AZD-8055_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.183158
NRG1 neuregulin 1 0.153757
FMN1 formin 1 0.152589
VCL vinculin 0.113165
PTPRD protein tyrosine phosphatase, receptor type, D 0.103943
EXT1 exostosin glycosyltransferase 1 0.0806183
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0783832
NALF1 NALCN channel auxiliary factor 1 0.0761356
SYT1 synaptotagmin I 0.0734571
ZBTB20 zinc finger and BTB domain containing 20 0.0732892
TLE4 transducin-like enhancer of split 4 0.0730961
ANTXR1 anthrax toxin receptor 1 0.0723848
MEIS2 Meis homeobox 2 0.0702417
AKAP12 A kinase (PRKA) anchor protein 12 0.068938
TPST1 tyrosylprotein sulfotransferase 1 0.0685388
KLHL13 kelch-like family member 13 0.0677757
BPTF bromodomain PHD finger transcription factor 0.0588471
VMP1 vacuole membrane protein 1 0.058833
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0545825
BCAS3 breast carcinoma amplified sequence 3 0.0529828
CPED1 cadherin-like and PC-esterase domain containing 1 0.0522983
SLIT2 slit homolog 2 (Drosophila) 0.0504465
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0496462
PLAT plasminogen activator, tissue 0.048621
SOS1 son of sevenless homolog 1 (Drosophila) 0.0473765
NPAS2 neuronal PAS domain protein 2 0.0466974
ZSWIM6 zinc finger, SWIM-type containing 6 0.0451276
FNDC3A fibronectin type III domain containing 3A 0.0445405
SLITRK6 SLIT and NTRK-like family, member 6 0.044399
COL4A5 collagen, type IV, alpha 5 0.0439042
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0438949
THSD4 thrombospondin, type I, domain containing 4 0.0415983
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0410614
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0405955
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0392089
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.038647
FRMD4A FERM domain containing 4A 0.0384218
DST dystonin 0.0383132
PLPP1 phospholipid phosphatase 1 0.0382752
GLCCI1 glucocorticoid induced 1 0.0380753
RPTOR regulatory associated protein of MTOR, complex 1 0.037883
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0374636
PTPRE protein tyrosine phosphatase, receptor type, E 0.0366993
DNAH14 dynein, axonemal, heavy chain 14 0.0360932
FNDC3B fibronectin type III domain containing 3B 0.0349018
LINGO2 leucine rich repeat and Ig domain containing 2 0.034786
NREP neuronal regeneration related protein 0.0347676
PRKCA protein kinase C, alpha 0.034521
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0344846
SIK2 salt-inducible kinase 2 0.0342539
CADM2 cell adhesion molecule 2 0.0332576
MAPK10 mitogen-activated protein kinase 10 0.0325474
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0323244
ADGRB3 adhesion G protein-coupled receptor B3 0.0322268
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0320856
PTPRK protein tyrosine phosphatase, receptor type, K 0.03195
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0317799
TRIO trio Rho guanine nucleotide exchange factor 0.0312011
SMYD3 SET and MYND domain containing 3 0.0311505
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0303985
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0303051
TENM4 teneurin transmembrane protein 4 0.0299174
STK38L serine/threonine kinase 38 like 0.0298815
AUTS2 autism susceptibility candidate 2 0.029795
BICD1 bicaudal D homolog 1 (Drosophila) 0.029784
RNF213 ring finger protein 213 0.02837
DPH6 diphthamine biosynthesis 6 0.0281525
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0279385
FHIT fragile histidine triad 0.0278302
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0275747
DGKH diacylglycerol kinase, eta 0.0275615
FAM107B family with sequence similarity 107, member B 0.0274566
NBEA neurobeachin 0.0272892
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0270977
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0269892
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0267446
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0264556
TCF12 transcription factor 12 0.0263773
TAS2R14 taste receptor, type 2, member 14 0.0262473
RAD51B RAD51 paralog B 0.0259654
PBX1 pre-B-cell leukemia homeobox 1 0.0254714
AEBP2 AE binding protein 2 0.0249297
HSPA8 heat shock 70kDa protein 8 0.0248815
PDE10A phosphodiesterase 10A 0.0248796
GREM2 gremlin 2, DAN family BMP antagonist 0.024794
COL4A2 collagen, type IV, alpha 2 0.0247825
N4BP2L2 NEDD4 binding protein 2-like 2 0.0244137
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0243786
PCDH17 protocadherin 17 0.0239328
CEMIP cell migration inducing protein, hyaluronan binding 0.0237362
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0237238
ATRNL1 attractin-like 1 0.0236536
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0234396
SDK1 sidekick cell adhesion molecule 1 0.023437
SDCCAG8 serologically defined colon cancer antigen 8 0.0230688
CLTC clathrin, heavy chain (Hc) 0.0230232
RPS2 ribosomal protein S2 0.0228341
