| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VMP1 | vacuole membrane protein 1 | 0.106083 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0981189 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0891061 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0814431 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0766688 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0766257 |
| MT2A | metallothionein 2A | 0.0743882 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0729465 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0728802 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0721705 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0693059 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0670449 |
| NDRG1 | N-myc downstream regulated 1 | 0.0640971 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0596325 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0582879 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0582622 |
| SP100 | SP100 nuclear antigen | 0.05728 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0572021 |
| MSI2 | musashi RNA-binding protein 2 | 0.0572015 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0556082 |
| ATXN1 | ataxin 1 | 0.0524663 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.052101 |
| YAP1 | Yes-associated protein 1 | 0.0517901 |
| CLTC | clathrin, heavy chain (Hc) | 0.050799 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0505434 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0497651 |
| MAP7 | microtubule-associated protein 7 | 0.0496199 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0488155 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0483388 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0471939 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0470513 |
| RGS6 | regulator of G-protein signaling 6 | 0.0468901 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0459838 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0449445 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0442461 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0440835 |
| SMYD3 | SET and MYND domain containing 3 | 0.0437515 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0432379 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0429068 |
| VEGFA | vascular endothelial growth factor A | 0.0428147 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0417484 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0417386 |
| SBF2 | SET binding factor 2 | 0.0410151 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0409091 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0396076 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0396021 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0392564 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0389836 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0381516 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0376837 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0372354 |
| SMAD3 | SMAD family member 3 | 0.0358501 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0355657 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0348803 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0346342 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0345505 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0343565 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0340039 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0339166 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0337735 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0336212 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0335455 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0335074 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0333322 |
| PLSCR2 | phospholipid scramblase 2 | 0.0330328 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0326592 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0324636 |
| PLSCR1 | phospholipid scramblase 1 | 0.0323157 |
| FNIP1 | folliculin interacting protein 1 | 0.0322528 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0321444 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0319214 |
| ADAR | adenosine deaminase, RNA-specific | 0.0316395 |
| EXPH5 | exophilin 5 | 0.0314621 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0312882 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0311561 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.030841 |
| RASA2 | RAS p21 protein activator 2 | 0.030649 |
| INSR | insulin receptor | 0.0305961 |
| INTS6 | integrator complex subunit 6 | 0.0303256 |
| APP | amyloid beta (A4) precursor protein | 0.0297072 |
| SGMS1 | sphingomyelin synthase 1 | 0.0296047 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0294179 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0291878 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0289837 |
| BBX | bobby sox homolog (Drosophila) | 0.0287405 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0286115 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0285958 |
| FBXO32 | F-box protein 32 | 0.0284419 |
| SYTL2 | synaptotagmin-like 2 | 0.0284196 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0282733 |
| MCU | mitochondrial calcium uniporter | 0.0280785 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0280192 |
| EGFR | epidermal growth factor receptor | 0.0278464 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0277891 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0277372 |
| FAM219A | family with sequence similarity 219, member A | 0.0275956 |
| CDK13 | cyclin-dependent kinase 13 | 0.0269031 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0268319 |
| NEBL | nebulette | 0.0267924 |
| MYO1D | myosin ID | 0.0265007 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.159635 |
| ACACA | acetyl-CoA carboxylase alpha | -0.156778 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.130916 |
| ASPH | aspartate beta-hydroxylase | -0.117658 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.112108 |
| PTMA | prothymosin, alpha | -0.101728 |
| LASP1 | LIM and SH3 protein 1 | -0.0843556 |
| CCND1 | cyclin D1 | -0.0808399 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0794867 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0756378 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0714657 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0706539 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0673252 |
| RPL23 | ribosomal protein L23 | -0.0657441 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0635811 |
| TENM2 | teneurin transmembrane protein 2 | -0.0633675 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0606125 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0603678 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0596933 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.0528203 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0511245 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0482688 |
| KIAA1217 | KIAA1217 | -0.0471681 |
| FADS2 | fatty acid desaturase 2 | -0.0471631 |
| YPEL2 | yippee-like 2 (Drosophila) | -0.0464179 |
| TMEM123 | transmembrane protein 123 | -0.045282 |
| AHNAK | AHNAK nucleoprotein | -0.0442244 |
| DUSP4 | dual specificity phosphatase 4 | -0.0441066 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0428935 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0413863 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0406328 |
| ENAH | enabled homolog (Drosophila) | -0.0397311 |
| ACTN4 | actinin, alpha 4 | -0.0395119 |
| FDPS | farnesyl diphosphate synthase | -0.0382092 |
| ANXA2 | annexin A2 | -0.0376057 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0359886 |
| ZNF652 | zinc finger protein 652 | -0.0355835 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0354555 |
| PGK1 | phosphoglycerate kinase 1 | -0.0353331 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0349368 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0348904 |
| FASN | fatty acid synthase | -0.034713 |
| IER3 | immediate early response 3 | -0.0345652 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0340933 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0339131 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0339006 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0336707 |
| TMC5 | transmembrane channel-like 5 | -0.0330908 |
| TMSB4X | thymosin beta 4, X-linked | -0.0323081 |
| TMSB10 | thymosin beta 10 | -0.0320298 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0319265 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.031748 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0314711 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0313942 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0311785 |
| ZNF217 | zinc finger protein 217 | -0.0303599 |
| TTC6 | tetratricopeptide repeat domain 6 | -0.0296515 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0289952 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0286981 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0285927 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0285883 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0284401 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0284147 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | -0.0278199 |
| SHROOM3 | shroom family member 3 | -0.0275282 |
| VIM | vimentin | -0.0272415 |
| KRT18 | keratin 18, type I | -0.0271619 |
| GNAS | GNAS complex locus | -0.0271069 |
| DSTN | destrin (actin depolymerizing factor) | -0.0270037 |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | -0.0269978 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.026985 |
| NFIA | nuclear factor I/A | -0.0269116 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0266427 |
| AUTS2 | autism susceptibility candidate 2 | -0.0262541 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0257137 |
| KLF6 | Kruppel-like factor 6 | -0.0256852 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0255609 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0254541 |
| TPM1 | tropomyosin 1 (alpha) | -0.0254352 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.025224 |
| MGLL | monoglyceride lipase | -0.0249903 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0247058 |
| HDLBP | high density lipoprotein binding protein | -0.0243844 |
| PLCB4 | phospholipase C, beta 4 | -0.0243495 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0242633 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0242231 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.024081 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0239722 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0239332 |
| TP53INP2 | tumor protein p53 inducible nuclear protein 2 | -0.0237763 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.02376 |
| RPS3 | ribosomal protein S3 | -0.0236228 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0235249 |
| MACROD2 | MACRO domain containing 2 | -0.0233086 |
| TC2N | tandem C2 domains, nuclear | -0.0228577 |
| CCNI | cyclin I | -0.0228381 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -0.022636 |
| RRBP1 | ribosome binding protein 1 | -0.0225916 |
| ANKRD30A | ankyrin repeat domain 30A | -0.0224009 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0222654 |
