AZD-8055_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.154862
PHF3 PHD finger protein 3 0.101415
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0944735
SMAD3 SMAD family member 3 0.0943261
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0872018
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0793139
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0789371
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.073614
BTBD9 BTB (POZ) domain containing 9 0.0718319
MBNL2 muscleblind-like splicing regulator 2 0.0674745
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0615883
MAP7 microtubule-associated protein 7 0.0603661
EXT1 exostosin glycosyltransferase 1 0.0596509
FNDC3B fibronectin type III domain containing 3B 0.0593039
GOLGB1 golgin B1 0.0591966
DSCAM Down syndrome cell adhesion molecule 0.0590562
AKAP13 A kinase (PRKA) anchor protein 13 0.0564087
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0555827
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0554304
INTS6 integrator complex subunit 6 0.0541697
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0538716
ZBTB20 zinc finger and BTB domain containing 20 0.0494961
CANX calnexin 0.0491587
TMC5 transmembrane channel-like 5 0.0475707
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0475682
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0472403
AHI1 Abelson helper integration site 1 0.0434316
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0433789
YAP1 Yes-associated protein 1 0.043023
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0410814
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0397683
GK glycerol kinase 0.0392958
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0373524
ATXN1 ataxin 1 0.0366112
TSC22D1 TSC22 domain family, member 1 0.0355619
SAMD4A sterile alpha motif domain containing 4A 0.0352451
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.034522
PLSCR2 phospholipid scramblase 2 0.0337582
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0330667
N4BP2L2 NEDD4 binding protein 2-like 2 0.0327056
IFNGR1 interferon gamma receptor 1 0.0323824
PDZD8 PDZ domain containing 8 0.0321383
TM9SF2 transmembrane 9 superfamily member 2 0.0319188
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0315707
PIBF1 progesterone immunomodulatory binding factor 1 0.0311945
FNIP1 folliculin interacting protein 1 0.0310709
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0309179
AFF1 AF4/FMR2 family, member 1 0.0298812
TMEM65 transmembrane protein 65 0.0295087
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.028602
MCTP1 multiple C2 domains, transmembrane 1 0.0285079
ASPH aspartate beta-hydroxylase 0.0284055
DPP4 dipeptidyl-peptidase 4 0.0282583
IQGAP1 IQ motif containing GTPase activating protein 1 0.0279301
TRIO trio Rho guanine nucleotide exchange factor 0.0277552
KLF5 Kruppel-like factor 5 (intestinal) 0.0276638
ANKHD1 ankyrin repeat and KH domain containing 1 0.0271917
RAD51B RAD51 paralog B 0.0270759
AFAP1L2 actin filament associated protein 1-like 2 0.0268134
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0265757
EFNB2 ephrin-B2 0.0259901
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0259128
GCLC glutamate-cysteine ligase, catalytic subunit 0.0250914
DST dystonin 0.0246697
ATF6 activating transcription factor 6 0.0245954
SEC24D SEC24 family member D 0.0244253
FAT1 FAT atypical cadherin 1 0.0243194
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0242233
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.023981
MCU mitochondrial calcium uniporter 0.0239068
KYNU kynureninase 0.0238783
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0237826
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.02331
BICRAL BICRA like chromatin remodeling complex associated protein 0.022992
DUSP16 dual specificity phosphatase 16 0.022784
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0226585
APP amyloid beta (A4) precursor protein 0.0226574
PARD3 par-3 family cell polarity regulator 0.0223585
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0220505
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0220071
MYO1E myosin IE 0.0219553
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0217645
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0215776
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0215636
