein 0.0262569
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0258645
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.0249754
RPL37A ribosomal protein L37a 0.0244326
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0243005
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0242914
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0242828
SNX9 sorting nexin 9 0.0242827
DSCAM Down syndrome cell adhesion molecule 0.0242667
FAT1 FAT atypical cadherin 1 0.0241481
RPL4 ribosomal protein L4 0.0241043
ALCAM activated leukocyte cell adhesion molecule 0.0239664
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0236159
RRM2 ribonucleotide reductase M2 0.0234648
KLF6 Kruppel-like factor 6 0.0234087
IGSF9B immunoglobulin superfamily, member 9B 0.0227938
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0224442
RACK1 receptor for activated C kinase 1 0.0222881
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0219121
GATAD2A GATA zinc finger domain containing 2A 0.0218728
KTN1 kinectin 1 (kinesin receptor) 0.0217275
TAPBP TAP binding protein (tapasin) 0.0217004
DOCK1 dedicator of cytokinesis 1 0.0210194
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.021003
BIRC3 baculoviral IAP repeat containing 3 0.0208378
SOX9 SRY (sex determining region Y)-box 9 0.0207602
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0202813
SFTPA2 surfactant protein A2 0.0200393
H1-2 H1.2 linker histone, cluster member 0.0199963
HDAC4 histone deacetylase 4 0.0199345
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.019734
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0196325
IER2 immediate early response 2 0.019627
EMP1 epithelial membrane protein 1 0.019396
LAMC2 laminin, gamma 2 0.0193734
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0193495
KSR2 kinase suppressor of ras 2 0.0192051
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0192043
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0191944
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0191613

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.268862
CD36 CD36 molecule (thrombospondin receptor) -0.250559
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.142635
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.11615
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.102158
FERMT1 fermitin family member 1 -0.099306
OXR1 oxidation resistance 1 -0.0905048
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0789692
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0771118
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0725338
SERINC5 serine incorporator 5 -0.0720962
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.071975
HDAC2 histone deacetylase 2 -0.0669062
RUNX2 runt-related transcription factor 2 -0.0612392
COG5 component of oligomeric golgi complex 5 -0.0608074
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0600895
ANXA1 annexin A1 -0.0598523
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0592292
NEK7 NIMA-related kinase 7 -0.0591101
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0581125
GARS1 glycyl-tRNA synthetase 1 -0.0564515
PTMA prothymosin, alpha -0.0539298
OSBPL3 oxysterol binding protein-like 3 -0.0535863
TXNRD1 thioredoxin reductase 1 -0.0530488
RPS24 ribosomal protein S24 -0.0525357
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0524919
USP3 ubiquitin specific peptidase 3 -0.0489635
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0482317
TOP1 topoisomerase (DNA) I -0.0468317
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0464263
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.045155
HILPDA hypoxia inducible lipid droplet-associated -0.0442204
RNF145 ring finger protein 145 -0.043844
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0424062
WAC WW domain containing adaptor with coiled-coil -0.0421173
LMO7 LIM domain 7 -0.0414364
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0405601
ZNF292 zinc finger protein 292 -0.0405563
PERP PERP, TP53 apoptosis effector -0.0403372
STRN3 striatin, calmodulin binding protein 3 -0.0396998
PUM2 pumilio RNA-binding family member 2 -0.0394536
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0387396
GDF15 growth differentiation factor 15 -0.0384691
RNF43 ring finger protein 43 -0.038141
AOPEP aminopeptidase O (putative) -0.038054
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0379073
NEMF nuclear export mediator factor -0.0378748
ZMYM2 zinc finger, MYM-type 2 -0.0378591
GOLGA4 golgin A4 -0.0376025
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0374151
KLF3 Kruppel-like factor 3 (basic) -0.0366662
ITPRID2 ITPR interacting domain containing 2 -0.0366596
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0359839
PTBP2 polypyrimidine tract binding protein 2 -0.0359383
BRWD1 bromodomain and WD repeat domain containing 1 -0.0358306
RBM25 RNA binding motif protein 25 -0.0356634
PDLIM5 PDZ and LIM domain 5 -0.0354871
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0352631
EEF2 eukaryotic translation elongation factor 2 -0.0350513
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0347088
RFX7 regulatory factor X, 7 -0.0346802
PARD3 par-3 family cell polarity regulator -0.0344149
FAM3C family with sequence similarity 3, member C -0.0337283
KDM6A lysine (K)-specific demethylase 6A -0.0336726
BIRC6 baculoviral IAP repeat containing 6 -0.0325783
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0323257
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0321333
ESYT2 extended synaptotagmin-like protein 2 -0.0319078
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0317805
SLMAP sarcolemma associated protein -0.031772
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0315303
TMSB10 thymosin beta 10 -0.0312338
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.030994
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0308894
ANKRD28 ankyrin repeat domain 28 -0.0305223
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0299942
RREB1 ras responsive element binding protein 1 -0.0296786
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0296189
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0293838
GPHN gephyrin -0.029352
LMAN1 lectin, mannose-binding, 1 -0.0292951
NFIA nuclear factor I/A -0.0292675
EREG epiregulin -0.0290745
RAD51B RAD51 paralog B -0.0287722
ANAPC5 anaphase promoting complex subunit 5 -0.0286877
PNISR PNN-interacting serine/arginine-rich protein -0.0286505
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.028435
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0282387
MARCHF6 membrane associated ring-CH-type finger 6 -0.0280131
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0279586
RAB6A RAB6A, member RAS oncogene family -0.0278944
TXNIP thioredoxin interacting protein -0.027847
RBM39 RNA binding motif protein 39 -0.0278078
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0277565
SBF2 SET binding factor 2 -0.0274942
NUP58 nucleoporin 58 -0.02732
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0272237
NPEPPS aminopeptidase puromycin sensitive -0.0271629
PKM pyruvate kinase, muscle -0.0270971
HMGA1 high mobility group AT-hook 1 -0.0267691