| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-7648 perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-7648_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.314656 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.16748 |
| RPS6 | ribosomal protein S6 | 0.145994 |
| RPS3 | ribosomal protein S3 | 0.138108 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.127131 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.118658 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.110369 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0924763 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.090746 |
| RPS12 | ribosomal protein S12 | 0.0888403 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0873932 |
| DSPP | dentin sialophosphoprotein | 0.0854045 |
| TNS3 | tensin 3 | 0.0795931 |
| RPL26 | ribosomal protein L26 | 0.0785766 |
| SYT1 | synaptotagmin I | 0.0776227 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0744804 |
| PTMA | prothymosin, alpha | 0.0730983 |
| LMO7 | LIM domain 7 | 0.0672167 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0635503 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0601654 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0598528 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0590915 |
| CDK6 | cyclin-dependent kinase 6 | 0.0589707 |
| EZR | ezrin | 0.0585 |
| RPS8 | ribosomal protein S8 | 0.0582081 |
| ENO1 | enolase 1, (alpha) | 0.055353 |
| CENPF | centromere protein F, 350/400kDa | 0.0553427 |
| WWOX | WW domain containing oxidoreductase | 0.0536126 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.053254 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0520648 |
| SET | SET nuclear proto-oncogene | 0.0481217 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0477421 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0471754 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0458142 |
| LDHA | lactate dehydrogenase A | 0.0452402 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0451591 |
| SPATA13 | spermatogenesis associated 13 | 0.0449479 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0442279 |
| YBX1 | Y box binding protein 1 | 0.0435534 |
| RPS2 | ribosomal protein S2 | 0.043197 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0428453 |
| DST | dystonin | 0.0423398 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0422214 |
| RACK1 | receptor for activated C kinase 1 | 0.0409102 |
| RPL36 | ribosomal protein L36 | 0.0407995 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0406474 |
| MKI67 | marker of proliferation Ki-67 | 0.0404022 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0402111 |
| RPL18 | ribosomal protein L18 | 0.0394379 |
| RPL19 | ribosomal protein L19 | 0.0393432 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0392454 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0373323 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.036793 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.03661 |
| CBX3 | chromobox homolog 3 | 0.0366062 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0360728 |
| RPS4X | ribosomal protein S4, X-linked | 0.0357824 |
| RPL7 | ribosomal protein L7 | 0.0351046 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.034842 |
| RPL37A | ribosomal protein L37a | 0.0344236 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0343629 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0343005 |
| BMP5 | bone morphogenetic protein 5 | 0.0342833 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0342561 |
| RPL37 | ribosomal protein L37 | 0.0341135 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0335458 |
| RPL32 | ribosomal protein L32 | 0.0332259 |
| PCM1 | pericentriolar material 1 | 0.0330333 |
| PNN | pinin, desmosome associated protein | 0.0329421 |
| AXIN2 | axin 2 | 0.0328678 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0327753 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0326996 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0319883 |
| TMEM123 | transmembrane protein 123 | 0.031932 |
| TPI1 | triosephosphate isomerase 1 | 0.0319012 |
| PCDH9 | protocadherin 9 | 0.0317018 |
| RPL5 | ribosomal protein L5 | 0.0316944 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.031432 |
| PCBP2 | poly(rC) binding protein 2 | 0.0313766 |
| SON | SON DNA binding protein | 0.0308878 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0308844 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0305235 |
| STK38L | serine/threonine kinase 38 like | 0.0299142 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.029755 |
| RPL14 | ribosomal protein L14 | 0.0295759 |
| GOLGB1 | golgin B1 | 0.0291824 |
| RUNX1 | runt-related transcription factor 1 | 0.0290403 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0290109 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0290078 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0287956 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0285784 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0282799 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0281918 |
| TPM3 | tropomyosin 3 | 0.02815 |
| YAP1 | Yes-associated protein 1 | 0.0279599 |
| KIZ | kizuna centrosomal protein | 0.0279151 |
| VCL | vinculin | 0.0275614 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0275589 |
| SERINC5 | serine incorporator 5 | 0.0275166 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0274809 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.0894594 |
