AZD-8055_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in AN3 CA cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the AZD-8055_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.366876
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.230604
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.15099
TRIO trio Rho guanine nucleotide exchange factor 0.117167
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.111944
RPS2 ribosomal protein S2 0.106701
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.103523
TSHZ2 teashirt zinc finger homeobox 2 0.101936
RPS6 ribosomal protein S6 0.0835815
VEGFA vascular endothelial growth factor A 0.0789111
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0784501
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0780351
PABPC1 poly(A) binding protein, cytoplasmic 1 0.077413
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0759803
EEF2 eukaryotic translation elongation factor 2 0.075131
LDHA lactate dehydrogenase A 0.0734258
ENO1 enolase 1, (alpha) 0.0695823
IPO7 importin 7 0.0671702
RPS8 ribosomal protein S8 0.0624648
MYOF myoferlin 0.0619038
MGP matrix Gla protein 0.058745
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0581145
HMGA1 high mobility group AT-hook 1 0.0574632
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0567743
RPL3 ribosomal protein L3 0.0551413
ACTG1 actin gamma 1 0.0547735
HMGA2 high mobility group AT-hook 2 0.0532035
RPS12 ribosomal protein S12 0.0526949
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.051442
IER3 immediate early response 3 0.0511251
RPS23 ribosomal protein S23 0.0496766
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0494298
SFTPA2 surfactant protein A2 0.0489025
PTMA prothymosin, alpha 0.0479231
FNIP1 folliculin interacting protein 1 0.0477682
SAMD4A sterile alpha motif domain containing 4A 0.047329
POTEF POTE ankyrin domain family, member F 0.0465031
RPL37A ribosomal protein L37a 0.0461469
CANX calnexin 0.0453789
UTRN utrophin 0.0452638
RACK1 receptor for activated C kinase 1 0.0450082
RPLP0 ribosomal protein, large, P0 0.0450023
SET SET nuclear proto-oncogene 0.0443532
HSPA8 heat shock 70kDa protein 8 0.0442688
RPS13 ribosomal protein S13 0.0436132
ZFP36L1 ZFP36 ring finger protein-like 1 0.043451
CDK6 cyclin-dependent kinase 6 0.0428499
RPL5 ribosomal protein L5 0.0419077
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0416796
ADM adrenomedullin 0.0414964
RPLP1 ribosomal protein, large, P1 0.0414693
RPL26 ribosomal protein L26 0.0413816
RPL11 ribosomal protein L11 0.0410034
UBC ubiquitin C 0.0405512
RPS3 ribosomal protein S3 0.0399763
SOX4 SRY (sex determining region Y)-box 4 0.0389666
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0385463
ATP11A ATPase, class VI, type 11A 0.0383768
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0383745
THBS1 thrombospondin 1 0.0379306
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0378175
SPAG9 sperm associated antigen 9 0.0377254
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0377019
RPS25 ribosomal protein S25 0.0374453
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.036675
RPS14 ribosomal protein S14 0.036179
RPL12 ribosomal protein L12 0.035914
RPLP2 ribosomal protein, large, P2 0.0353845
RPS19 ribosomal protein S19 0.0352922
SERBP1 SERPINE1 mRNA binding protein 1 0.0352684
RPL34 ribosomal protein L34 0.0346717
CLTC clathrin, heavy chain (Hc) 0.0345396
TMSB4X thymosin beta 4, X-linked 0.0345366
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0345253
GOLGA4 golgin A4 0.0344651
DSTN destrin (actin depolymerizing factor) 0.0343938
IGF2 insulin-like growth factor 2 0.0338629
AFF4 AF4/FMR2 family, member 4 0.0334488
RPS4X ribosomal protein S4, X-linked 0.0332849
FOXC1 forkhead box C1 0.0328934
PRRC2C proline-rich coiled-coil 2C 0.0325923
PCBP2 poly(rC) binding protein 2 0.0324653
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0321074
RPS20 ribosomal protein S20 0.0310451
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0309773
EIF1 eukaryotic translation initiation factor 1 0.0306272
RPS18 ribosomal protein S18 0.0302986
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0298033
PKM pyruvate kinase, muscle 0.0296825
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0296327
FER fer (fps/fes related) tyrosine kinase 0.0293959
RPL15 ribosomal protein L15 0.0291474
ANO6 anoctamin 6 0.0291101
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0290937
SQSTM1 sequestosome 1 0.0288765
CSNK1A1 casein kinase 1, alpha 1 0.0287848
RPL31 ribosomal protein L31 0.0286246
RPL7 ribosomal protein L7 0.0283706
MXI1 MAX interactor 1, dimerization protein 0.0283688
CKAP5 cytoskeleton associated protein 5 0.0281697

decreased expression

Symbol Name Standardized Value
MEOX2 mesenchyme homeobox 2 -0.0889419
PDE4D phosphodiesterase 4D, cAMP-specific -0.0883285
TPK1 thiamin pyrophosphokinase 1 -0.0882903
