| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.225795 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0889557 |
| LAMB3 | laminin, beta 3 | 0.0833918 |
| MMP1 | matrix metallopeptidase 1 | 0.0787156 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0725936 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.068322 |
| HSPA8 | heat shock 70kDa protein 8 | 0.066223 |
| EFNA5 | ephrin-A5 | 0.0590321 |
| TXNRD1 | thioredoxin reductase 1 | 0.0588986 |
| DSPP | dentin sialophosphoprotein | 0.0578207 |
| FMNL2 | formin-like 2 | 0.0574733 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.0565803 |
| BMP6 | bone morphogenetic protein 6 | 0.0562816 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0533864 |
| LAMC2 | laminin, gamma 2 | 0.0517986 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.050958 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0504094 |
| SGMS2 | sphingomyelin synthase 2 | 0.0476101 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0459855 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0446234 |
| NDRG1 | N-myc downstream regulated 1 | 0.0443496 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0428879 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0425484 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0422843 |
| SMAD3 | SMAD family member 3 | 0.0414951 |
| MCL1 | myeloid cell leukemia 1 | 0.0408475 |
| PARD3 | par-3 family cell polarity regulator | 0.0382192 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0375062 |
| DSG2 | desmoglein 2 | 0.0374868 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0373634 |
| STC1 | stanniocalcin 1 | 0.0369603 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0357913 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0340102 |
| PLEC | plectin | 0.0339752 |
| RUNX1 | runt-related transcription factor 1 | 0.0328098 |
| SNX9 | sorting nexin 9 | 0.0321392 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0313588 |
| SEPTIN10 | septin 10 | 0.0311957 |
| CLMP | CXADR-like membrane protein | 0.0311263 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0310135 |
| RESF1 | retroelement silencing factor 1 | 0.0307098 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0306665 |
| CTSB | cathepsin B | 0.0303692 |
| FAM107B | family with sequence similarity 107, member B | 0.0300879 |
| RPS2 | ribosomal protein S2 | 0.0298909 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.029318 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0290836 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.029032 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.0281226 |
| CDCP1 | CUB domain containing protein 1 | 0.0272017 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0270658 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.027017 |
| OSMR | oncostatin M receptor | 0.0268011 |
| SEPTIN9 | septin 9 | 0.0265277 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0259509 |
| EGFR | epidermal growth factor receptor | 0.0258954 |
| TGM2 | transglutaminase 2 | 0.0256539 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0247091 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0242568 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0236513 |
| DOCK5 | dedicator of cytokinesis 5 | 0.023372 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0231506 |
| MYO5B | myosin VB | 0.0230761 |
| APP | amyloid beta (A4) precursor protein | 0.0226244 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0226207 |
| ZNF83 | zinc finger protein 83 | 0.0224174 |
| SMNDC1 | survival motor neuron domain containing 1 | 0.0218971 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0218705 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0214141 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0212918 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.0211957 |
| GTDC1 | glycosyltransferase-like domain containing 1 | 0.0207781 |
| MED13L | mediator complex subunit 13-like | 0.0206721 |
| STRIP2 | striatin interacting protein 2 | 0.0205175 |
| USP47 | ubiquitin specific peptidase 47 | 0.020341 |
| TUT7 | terminal uridylyl transferase 7 | 0.020168 |
| RAB31 | RAB31, member RAS oncogene family | 0.0196861 |
| PMM2 | phosphomannomutase 2 | 0.0196285 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0194433 |
| MXD1 | MAX dimerization protein 1 | 0.0193082 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0191908 |
| RAI14 | retinoic acid induced 14 | 0.019044 |
| FHL2 | four and a half LIM domains 2 | 0.0189715 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0189289 |
| ABHD3 | abhydrolase domain containing 3 | 0.0186227 |
| AHR | aryl hydrocarbon receptor | 0.0182951 |
| RIOK3 | RIO kinase 3 | 0.0180756 |
| XYLT1 | xylosyltransferase I | 0.0180714 |
| MYO9B | myosin IXB | 0.0176504 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0173661 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0173598 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0170146 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0167109 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.016677 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.016597 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0164502 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0162634 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0162315 |
| EXOC6B | exocyst complex component 6B | 0.016161 |