| NAV2 | neuron navigator 2 | -0.0719716 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0642269 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0543208 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0474515 |
| HMGA1 | high mobility group AT-hook 1 | -0.0450879 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0437091 |
| RPLP1 | ribosomal protein, large, P1 | -0.0401566 |
| FTL | ferritin, light polypeptide | -0.0398504 |
| RPS24 | ribosomal protein S24 | -0.0391556 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0352922 |
| TMSB10 | thymosin beta 10 | -0.0350649 |
| KRT18 | keratin 18, type I | -0.0345391 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0336677 |
| CCND1 | cyclin D1 | -0.0330375 |
| RBP1 | retinol binding protein 1, cellular | -0.0325613 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.030662 |
| ANXA2 | annexin A2 | -0.0298347 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0292367 |
| ITGB4 | integrin, beta 4 | -0.0288566 |
| KRT8 | keratin 8, type II | -0.0280704 |
| NDRG1 | N-myc downstream regulated 1 | -0.0272773 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0269648 |
| FLNB | filamin B, beta | -0.0252711 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0249847 |
| INTS6 | integrator complex subunit 6 | -0.0244144 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0240207 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0239637 |
| COG5 | component of oligomeric golgi complex 5 | -0.0238356 |
| USP34 | ubiquitin specific peptidase 34 | -0.0235659 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.023156 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0231274 |
| S100A10 | S100 calcium binding protein A10 | -0.0221546 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0220958 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.021949 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0217684 |
| RPS25 | ribosomal protein S25 | -0.0215907 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0212277 |
| GNAS | GNAS complex locus | -0.0209863 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0203645 |
| DIAPH3 | diaphanous-related formin 3 | -0.020082 |
| ARF4 | ADP-ribosylation factor 4 | -0.0199267 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0193899 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0190613 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0190395 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0188416 |
| IGF2 | insulin-like growth factor 2 | -0.0185848 |
| ZNF207 | zinc finger protein 207 | -0.0185186 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0184156 |
| RASA3 | RAS p21 protein activator 3 | -0.0182399 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0182256 |
| PLEC | plectin | -0.0177109 |
| ANLN | anillin, actin binding protein | -0.0173099 |
| CDH13 | cadherin 13 | -0.0171817 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0166608 |
| RHEB | Ras homolog enriched in brain | -0.0166494 |
| TFRC | transferrin receptor | -0.0164994 |
| CDK8 | cyclin-dependent kinase 8 | -0.0163809 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0162656 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0159343 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.01591 |
| RPL28 | ribosomal protein L28 | -0.0157409 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0157176 |
| CCDC138 | coiled-coil domain containing 138 | -0.0156335 |
| RREB1 | ras responsive element binding protein 1 | -0.0155658 |
| CADM1 | cell adhesion molecule 1 | -0.0154047 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0153413 |
| RPL7A | ribosomal protein L7a | -0.0152768 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.015252 |
| RPL35A | ribosomal protein L35a | -0.0152117 |
| RPL27A | ribosomal protein L27a | -0.0150502 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0150092 |
| HM13 | histocompatibility (minor) 13 | -0.0149843 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0149623 |
| RPL36A | ribosomal protein L36a | -0.0148541 |
| TPM4 | tropomyosin 4 | -0.0148338 |
| MYO1D | myosin ID | -0.0147988 |
| RPL31 | ribosomal protein L31 | -0.0143998 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0143879 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0143821 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0143644 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0143154 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0142023 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0140794 |
| SQSTM1 | sequestosome 1 | -0.0138933 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0136748 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0136549 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.013645 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0136237 |
| S100A2 | S100 calcium binding protein A2 | -0.0135305 |
| INSIG2 | insulin induced gene 2 | -0.0135092 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0135047 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0134897 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0134675 |
| FRMD5 | FERM domain containing 5 | -0.0134435 |
| LAMA5 | laminin, alpha 5 | -0.0132369 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0132115 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0131764 |
| IER3 | immediate early response 3 | -0.013126 |
| LRRC8A | leucine rich repeat containing 8 family, member A | -0.013117 |