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0227349
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0226557
GPC5 glypican 5 0.0225365

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.0875275
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0757967
PTMA prothymosin, alpha -0.0688711
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0641374
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0464036
IGF2 insulin-like growth factor 2 -0.0430678
TMSB10 thymosin beta 10 -0.036227
WDR45B WD repeat domain 45B -0.0356698
NPEPPS aminopeptidase puromycin sensitive -0.0347105
ANXA2 annexin A2 -0.0344752
COL1A1 collagen, type I, alpha 1 -0.0339032
LMNA lamin A/C -0.0333707
KDM3A lysine (K)-specific demethylase 3A -0.031838
HELZ helicase with zinc finger -0.0317374
S100A6 S100 calcium binding protein A6 -0.0294635
FTL ferritin, light polypeptide -0.0294406
RPLP1 ribosomal protein, large, P1 -0.0271098
RPL35A ribosomal protein L35a -0.0265416
HMGB2 high mobility group box 2 -0.0265169
OGA O-GlcNAcase -0.0264763
SPAG9 sperm associated antigen 9 -0.0255532
WAC WW domain containing adaptor with coiled-coil -0.025317
USP3 ubiquitin specific peptidase 3 -0.0249293
PTK2 protein tyrosine kinase 2 -0.0242393
RPL23 ribosomal protein L23 -0.0240439
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0239361
KMT2E lysine (K)-specific methyltransferase 2E -0.0227517
GARS1 glycyl-tRNA synthetase 1 -0.0215345
CCND1 cyclin D1 -0.0213472
IER3 immediate early response 3 -0.0211768
FOXK2 forkhead box K2 -0.020507
CDC27 cell division cycle 27 -0.020474
RTN4 reticulon 4 -0.0203999
RIOK3 RIO kinase 3 -0.02031
WSB1 WD repeat and SOCS box containing 1 -0.0202033
MARCHF6 membrane associated ring-CH-type finger 6 -0.0193116
DSCAM Down syndrome cell adhesion molecule -0.0190067
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0188608
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0187844
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0186098
QKI QKI, KH domain containing, RNA binding -0.0183137
HMGA1 high mobility group AT-hook 1 -0.0182619
DTNA dystrobrevin, alpha -0.018259
RPS6 ribosomal protein S6 -0.0180999
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0178293
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0173959
KPNB1 karyopherin (importin) beta 1 -0.0173911
RPS19 ribosomal protein S19 -0.0171769
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.01716
RAB6A RAB6A, member RAS oncogene family -0.01698
RPL19 ribosomal protein L19 -0.0166957
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0166108
DDIT4 DNA-damage-inducible transcript 4 -0.0165815
LCORL ligand dependent nuclear receptor corepressor-like -0.0165781
UBE2O ubiquitin-conjugating enzyme E2O -0.0165657
RAD21 RAD21 homolog (S. pombe) -0.0164954
RPS29 ribosomal protein S29 -0.0161797
ATXN2L ataxin 2-like -0.0161505
RPS27A ribosomal protein S27a -0.0160507
RLF rearranged L-myc fusion -0.0159666
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0158301
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0157784
CALU calumenin -0.0157396
ARF1 ADP-ribosylation factor 1 -0.0157363
RPL34 ribosomal protein L34 -0.0153775
MYOF myoferlin -0.0152373
HILPDA hypoxia inducible lipid droplet-associated -0.01523
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0151082
USP15 ubiquitin specific peptidase 15 -0.01498
PKM pyruvate kinase, muscle -0.0148923
RPL36 ribosomal protein L36 -0.0146826
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0146393
SSBP2 single-stranded DNA binding protein 2 -0.0146386
TLK2 tousled-like kinase 2 -0.0145638
TUBB tubulin, beta class I -0.0145436
NAP1L4 nucleosome assembly protein 1-like 4 -0.0144411
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0143599
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0143229
GOLGA4 golgin A4 -0.0140422
S100A10 S100 calcium binding protein A10 -0.0140079
LPIN1 lipin 1 -0.0139529
SEPTIN7 septin 7 -0.013858
UBE2K ubiquitin-conjugating enzyme E2K -0.0138213
NDRG1 N-myc downstream regulated 1 -0.0136813
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0136757
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0136502
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0136236
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0135486
RPS24 ribosomal protein S24 -0.0135361
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0134654
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0132543
WDFY2 WD repeat and FYVE domain containing 2 -0.0131983
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0131332
ZNF292 zinc finger protein 292 -0.0130405
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0129853
TXNRD1 thioredoxin reductase 1 -0.0129393
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0129296
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -0.0127141
XPO1 exportin 1 -0.012699
IARS1 isoleucyl-tRNA synthetase 1 -0.0126827