AZD-7648_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-7648 perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-7648_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.262471
AKAP12 A kinase (PRKA) anchor protein 12 0.222752
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.198532
CD44 CD44 molecule (Indian blood group) 0.155762
STC1 stanniocalcin 1 0.133452
FN1 fibronectin 1 0.128023
MYH9 myosin, heavy chain 9, non-muscle 0.119211
TIMP1 TIMP metallopeptidase inhibitor 1 0.116139
MT2A metallothionein 2A 0.111254
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.108725
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.103391
MYO10 myosin X 0.0981788
TMSB10 thymosin beta 10 0.0802923
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.079795
NDRG1 N-myc downstream regulated 1 0.0769883
INHBA inhibin, beta A 0.0746847
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.074519
RPS6 ribosomal protein S6 0.0720523
RUNX1 runt-related transcription factor 1 0.0685845
PRRC2C proline-rich coiled-coil 2C 0.067764
ASPH aspartate beta-hydroxylase 0.067496
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0652303
CALD1 caldesmon 1 0.0612898
MSN moesin 0.058691
B2M beta-2-microglobulin 0.0579251
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0576027
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0550007
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0539006
FAM13A family with sequence similarity 13, member A 0.0517892
EMP1 epithelial membrane protein 1 0.0511852
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0501192
TRIO trio Rho guanine nucleotide exchange factor 0.0488962
POTEF POTE ankyrin domain family, member F 0.0482589
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0481275
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0449543
COL6A3 collagen, type VI, alpha 3 0.0440242
TLN1 talin 1 0.0419448
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0415855
ACTG1 actin gamma 1 0.0414762
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0413165
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0409804
DSPP dentin sialophosphoprotein 0.0408967
ANKRD28 ankyrin repeat domain 28 0.0405407
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0399771
FNDC3B fibronectin type III domain containing 3B 0.0395749
KMT2E lysine (K)-specific methyltransferase 2E 0.0394653
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0392636
KTN1 kinectin 1 (kinesin receptor) 0.038001
ENO1 enolase 1, (alpha) 0.0376905
RPS3 ribosomal protein S3 0.0372988
MACF1 microtubule-actin crosslinking factor 1 0.0364877
APLP2 amyloid beta (A4) precursor-like protein 2 0.0364173
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.036094
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0345387
MAML2 mastermind-like 2 (Drosophila) 0.0335487
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0332634
ALCAM activated leukocyte cell adhesion molecule 0.0327668
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0325092
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0323675
VEGFA vascular endothelial growth factor A 0.0321239
PFN1 profilin 1 0.0319341
NOTCH2 notch 2 0.0319299
TPI1 triosephosphate isomerase 1 0.0319164
LDHA lactate dehydrogenase A 0.0319162
SMAD3 SMAD family member 3 0.0315084
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0313126
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0312174
ANO6 anoctamin 6 0.030943
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0308544
DSCAM Down syndrome cell adhesion molecule 0.0307453
TAPBP TAP binding protein (tapasin) 0.0300636
LIMS1 LIM and senescent cell antigen-like domains 1 0.0297185
EIF1 eukaryotic translation initiation factor 1 0.0296172
CAPN2 calpain 2, (m/II) large subunit 0.0295263
DST dystonin 0.029429
RPL37A ribosomal protein L37a 0.0291323
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0291063
AKAP9 A kinase (PRKA) anchor protein 9 0.0290073
YBX1 Y box binding protein 1 0.0287512
ELL2 elongation factor, RNA polymerase II, 2 0.0287368
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0282392
TMSB4X thymosin beta 4, X-linked 0.027884
CTSB cathepsin B 0.0278226
BRD2 bromodomain containing 2 0.0275657
HSPA8 heat shock 70kDa protein 8 0.0275444
NAP1L1 nucleosome assembly protein 1-like 1 0.0274747
PCBP2 poly(rC) binding protein 2 0.0274623
MAP1B microtubule-associated protein 1B 0.0272924
LOXL2 lysyl oxidase-like 2 0.0272469
GOLGA4 golgin A4 0.0268384
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0267211
CSDE1 cold shock domain containing E1, RNA-binding 0.026576
CAVIN1 caveolae associated protein 1 0.0264014
EIF4A1 eukaryotic translation initiation factor 4A1 0.0263676
TPM3 tropomyosin 3 0.0263553
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0263458
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0262542
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0260266
RPS19 ribosomal protein S19 0.0258063
BHLHE40 basic helix-loop-helix family, member e40 0.0254206

decreased expression

Symbol Name Standardized Value
