| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.364667 |
| NLGN1 | neuroligin 1 | 0.187993 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.17772 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.133342 |
| RASAL2 | RAS protein activator like 2 | 0.120821 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.118143 |
| VIM | vimentin | 0.108415 |
| ANKRD12 | ankyrin repeat domain 12 | 0.108199 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.1058 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0942356 |
| JMJD1C | jumonji domain containing 1C | 0.0899805 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0704635 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0674822 |
| YBX3 | Y box binding protein 3 | 0.064853 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0648155 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0640358 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0637614 |
| DST | dystonin | 0.0617129 |
| MMP12 | matrix metallopeptidase 12 | 0.0611693 |
| MGAT4C | MGAT4 family, member C | 0.0602735 |
| PCDH7 | protocadherin 7 | 0.0597713 |
| HMGA2 | high mobility group AT-hook 2 | 0.0593922 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0576827 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0555205 |
| EHBP1 | EH domain binding protein 1 | 0.0553715 |
| ANXA1 | annexin A1 | 0.0552028 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0549712 |
| IPO7 | importin 7 | 0.0548528 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0505332 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0474936 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0468139 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0462107 |
| AREG | amphiregulin | 0.0446382 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0441303 |
| TXNRD1 | thioredoxin reductase 1 | 0.0439468 |
| YAP1 | Yes-associated protein 1 | 0.0438825 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0435252 |
| ZNF804A | zinc finger protein 804A | 0.0427523 |
| TENM3 | teneurin transmembrane protein 3 | 0.0416871 |
| VCAN | versican | 0.0413556 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0408744 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0404584 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0403832 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0401544 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.039599 |
| ASPH | aspartate beta-hydroxylase | 0.0394452 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0390368 |
| PCDH9 | protocadherin 9 | 0.038995 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0380117 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0370507 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0364679 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.035686 |
| EPHA5 | EPH receptor A5 | 0.0356502 |
| CCN2 | cellular communication network factor 2 | 0.0355612 |
| VMP1 | vacuole membrane protein 1 | 0.0352193 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.034491 |
| CLTC | clathrin, heavy chain (Hc) | 0.0331439 |
| SETX | senataxin | 0.0328718 |
| PRDX1 | peroxiredoxin 1 | 0.0326327 |
| USP34 | ubiquitin specific peptidase 34 | 0.032613 |
| POTEF | POTE ankyrin domain family, member F | 0.0319474 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0317424 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0310736 |
| ACTG1 | actin gamma 1 | 0.0308544 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0308491 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0307679 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.030603 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0304561 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0296227 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0295481 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0292928 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | 0.0292516 |
| AFF4 | AF4/FMR2 family, member 4 | 0.029201 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0286261 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0286256 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0277515 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0275554 |
| NEGR1 | neuronal growth regulator 1 | 0.0274669 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.027466 |
| FNIP1 | folliculin interacting protein 1 | 0.0272926 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0272661 |
| PRR16 | proline rich 16 | 0.0272089 |
| UBC | ubiquitin C | 0.0270647 |
| MYPN | myopalladin | 0.0268145 |
| EGFR | epidermal growth factor receptor | 0.0266345 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0265893 |
| DSG2 | desmoglein 2 | 0.0265236 |
| USP53 | ubiquitin specific peptidase 53 | 0.026482 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0263347 |
| NRXN3 | neurexin 3 | 0.0262636 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0262508 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0259276 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0252989 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0250727 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0249668 |
| INTS6 | integrator complex subunit 6 | 0.0248915 |
| NAV3 | neuron navigator 3 | 0.0248879 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0247237 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.024619 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.024348 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.0648217 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0635495 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0607287 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0514199 |
| MKI67 | marker of proliferation Ki-67 | -0.0436066 |
| ECT2 | epithelial cell transforming 2 | -0.0412279 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0411875 |
| CENPF | centromere protein F, 350/400kDa | -0.0394531 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0386401 |
| KIF5B | kinesin family member 5B | -0.038149 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.036619 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0323206 |
| CENPE | centromere protein E, 312kDa | -0.0309095 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0304656 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0284238 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0274946 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0273714 |
| CCNL1 | cyclin L1 | -0.0265096 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0261337 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0242128 |
| RRM2 | ribonucleotide reductase M2 | -0.0241631 |
| PRR11 | proline rich 11 | -0.0234045 |
| CEP192 | centrosomal protein 192kDa | -0.0231715 |
| TPX2 | TPX2, microtubule-associated | -0.0231451 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0231086 |
| NDC80 | NDC80 kinetochore complex component | -0.0230164 |
| PNN | pinin, desmosome associated protein | -0.0227509 |
| RPLP2 | ribosomal protein, large, P2 | -0.0224961 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0223272 |
| WDR43 | WD repeat domain 43 | -0.0216969 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0216881 |
| KIF18B | kinesin family member 18B | -0.0216414 |
| VCL | vinculin | -0.0216043 |
| R3HDM1 | R3H domain containing 1 | -0.0208819 |
| CKAP5 | cytoskeleton associated protein 5 | -0.020623 |
| TNPO1 | transportin 1 | -0.0205197 |
| NKTR | natural killer cell triggering receptor | -0.0203326 |
| BTG3 | BTG family, member 3 | -0.0202202 |
| MYL12B | myosin, light chain 12B, regulatory | -0.02022 |
| THOC2 | THO complex 2 | -0.0200722 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.0199299 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0198262 |
| CDCA2 | cell division cycle associated 2 | -0.01973 |
| TMEM41B | transmembrane protein 41B | -0.0197026 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0196367 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -0.0194605 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0193601 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0191797 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0191536 |
| KIAA1328 | KIAA1328 | -0.0191429 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0189893 |
| RPS12 | ribosomal protein S12 | -0.0187518 |
| CCND1 | cyclin D1 | -0.018417 |
| TUBA1B | tubulin, alpha 1b | -0.018382 |
| IPMK | inositol polyphosphate multikinase | -0.018283 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0182781 |
| RPL35A | ribosomal protein L35a | -0.0182566 |
| DIAPH3 | diaphanous-related formin 3 | -0.0181368 |
| AXIN2 | axin 2 | -0.0180424 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0179424 |
| RPS21 | ribosomal protein S21 | -0.0178752 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0178651 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0178491 |
| GASK1B | golgi associated kinase 1B | -0.0178035 |
| STIL | SCL/TAL1 interrupting locus | -0.0176227 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0175939 |
| WDR45B | WD repeat domain 45B | -0.0175625 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.0172955 |
| OGA | O-GlcNAcase | -0.0171728 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0170915 |
| DEPDC1B | DEP domain containing 1B | -0.017073 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0170571 |
| KIF4A | kinesin family member 4A | -0.0170099 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.016853 |
| NEK7 | NIMA-related kinase 7 | -0.0165681 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0164053 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0163663 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0163459 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0163133 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0161059 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.016012 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0160048 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0159955 |
| HELLS | helicase, lymphoid-specific | -0.0159747 |
| NCOR1 | nuclear receptor corepressor 1 | -0.015961 |
| RPL26 | ribosomal protein L26 | -0.0159122 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0159112 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0156324 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0156121 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0154866 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0152334 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.015072 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0148732 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0148093 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0147996 |
| KNL1 | kinetochore scaffold 1 | -0.0147421 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0147252 |
| IMMT | inner membrane protein, mitochondrial | -0.0147144 |
| GOLGA4 | golgin A4 | -0.0147129 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0146429 |