PRKG1 protein kinase, cGMP-dependent, type I -0.0748088
NFIA nuclear factor I/A -0.0490729
MEST mesoderm specific transcript -0.0478592
PEG10 paternally expressed 10 -0.0466125
MARCHF6 membrane associated ring-CH-type finger 6 -0.0453667
ZEB1 zinc finger E-box binding homeobox 1 -0.042034
MIS18BP1 MIS18 binding protein 1 -0.0359155
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.034967
SMC4 structural maintenance of chromosomes 4 -0.0347944
SSBP2 single-stranded DNA binding protein 2 -0.0318643
KLHDC10 kelch domain containing 10 -0.0304556
FBXO11 F-box protein 11 -0.0304084
LCORL ligand dependent nuclear receptor corepressor-like -0.0303988
FBXL7 F-box and leucine-rich repeat protein 7 -0.0293613
MTUS1 microtubule associated tumor suppressor 1 -0.0290894
ZMYND8 zinc finger, MYND-type containing 8 -0.0278596
U2SURP U2 snRNP-associated SURP domain containing -0.0273983
RHEB Ras homolog enriched in brain -0.0271937
ARB2A ARB2 cotranscriptional regulator A -0.0271585
SRPK2 SRSF protein kinase 2 -0.0270355
MSI2 musashi RNA-binding protein 2 -0.0261227
CENPE centromere protein E, 312kDa -0.0243203
QKI QKI, KH domain containing, RNA binding -0.0238395
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0236813
PUM2 pumilio RNA-binding family member 2 -0.0236582
RFC3 replication factor C (activator 1) 3, 38kDa -0.02325
SEPTIN11 septin 11 -0.0232255
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0232216
TET1 tet methylcytosine dioxygenase 1 -0.0230315
SCLT1 sodium channel and clathrin linker 1 -0.022964
ECT2 epithelial cell transforming 2 -0.022809
TET2 tet methylcytosine dioxygenase 2 -0.0221868
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -0.021436
GPC6 glypican 6 -0.0212747
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.021156
FGFR1 fibroblast growth factor receptor 1 -0.0210347
CPNE8 copine VIII -0.020976
PDS5B PDS5 cohesin associated factor B -0.0208912
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.020839
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0207565
KIF11 kinesin family member 11 -0.0205139
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.019956
RFX7 regulatory factor X, 7 -0.0198956
AK1 adenylate kinase 1 -0.0198888
R3HDM2 R3H domain containing 2 -0.0198681
NHSL1 NHS-like 1 -0.0198578
TTC28 tetratricopeptide repeat domain 28 -0.0198339
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0197787
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0195377
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0193525
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0193179
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0193175
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0191477
FCHSD2 FCH and double SH3 domains 2 -0.0191089
CDCA2 cell division cycle associated 2 -0.0190818
PRKCE protein kinase C, epsilon -0.0190016
MMS22L MMS22-like, DNA repair protein -0.018772
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0186802
MBD5 methyl-CpG binding domain protein 5 -0.0184947
ZNF292 zinc finger protein 292 -0.0184911
PHF14 PHD finger protein 14 -0.0183977
ARL15 ADP-ribosylation factor-like 15 -0.0182758
SENP6 SUMO1/sentrin specific peptidase 6 -0.018199
NPR2 natriuretic peptide receptor 2 -0.0181675
TRIM9 tripartite motif containing 9 -0.0179749
TAS2R14 taste receptor, type 2, member 14 -0.0179347
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0179327
RNF145 ring finger protein 145 -0.0179017
TFRC transferrin receptor -0.0175806
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0175021
GCC2 GRIP and coiled-coil domain containing 2 -0.0174625
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0174576
TP53 tumor protein p53 -0.0172186
DEPDC1B DEP domain containing 1B -0.0172124
PDGFC platelet derived growth factor C -0.0170929
NBEA neurobeachin -0.0170305
PAXBP1 PAX3 and PAX7 binding protein 1 -0.0169034
DLG1 discs, large homolog 1 (Drosophila) -0.0168703
MAPK8 mitogen-activated protein kinase 8 -0.0167193
FGFR2 fibroblast growth factor receptor 2 -0.0166345
FHIP2A FHF complex subunit HOOK interacting protein 2A -0.0166014
COTL1 coactosin-like F-actin binding protein 1 -0.016587
RBM39 RNA binding motif protein 39 -0.0165779
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0165723
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -0.0160317
ZC3H13 zinc finger CCCH-type containing 13 -0.0159753
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0159739
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0159464
CD46 CD46 molecule, complement regulatory protein -0.0158246
CENPP centromere protein P -0.0157446
KIF20B kinesin family member 20B -0.015678
TMPO thymopoietin -0.0156608
EGFR epidermal growth factor receptor -0.0155823
RAB6A RAB6A, member RAS oncogene family -0.0155683
TPST1 tyrosylprotein sulfotransferase 1 -0.0155603
R3HDM1 R3H domain containing 1 -0.0155364
SOBP sine oculis binding protein homolog (Drosophila) -0.0155338