| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.325026 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.177568 |
| VIM | vimentin | 0.17649 |
| EFNA5 | ephrin-A5 | 0.161232 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.123351 |
| ACTG1 | actin gamma 1 | 0.114789 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.101494 |
| DOCK5 | dedicator of cytokinesis 5 | 0.094154 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0885585 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0849224 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0809363 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0798275 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0789695 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0730502 |
| EGFR | epidermal growth factor receptor | 0.0726762 |
| HMGA2 | high mobility group AT-hook 2 | 0.0715308 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0691952 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0689859 |
| GOLGB1 | golgin B1 | 0.0664674 |
| SQSTM1 | sequestosome 1 | 0.0659221 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.064732 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0647042 |
| FNIP1 | folliculin interacting protein 1 | 0.0645676 |
| EXT1 | exostosin glycosyltransferase 1 | 0.059572 |
| IGF1R | insulin-like growth factor 1 receptor | 0.059155 |
| RND3 | Rho family GTPase 3 | 0.0584181 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0582304 |
| EHBP1 | EH domain binding protein 1 | 0.0579175 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0572178 |
| SP100 | SP100 nuclear antigen | 0.0569241 |
| CA12 | carbonic anhydrase XII | 0.0555172 |
| MYO1E | myosin IE | 0.0538919 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0527818 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0526609 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0524104 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0521759 |
| DUSP16 | dual specificity phosphatase 16 | 0.0521465 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0504471 |
| AUTS2 | autism susceptibility candidate 2 | 0.0499775 |
| RAD51B | RAD51 paralog B | 0.0495907 |
| AHNAK | AHNAK nucleoprotein | 0.0493501 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0483562 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0483525 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0469869 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0467604 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0463567 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0463069 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0457932 |
| USP47 | ubiquitin specific peptidase 47 | 0.0454306 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0452471 |
| RNF213 | ring finger protein 213 | 0.045055 |
| CUX1 | cut-like homeobox 1 | 0.044934 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | 0.0444075 |
| MYO9A | myosin IXA | 0.0439876 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0435586 |
| MAP7 | microtubule-associated protein 7 | 0.043534 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0433272 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0427442 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0426106 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.042134 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0418571 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0415568 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0415422 |
| FMNL2 | formin-like 2 | 0.0413173 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0406008 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0396 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.038971 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0387651 |
| NDRG1 | N-myc downstream regulated 1 | 0.0385089 |
| AADAC | arylacetamide deacetylase | 0.0381651 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0377351 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0371557 |
| MSI2 | musashi RNA-binding protein 2 | 0.0369548 |
| TMSB10 | thymosin beta 10 | 0.0365075 |
| MYADM | myeloid-associated differentiation marker | 0.0360809 |
| EXOC4 | exocyst complex component 4 | 0.0352798 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0352034 |
| PRKCA | protein kinase C, alpha | 0.0351769 |
| TNS1 | tensin 1 | 0.0348141 |
| BPTF | bromodomain PHD finger transcription factor | 0.0345416 |
| CTSL | cathepsin L | 0.0344612 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0342764 |
| ANXA1 | annexin A1 | 0.0336621 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0334956 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0330749 |
| LMO7 | LIM domain 7 | 0.0329648 |
| RHCG | Rh family, C glycoprotein | 0.0328344 |
| S100A6 | S100 calcium binding protein A6 | 0.0319238 |
| KYNU | kynureninase | 0.0317172 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0313527 |
| TNS3 | tensin 3 | 0.0310486 |
| ATXN1 | ataxin 1 | 0.0309733 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0309271 |
| ETNK1 | ethanolamine kinase 1 | 0.0308243 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0307695 |
| CCDC88A | coiled-coil domain containing 88A | 0.0303039 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0302069 |
| JMJD1C | jumonji domain containing 1C | 0.0301326 |
| PALLD | palladin, cytoskeletal associated protein | 0.029953 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0298479 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.17802 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.108629 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0881244 |
| USP3 | ubiquitin specific peptidase 3 | -0.0846382 |
| SMAD3 | SMAD family member 3 | -0.0687915 |
| TXNRD1 | thioredoxin reductase 1 | -0.0646032 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0615695 |
| RTN4 | reticulon 4 | -0.0599075 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0590811 |
| SPAG9 | sperm associated antigen 9 | -0.0557112 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0550075 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0532686 |
| HELZ | helicase with zinc finger | -0.050687 |
| NUP58 | nucleoporin 58 | -0.0489001 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0484063 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0477569 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0460937 |
| WDR43 | WD repeat domain 43 | -0.0450289 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0444477 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0443793 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0436678 |
| MT2A | metallothionein 2A | -0.0430979 |
| GOLGA4 | golgin A4 | -0.0427501 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0426132 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0425028 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0417512 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0416787 |
| ECT2 | epithelial cell transforming 2 | -0.0402157 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0398951 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0398804 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0397597 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0386697 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0371479 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0369646 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | -0.0364652 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0337881 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0335145 |
| ASPH | aspartate beta-hydroxylase | -0.0334573 |
| WDR45B | WD repeat domain 45B | -0.0331384 |
| PTMA | prothymosin, alpha | -0.0327291 |
| EREG | epiregulin | -0.032552 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0313548 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0311967 |
| RNF145 | ring finger protein 145 | -0.0301176 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0299049 |
| CCNL1 | cyclin L1 | -0.0298739 |
| OGA | O-GlcNAcase | -0.0297596 |
| RBM25 | RNA binding motif protein 25 | -0.029739 |
| WWC1 | WW and C2 domain containing 1 | -0.0294598 |
| OLA1 | Obg-like ATPase 1 | -0.0291927 |
| ITGB5 | integrin, beta 5 | -0.0291844 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.029044 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0289724 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0289584 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0288261 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0283987 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0276706 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0270027 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0269351 |
| RNF24 | ring finger protein 24 | -0.0267778 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0267472 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0266912 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0265108 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0263041 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0262774 |
| SUCO | SUN domain containing ossification factor | -0.0260579 |
| ZNF292 | zinc finger protein 292 | -0.0260529 |
| NBAS | neuroblastoma amplified sequence | -0.0255613 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.025349 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0253246 |
| ANLN | anillin, actin binding protein | -0.024839 |
| ANXA2 | annexin A2 | -0.0247893 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.0246033 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0245829 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.024504 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0242626 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0241106 |
| CORO1C | coronin, actin binding protein, 1C | -0.0240265 |
| MYO1B | myosin IB | -0.0238851 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0237444 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0236621 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0235184 |
| SETD5 | SET domain containing 5 | -0.0234911 |
| NOP58 | NOP58 ribonucleoprotein | -0.0233678 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0233299 |
| MT1X | metallothionein 1X | -0.0231878 |
| FLNB | filamin B, beta | -0.023129 |
| TGM2 | transglutaminase 2 | -0.0230071 |
| BCL2L1 | BCL2-like 1 | -0.0229058 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0222089 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0221875 |
| SEC24A | SEC24 family member A | -0.0220894 |
| CA8 | carbonic anhydrase VIII | -0.0219913 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0219268 |
| TOP1 | topoisomerase (DNA) I | -0.0219015 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0218474 |
| SRP54 | signal recognition particle 54kDa | -0.0217816 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0216655 |
| SP3 | Sp3 transcription factor | -0.0214786 |
| ATP13A3 | ATPase type 13A3 | -0.0214545 |