GREM1 gremlin 1, DAN family BMP antagonist -0.168314
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141112
PRKG1 protein kinase, cGMP-dependent, type I -0.120438
COL1A1 collagen, type I, alpha 1 -0.120073
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.120007
NPTX1 neuronal pentraxin I -0.0992551
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0898978
MMP1 matrix metallopeptidase 1 -0.0801971
FTL ferritin, light polypeptide -0.0798802
HMGA2 high mobility group AT-hook 2 -0.0737096
NCKAP5 NCK-associated protein 5 -0.0671982
OXR1 oxidation resistance 1 -0.0663595
TPT1 tumor protein, translationally-controlled 1 -0.0614768
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0575307
TFPI2 tissue factor pathway inhibitor 2 -0.053139
CEMIP cell migration inducing protein, hyaluronan binding -0.0483456
ABI3BP ABI family, member 3 (NESH) binding protein -0.046048
TPM4 tropomyosin 4 -0.0459964
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0459093
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0436111
FRMPD4 FERM and PDZ domain containing 4 -0.0430424
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0420476
MMP12 matrix metallopeptidase 12 -0.0412951
TGFBI transforming growth factor, beta-induced, 68kDa -0.0401814
SAMD3 sterile alpha motif domain containing 3 -0.0400883
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0398668
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0398177
ATP13A3 ATPase type 13A3 -0.0391175
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0389581
FBN1 fibrillin 1 -0.0362672
DGKI diacylglycerol kinase, iota -0.033484
IGFBP4 insulin-like growth factor binding protein 4 -0.0325753
MGST1 microsomal glutathione S-transferase 1 -0.0305217
DNER delta/notch-like EGF repeat containing -0.0293895
TXNRD1 thioredoxin reductase 1 -0.0288877
ITGA11 integrin, alpha 11 -0.0288824
GK glycerol kinase -0.0281952
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0275848
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0273015
FNDC3A fibronectin type III domain containing 3A -0.0272901
NPAS2 neuronal PAS domain protein 2 -0.0270328
CANX calnexin -0.026371
PRRX1 paired related homeobox 1 -0.0261274
CDH13 cadherin 13 -0.0259874
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0258953
STC2 stanniocalcin 2 -0.0255808
THBS1 thrombospondin 1 -0.0255707
COL8A1 collagen, type VIII, alpha 1 -0.0249348
WSB1 WD repeat and SOCS box containing 1 -0.0245208
SBF2 SET binding factor 2 -0.0239766
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0232581
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.023104
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0225063
PDE4D phosphodiesterase 4D, cAMP-specific -0.0221661
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0219581
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0212676
IL1B interleukin 1, beta -0.0211521
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0211447
EFCAB13 EF-hand calcium binding domain 13 -0.0206325
RPS24 ribosomal protein S24 -0.0202618
TMEM165 transmembrane protein 165 -0.0198362
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0198131
INTS6 integrator complex subunit 6 -0.0197953
MAML3 mastermind-like 3 (Drosophila) -0.0196662
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0196152
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0196043
PCDH9 protocadherin 9 -0.0188008
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0185807
DLC1 DLC1 Rho GTPase activating protein -0.0182283
ANKRD11 ankyrin repeat domain 11 -0.0182168
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0180468
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0180266
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0179594
MEIS1 Meis homeobox 1 -0.017749
PRR16 proline rich 16 -0.0176516
ITGA1 integrin, alpha 1 -0.0176128
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0175616
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.017494
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0172964
ARHGAP24 Rho GTPase activating protein 24 -0.0171361
WNT2B wingless-type MMTV integration site family, member 2B -0.0171152
PDE7B phosphodiesterase 7B -0.016881
MRPS6 mitochondrial ribosomal protein S6 -0.016847
IGF1R insulin-like growth factor 1 receptor -0.016809
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0167935
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -0.0166114
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0165744
PLIN2 perilipin 2 -0.0165043
PSD3 pleckstrin and Sec7 domain containing 3 -0.0164817
SOCS5 suppressor of cytokine signaling 5 -0.0163644
SEC24D SEC24 family member D -0.016315
KIAA1549L KIAA1549-like -0.0162654
PLAT plasminogen activator, tissue -0.0161843
TENT5A terminal nucleotidyltransferase 5A -0.0157693
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0156785
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.015474
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0154074
IPO5 importin 5 -0.0153082
GLG1 golgi glycoprotein 1 -0.0152759
SEC31A SEC31 homolog A (S. cerevisiae) -0.0151285