| DSC3 | desmocollin 3 | 0.0161522 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.192558 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.128323 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.110162 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0960892 |
| PTMA | prothymosin, alpha | -0.0936969 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0723871 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0707921 |
| NPSR1 | neuropeptide S receptor 1 | -0.0663158 |
| VCAN | versican | -0.0582253 |
| FLNB | filamin B, beta | -0.0544977 |
| VIM | vimentin | -0.0540962 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0531006 |
| EZR | ezrin | -0.0495179 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0492908 |
| S100A10 | S100 calcium binding protein A10 | -0.0488502 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0487042 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0484246 |
| MYOF | myoferlin | -0.0454127 |
| GOLGA4 | golgin A4 | -0.0453918 |
| ITGA6 | integrin, alpha 6 | -0.0445717 |
| TPM4 | tropomyosin 4 | -0.0439165 |
| VCL | vinculin | -0.0438771 |
| ARF4 | ADP-ribosylation factor 4 | -0.0426328 |
| FOSL1 | FOS-like antigen 1 | -0.0415259 |
| PGK1 | phosphoglycerate kinase 1 | -0.0403159 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0401637 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0397783 |
| S100A4 | S100 calcium binding protein A4 | -0.0393168 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0393056 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0392105 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0389323 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0385422 |
| RRBP1 | ribosome binding protein 1 | -0.0381113 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0377476 |
| TRRAP | transformation/transcription domain-associated protein | -0.0376178 |
| RPL35A | ribosomal protein L35a | -0.0370206 |
| GNAS | GNAS complex locus | -0.0353105 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0351828 |
| KRT8 | keratin 8, type II | -0.0345508 |
| PRELID2 | PRELI domain containing 2 | -0.0342713 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0333882 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0333267 |
| CD2AP | CD2-associated protein | -0.0332059 |
| RPS21 | ribosomal protein S21 | -0.0330207 |
| MUC17 | mucin 17, cell surface associated | -0.0328322 |
| COG5 | component of oligomeric golgi complex 5 | -0.0327087 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0325036 |
| RTN4 | reticulon 4 | -0.0322714 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.031971 |
| ACTN4 | actinin, alpha 4 | -0.0319317 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0319292 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0315886 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0315076 |
| B2M | beta-2-microglobulin | -0.0306266 |
| PERP | PERP, TP53 apoptosis effector | -0.0305545 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0304792 |
| LAMA4 | laminin, alpha 4 | -0.0301496 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0299793 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0297847 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0297236 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0295835 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0291306 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0283781 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0282009 |
| KRT19 | keratin 19, type I | -0.0280468 |
| LDHA | lactate dehydrogenase A | -0.0280352 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.027981 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0278628 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0277957 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.027563 |
| ANXA2 | annexin A2 | -0.0275339 |
| EGR1 | early growth response 1 | -0.0274401 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0273926 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0273485 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0271964 |
| POTEF | POTE ankyrin domain family, member F | -0.0270671 |
| PKM | pyruvate kinase, muscle | -0.0269912 |
| RPLP2 | ribosomal protein, large, P2 | -0.0266552 |
| RPL8 | ribosomal protein L8 | -0.0265861 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0264165 |
| ITGB4 | integrin, beta 4 | -0.0263775 |
| TXNIP | thioredoxin interacting protein | -0.0263546 |
| ANXA11 | annexin A11 | -0.0262421 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0257609 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0256641 |
| KRT18 | keratin 18, type I | -0.0254061 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0251493 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0251001 |
| RPL23 | ribosomal protein L23 | -0.0249397 |
| HMGA1 | high mobility group AT-hook 1 | -0.0248985 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0248586 |
| CALU | calumenin | -0.0247107 |
| BCL2L1 | BCL2-like 1 | -0.0246363 |
| TAOK3 | TAO kinase 3 | -0.0246261 |
| SP100 | SP100 nuclear antigen | -0.024404 |
| MTDH | metadherin | -0.0243339 |
| FBXO11 | F-box protein 11 | -0.0242176 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0238175 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0237841 |
| RBM25 | RNA binding motif protein 25 | -0.0236381 |
