| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.178456 |
| FN1 | fibronectin 1 | 0.143843 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.142669 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.113685 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.111456 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0960177 |
| ACTG1 | actin gamma 1 | 0.0927806 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0845511 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0835902 |
| NAV1 | neuron navigator 1 | 0.0815989 |
| GPC6 | glypican 6 | 0.080804 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.07796 |
| ENO1 | enolase 1, (alpha) | 0.0767007 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0721989 |
| CD109 | CD109 molecule | 0.0642087 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0640097 |
| NDRG1 | N-myc downstream regulated 1 | 0.0635779 |
| CUX1 | cut-like homeobox 1 | 0.0633288 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0618465 |
| EGR1 | early growth response 1 | 0.0614649 |
| LRRC23 | leucine rich repeat containing 23 | 0.0614057 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0603971 |
| SFTPA2 | surfactant protein A2 | 0.0579322 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0567211 |
| MCL1 | myeloid cell leukemia 1 | 0.0546694 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0539747 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0531946 |
| DST | dystonin | 0.0527323 |
| INTS6 | integrator complex subunit 6 | 0.0510475 |
| NAV3 | neuron navigator 3 | 0.0485869 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0484585 |
| STXBP1 | syntaxin binding protein 1 | 0.0480939 |
| EMP1 | epithelial membrane protein 1 | 0.046961 |
| GDF15 | growth differentiation factor 15 | 0.0467508 |
| CTTNBP2 | cortactin binding protein 2 | 0.0465492 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0465424 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.046475 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0457968 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0456145 |
| LMNA | lamin A/C | 0.0441624 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0436029 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0429454 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0425112 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0419866 |
| S100A6 | S100 calcium binding protein A6 | 0.0416486 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0415433 |
| EHBP1 | EH domain binding protein 1 | 0.04119 |
| MYO1E | myosin IE | 0.0404315 |
| SEPTIN9 | septin 9 | 0.040157 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0393658 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0390566 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0390422 |
| AHNAK | AHNAK nucleoprotein | 0.0384485 |
| NAV2 | neuron navigator 2 | 0.0383062 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0381318 |
| ADM | adrenomedullin | 0.0377746 |
| CD44 | CD44 molecule (Indian blood group) | 0.0373582 |
| TLE4 | transducin-like enhancer of split 4 | 0.0373554 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0365359 |
| JUN | jun proto-oncogene | 0.0354076 |
| SQSTM1 | sequestosome 1 | 0.0353643 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0352841 |
| HLA-B | major histocompatibility complex, class I, B | 0.035192 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0351553 |
| FUS | FUS RNA binding protein | 0.0349988 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0343005 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0341278 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.03387 |
| PLIN2 | perilipin 2 | 0.0335339 |
| GOLGB1 | golgin B1 | 0.0332684 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.03277 |
| DIAPH2 | diaphanous-related formin 2 | 0.0326745 |
| CALU | calumenin | 0.0325876 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0321987 |
| PARVB | parvin, beta | 0.0313941 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0310495 |
| LDHA | lactate dehydrogenase A | 0.0309589 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0299368 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0299151 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.0298289 |
| ORAI2 | ORAI calcium release-activated calcium modulator 2 | 0.0297628 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.02971 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0295548 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0291735 |
| HLA-E | major histocompatibility complex, class I, E | 0.0291324 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0291288 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0285479 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0284098 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0282162 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0278958 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.0278144 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0278118 |
| IRS2 | insulin receptor substrate 2 | 0.0274795 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.027196 |
| SHISA5 | shisa family member 5 | 0.0270849 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0270662 |
| VGF | VGF nerve growth factor inducible | 0.0270417 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0266604 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.026537 |
| FGF13 | fibroblast growth factor 13 | 0.0264551 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.149498 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.112343 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0959744 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0933928 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0830795 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0817702 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0799606 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0789735 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0754167 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0744901 |
| TNNC1 | troponin C type 1 (slow) | -0.0655779 |
| PI15 | peptidase inhibitor 15 | -0.06385 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.063467 |
| ASPH | aspartate beta-hydroxylase | -0.0616106 |
| RTN4 | reticulon 4 | -0.0565507 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0564391 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0562502 |
| AHR | aryl hydrocarbon receptor | -0.0544584 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0530411 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0523487 |
| CDC73 | cell division cycle 73 | -0.0508661 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0504414 |
| SRPK2 | SRSF protein kinase 2 | -0.0500136 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0483796 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.048171 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0471307 |
| FMN1 | formin 1 | -0.0468624 |
| NUP58 | nucleoporin 58 | -0.0458074 |
| FNDC3B | fibronectin type III domain containing 3B | -0.045269 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0452409 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0440747 |
| PCDH7 | protocadherin 7 | -0.0427491 |
| OXR1 | oxidation resistance 1 | -0.0426414 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.042468 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0421395 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0414561 |
| TMEM178B | transmembrane protein 178B | -0.0393814 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0388642 |
| RBM33 | RNA binding motif protein 33 | -0.0378699 |
| FOXJ3 | forkhead box J3 | -0.0372393 |
| RNF145 | ring finger protein 145 | -0.0367513 |
| CALD1 | caldesmon 1 | -0.036616 |
| RFX7 | regulatory factor X, 7 | -0.0363851 |
| VMP1 | vacuole membrane protein 1 | -0.0357196 |
| XPO1 | exportin 1 | -0.0356226 |
| OGA | O-GlcNAcase | -0.0345115 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0344305 |
| MACROD2 | MACRO domain containing 2 | -0.0342431 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0341719 |
| PRELID2 | PRELI domain containing 2 | -0.0331956 |
| NEK7 | NIMA-related kinase 7 | -0.0327112 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0325712 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0315769 |
| PGK1 | phosphoglycerate kinase 1 | -0.0312465 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0298678 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.029428 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0293679 |
| GSN | gelsolin | -0.0293135 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0293 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0290241 |
| PHF21A | PHD finger protein 21A | -0.0289796 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0288167 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0279674 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0278094 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0274478 |
| EPHA3 | EPH receptor A3 | -0.027347 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.0272792 |
| SNX1 | sorting nexin 1 | -0.0268633 |
| ZNF292 | zinc finger protein 292 | -0.0266857 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0265615 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0263731 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0262064 |
| KLHDC10 | kelch domain containing 10 | -0.0261532 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0259802 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0259032 |
| RCAN1 | regulator of calcineurin 1 | -0.0256259 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.025557 |
| MTPN | myotrophin | -0.0252743 |
| FAM91A1 | family with sequence similarity 91, member A1 | -0.025018 |
| TFG | TRK-fused gene | -0.0250123 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0249944 |
| SNX13 | sorting nexin 13 | -0.0249447 |
| MED15 | mediator complex subunit 15 | -0.024846 |
| CEP85L | centrosomal protein 85kDa-like | -0.0245609 |
| MRTFA | myocardin related transcription factor A | -0.0245569 |
| SRI | sorcin | -0.0242926 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | -0.0237597 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0236958 |
| CAPRIN1 | cell cycle associated protein 1 | -0.0236151 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0235951 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0234724 |
| WDR43 | WD repeat domain 43 | -0.0230539 |
| VGLL4 | vestigial-like family member 4 | -0.022933 |
| LRAT | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | -0.0229285 |
| HELZ | helicase with zinc finger | -0.022862 |
| NBAS | neuroblastoma amplified sequence | -0.0228505 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0228451 |
| COG5 | component of oligomeric golgi complex 5 | -0.0228109 |
| WDR45B | WD repeat domain 45B | -0.0226493 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0226035 |
