| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.189017 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.134111 |
| SLC39A11 | solute carrier family 39, member 11 | 0.128807 |
| CDH13 | cadherin 13 | 0.123197 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.113521 |
| CSTB | cystatin B (stefin B) | 0.0953218 |
| PODXL | podocalyxin-like | 0.095199 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0926675 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0887719 |
| HDAC9 | histone deacetylase 9 | 0.0800531 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0767536 |
| NAV2 | neuron navigator 2 | 0.0735546 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0650277 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0637965 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0630804 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0563461 |
| RND3 | Rho family GTPase 3 | 0.0559121 |
| NAV1 | neuron navigator 1 | 0.0553298 |
| NDRG1 | N-myc downstream regulated 1 | 0.0534732 |
| MSI2 | musashi RNA-binding protein 2 | 0.051768 |
| ANO6 | anoctamin 6 | 0.0510552 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0509964 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0509741 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0506878 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.050294 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0501744 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0492573 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0482322 |
| CCND1 | cyclin D1 | 0.0482191 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0460504 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0454056 |
| SQSTM1 | sequestosome 1 | 0.0454056 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0453236 |
| CENPF | centromere protein F, 350/400kDa | 0.0444097 |
| FNIP1 | folliculin interacting protein 1 | 0.0441384 |
| CEP170 | centrosomal protein 170kDa | 0.0440177 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.043853 |
| FRMD4A | FERM domain containing 4A | 0.0434054 |
| EGFR | epidermal growth factor receptor | 0.0430745 |
| AHNAK | AHNAK nucleoprotein | 0.0423021 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0418876 |
| EFNA5 | ephrin-A5 | 0.0416707 |
| DSG2 | desmoglein 2 | 0.0402663 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0395961 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0390718 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0378776 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0375606 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0374994 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0374663 |
| APP | amyloid beta (A4) precursor protein | 0.0374547 |
| COPA | coatomer protein complex, subunit alpha | 0.0367529 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0352469 |
| JMJD1C | jumonji domain containing 1C | 0.0347873 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0346354 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0344932 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0340423 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | 0.0337419 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0335273 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0331911 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0331264 |
| DOCK9 | dedicator of cytokinesis 9 | 0.0325697 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0325185 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0324291 |
| MSN | moesin | 0.0323492 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0315929 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.031205 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0305467 |
| MMP12 | matrix metallopeptidase 12 | 0.0299009 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0286777 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0282241 |
| GOLGB1 | golgin B1 | 0.0275371 |
| GOLGA4 | golgin A4 | 0.0274749 |
| DST | dystonin | 0.0273395 |
| CD109 | CD109 molecule | 0.0272248 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0269153 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0267362 |
| ASPH | aspartate beta-hydroxylase | 0.026671 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0266146 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0264244 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0264015 |
| KLF6 | Kruppel-like factor 6 | 0.0259622 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0258326 |
| ERBIN | erbb2 interacting protein | 0.0258265 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0255119 |
| AUTS2 | autism susceptibility candidate 2 | 0.0254552 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0254543 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0251146 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0250936 |
| MYO9B | myosin IXB | 0.0249327 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0248922 |
| FSTL1 | follistatin-like 1 | 0.0241133 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0239402 |
| GPC6 | glypican 6 | 0.0238236 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0235051 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0228011 |
| MYOF | myoferlin | 0.022776 |
| CRYM | crystallin, mu | 0.022773 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0224378 |
| TRAM2 | translocation associated membrane protein 2 | 0.022185 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0221094 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.151659 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.134432 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.134428 |
| PLAT | plasminogen activator, tissue | -0.105483 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0848874 |
| FBN1 | fibrillin 1 | -0.0836545 |
| VIM | vimentin | -0.0834458 |
| HLA-B | major histocompatibility complex, class I, B | -0.08333 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0787662 |
| COL1A2 | collagen, type I, alpha 2 | -0.0771084 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0709128 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0672993 |
| MT2A | metallothionein 2A | -0.065303 |
| PTMA | prothymosin, alpha | -0.0616784 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0586493 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0553074 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0552843 |
| B2M | beta-2-microglobulin | -0.0522987 |
| CAVIN1 | caveolae associated protein 1 | -0.0517597 |
| MX2 | MX dynamin-like GTPase 2 | -0.0498451 |
| S100A10 | S100 calcium binding protein A10 | -0.0479868 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0477867 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0431778 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0407943 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0388138 |
| LOX | lysyl oxidase | -0.0373987 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0370479 |
| COL3A1 | collagen, type III, alpha 1 | -0.0364353 |
| POTEF | POTE ankyrin domain family, member F | -0.0363729 |
| DCLK2 | doublecortin-like kinase 2 | -0.0353921 |
| PKM | pyruvate kinase, muscle | -0.0347762 |
| HLA-C | major histocompatibility complex, class I, C | -0.0333541 |
| SUCNR1 | succinate receptor 1 | -0.0330015 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0325929 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0313227 |
| PGK1 | phosphoglycerate kinase 1 | -0.0307867 |
| MEIS2 | Meis homeobox 2 | -0.0297459 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0293641 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0278901 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0277849 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0270442 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0268665 |
| FN1 | fibronectin 1 | -0.026581 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.025973 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0251968 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0251164 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0246613 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0246464 |
| RPS19 | ribosomal protein S19 | -0.0244603 |
| PRSS23 | protease, serine, 23 | -0.0244238 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.024205 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0239 |
| TRIM56 | tripartite motif containing 56 | -0.0231047 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0228307 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0227819 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0225978 |
| ACTN4 | actinin, alpha 4 | -0.022465 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0223317 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0223292 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0218892 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0218206 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0215976 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0212238 |
| HSPB1 | heat shock 27kDa protein 1 | -0.020762 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0204164 |
| NPR2 | natriuretic peptide receptor 2 | -0.0200636 |
| CD44 | CD44 molecule (Indian blood group) | -0.0196733 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0194785 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0193832 |
| TUBB | tubulin, beta class I | -0.0193477 |
| RIGI | RNA sensor RIG-I | -0.0189603 |
| HLA-E | major histocompatibility complex, class I, E | -0.018893 |
| S100A6 | S100 calcium binding protein A6 | -0.0187848 |
| CD99 | CD99 molecule | -0.018782 |
| KRT18 | keratin 18, type I | -0.0180574 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0180447 |
| RPL35A | ribosomal protein L35a | -0.0180371 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0178822 |
| TRIM22 | tripartite motif containing 22 | -0.017532 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0174464 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0174175 |
| TMOD1 | tropomodulin 1 | -0.0172745 |
| CALR | calreticulin | -0.0172623 |
| SEPTIN7 | septin 7 | -0.0170859 |
| BSG | basigin (Ok blood group) | -0.0170508 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0169937 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0169914 |
| TXNIP | thioredoxin interacting protein | -0.0169446 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0167801 |
| ANXA2 | annexin A2 | -0.0167601 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0167536 |
| FAM162A | family with sequence similarity 162, member A | -0.016432 |
| PMP22 | peripheral myelin protein 22 | -0.0164144 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0162939 |
| TRIM5 | tripartite motif containing 5 | -0.016236 |
| IFI44 | interferon-induced protein 44 | -0.0160189 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0160156 |
| ADAR | adenosine deaminase, RNA-specific | -0.0159686 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0159461 |
| TUBA1B | tubulin, alpha 1b | -0.0159316 |
