| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAV2 | neuron navigator 2 | 0.117734 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0940766 |
| CD44 | CD44 molecule (Indian blood group) | 0.093579 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0894237 |
| GPC6 | glypican 6 | 0.083009 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0756274 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0740046 |
| RND3 | Rho family GTPase 3 | 0.0713024 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0699877 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0695824 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0667917 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0667811 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0645662 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0643942 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0637832 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0617256 |
| SPAG9 | sperm associated antigen 9 | 0.0610102 |
| MSN | moesin | 0.0583119 |
| COG5 | component of oligomeric golgi complex 5 | 0.0558571 |
| SUCO | SUN domain containing ossification factor | 0.0545977 |
| GOLGB1 | golgin B1 | 0.0533429 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0496439 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0484425 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0476899 |
| COG6 | component of oligomeric golgi complex 6 | 0.0472226 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0468052 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0467771 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0459654 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0453038 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0452996 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0445208 |
| CRY1 | cryptochrome circadian clock 1 | 0.0429178 |
| NUP98 | nucleoporin 98kDa | 0.0418232 |
| RUNX1 | runt-related transcription factor 1 | 0.0404828 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0402627 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0392049 |
| FAM107B | family with sequence similarity 107, member B | 0.0389332 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0383565 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0382102 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0381362 |
| SEPTIN9 | septin 9 | 0.038006 |
| MYADM | myeloid-associated differentiation marker | 0.0378821 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0366457 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0365828 |
| HM13 | histocompatibility (minor) 13 | 0.0356425 |
| MLF1 | myeloid leukemia factor 1 | 0.0351344 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.035014 |
| INTS6 | integrator complex subunit 6 | 0.0348255 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0343924 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0341834 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0340773 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0339478 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0334204 |
| MCL1 | myeloid cell leukemia 1 | 0.0332635 |
| GPR176 | G protein-coupled receptor 176 | 0.0331777 |
| MT2A | metallothionein 2A | 0.0330164 |
| VEGFA | vascular endothelial growth factor A | 0.0326535 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0325632 |
| VMP1 | vacuole membrane protein 1 | 0.0324669 |
| DENND4A | DENN/MADD domain containing 4A | 0.0320536 |
| SEC24D | SEC24 family member D | 0.0319793 |
| CADM1 | cell adhesion molecule 1 | 0.0317596 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0316856 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.031394 |
| CLTC | clathrin, heavy chain (Hc) | 0.031211 |
| TMSB10 | thymosin beta 10 | 0.0311508 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0311418 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0308709 |
| PLEC | plectin | 0.0303092 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0302567 |
| PMM2 | phosphomannomutase 2 | 0.0301149 |
| TPM3 | tropomyosin 3 | 0.0299967 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0297653 |
| FNIP1 | folliculin interacting protein 1 | 0.0295411 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0293651 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0293445 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0292365 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0291892 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0287838 |
| RPS2 | ribosomal protein S2 | 0.0287238 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0284964 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0284814 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0284447 |
| ITSN2 | intersectin 2 | 0.0282345 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0280543 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0280113 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0275114 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.027475 |
| LYST | lysosomal trafficking regulator | 0.0274603 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0273708 |
| MYO1E | myosin IE | 0.0273343 |
| ATF6 | activating transcription factor 6 | 0.0273334 |
| SBF2 | SET binding factor 2 | 0.0272996 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0272853 |
| NOP58 | NOP58 ribonucleoprotein | 0.0272634 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.027223 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0270402 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0269629 |
| COPA | coatomer protein complex, subunit alpha | 0.0269093 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0268365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | -0.25349 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.245041 |
| CP | ceruloplasmin (ferroxidase) | -0.151023 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.118429 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.105103 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.104936 |
| TXNRD1 | thioredoxin reductase 1 | -0.0869178 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0770097 |
| GLIS3 | GLIS family zinc finger 3 | -0.0663506 |
| CAVIN1 | caveolae associated protein 1 | -0.0583607 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0576531 |
| HLA-B | major histocompatibility complex, class I, B | -0.0565807 |
| CA12 | carbonic anhydrase XII | -0.0565417 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0532059 |
| PTMA | prothymosin, alpha | -0.0506004 |
| CALR | calreticulin | -0.0475728 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0451509 |
| FRMD4A | FERM domain containing 4A | -0.0429094 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0421195 |
| RRBP1 | ribosome binding protein 1 | -0.0419683 |
| PLIN2 | perilipin 2 | -0.0410203 |
| ANXA4 | annexin A4 | -0.0408325 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0403887 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0393524 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0371656 |
| FN1 | fibronectin 1 | -0.0371099 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0359744 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0339874 |
| APOL1 | apolipoprotein L, 1 | -0.0338817 |
| RPL35A | ribosomal protein L35a | -0.0336266 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.033071 |
| HMGB1 | high mobility group box 1 | -0.0329952 |
| VIM | vimentin | -0.0317513 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0313047 |
| PTGR1 | prostaglandin reductase 1 | -0.030752 |
| RAI14 | retinoic acid induced 14 | -0.0306606 |
| TPM4 | tropomyosin 4 | -0.0305399 |
| RPS6 | ribosomal protein S6 | -0.0304587 |
| FTL | ferritin, light polypeptide | -0.0295898 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0292768 |
| TPM1 | tropomyosin 1 (alpha) | -0.0280908 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0280759 |
| LAMB3 | laminin, beta 3 | -0.0267344 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0260901 |
| RRM2 | ribonucleotide reductase M2 | -0.0255368 |
| MKI67 | marker of proliferation Ki-67 | -0.0252856 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0251075 |
| HLA-E | major histocompatibility complex, class I, E | -0.024643 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0243579 |
| RIGI | RNA sensor RIG-I | -0.0239633 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0236938 |
| NFIB | nuclear factor I/B | -0.0234341 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0234324 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0232147 |
| NRP1 | neuropilin 1 | -0.022862 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0224025 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0224012 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0223855 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.0223441 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0223141 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0221605 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0220146 |
| XAF1 | XIAP associated factor 1 | -0.021832 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.021789 |
| OXR1 | oxidation resistance 1 | -0.0217505 |
| BRCA1 | breast cancer 1, early onset | -0.0216894 |
| RNF213 | ring finger protein 213 | -0.0214742 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0213738 |
| AOPEP | aminopeptidase O (putative) | -0.0209609 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0209174 |
| LOXL2 | lysyl oxidase-like 2 | -0.020904 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.020338 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.020321 |
| RPLP1 | ribosomal protein, large, P1 | -0.0201881 |
| RTN4 | reticulon 4 | -0.0195964 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.019434 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0191545 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.019009 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | -0.0189661 |
| MAP1B | microtubule-associated protein 1B | -0.0189376 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0188335 |
| ARF1 | ADP-ribosylation factor 1 | -0.0186782 |
| PXDN | peroxidasin | -0.0186043 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.018563 |
| ENO1 | enolase 1, (alpha) | -0.0185518 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0185048 |
| TMEM123 | transmembrane protein 123 | -0.0183633 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0183505 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0182025 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0181511 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | -0.0180971 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0180349 |
| TRIM56 | tripartite motif containing 56 | -0.0180276 |
| SRP72 | signal recognition particle 72kDa | -0.0178268 |
| CD70 | CD70 molecule | -0.0176014 |
| GDA | guanine deaminase | -0.0175136 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0175006 |
| ANXA2 | annexin A2 | -0.0174801 |
| RPS8 | ribosomal protein S8 | -0.0174511 |
| HLA-C | major histocompatibility complex, class I, C | -0.0174223 |