HSPA8 heat shock 70kDa protein 8 0.02139
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.021333
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 0.0212895
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0212474
EXOC4 exocyst complex component 4 0.0212018
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0210801
FMN1 formin 1 0.0210596
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0208106
EHBP1 EH domain binding protein 1 0.0207935
SMYD3 SET and MYND domain containing 3 0.0206397
MLPH melanophilin 0.0206342
JAK1 Janus kinase 1 0.019826
CTSB cathepsin B 0.0196887
MAML2 mastermind-like 2 (Drosophila) 0.0196672
STAG2 stromal antigen 2 0.0196184
UTRN utrophin 0.0195087

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.17519
PTMA prothymosin, alpha -0.111385
EPSTI1 epithelial stromal interaction 1 (breast) -0.104216
IFI6 interferon, alpha-inducible protein 6 -0.092159
LYZ lysozyme -0.0887923
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0883102
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0839339
MX2 MX dynamin-like GTPase 2 -0.0833928
EGR1 early growth response 1 -0.0831356
IFI27 interferon, alpha-inducible protein 27 -0.0825789
HLA-B major histocompatibility complex, class I, B -0.0777943
RNF213 ring finger protein 213 -0.0745796
C6ORF132 chromosome 6 open reading frame 132 -0.0743702
MX1 MX dynamin-like GTPase 1 -0.0728676
ARHGAP26 Rho GTPase activating protein 26 -0.067078
NPSR1 neuropeptide S receptor 1 -0.0580623
TMSB10 thymosin beta 10 -0.0579468
RIGI RNA sensor RIG-I -0.0568655
LOC102724023 ES1 protein homolog, mitochondrial -0.0537597
AREG amphiregulin -0.0521051
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0516413
FTL ferritin, light polypeptide -0.0515214
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0511993
TPT1 tumor protein, translationally-controlled 1 -0.0488004
RPL35A ribosomal protein L35a -0.0478502
TXNIP thioredoxin interacting protein -0.0460668
KRT19 keratin 19, type I -0.0451791
MACC1 metastasis associated in colon cancer 1 -0.0449977
RSAD2 radical S-adenosyl methionine domain containing 2 -0.043702
S100A6 S100 calcium binding protein A6 -0.0410767
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0408681
PKM pyruvate kinase, muscle -0.0404467
ERBIN erbb2 interacting protein -0.0402438
SP100 SP100 nuclear antigen -0.0390201
PMP22 peripheral myelin protein 22 -0.0374255
ITGA6 integrin, alpha 6 -0.036868
HLA-A major histocompatibility complex, class I, A -0.036615
HLA-C major histocompatibility complex, class I, C -0.0364292
RAB7A RAB7A, member RAS oncogene family -0.036232
LIMA1 LIM domain and actin binding 1 -0.0360969
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0358888
LCN2 lipocalin 2 -0.0346631
IFIH1 interferon induced with helicase C domain 1 -0.0343211
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0341777
MT2A metallothionein 2A -0.033358
ZFP36L1 ZFP36 ring finger protein-like 1 -0.033248
TM4SF19 transmembrane 4 L six family member 19 -0.0316917
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0304487
PGK1 phosphoglycerate kinase 1 -0.0302345
CLDN4 claudin 4 -0.0299888
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0298035
RABGAP1L RAB GTPase activating protein 1-like -0.0297111
GMDS GDP-mannose 4,6-dehydratase -0.0295798
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0294823
CST3 cystatin C -0.0293102
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0288428
CTSD cathepsin D -0.0287071
ISG15 ISG15 ubiquitin-like modifier -0.028637
OASL 2'-5'-oligoadenylate synthetase-like -0.0283093
ANXA4 annexin A4 -0.0279706
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0278369
SAMHD1 SAM domain and HD domain 1 -0.0269065
LY6E lymphocyte antigen 6 complex, locus E -0.0268405
IFITM3 interferon induced transmembrane protein 3 -0.0268345
ACTG1 actin gamma 1 -0.0266491
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0262624
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0261897
JUN jun proto-oncogene -0.0260943
POTEF POTE ankyrin domain family, member F -0.0260891
VIM vimentin -0.0260777
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.026042
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.026035
RPL23 ribosomal protein L23 -0.0258395
RPS24 ribosomal protein S24 -0.0257401
DIAPH3 diaphanous-related formin 3 -0.0254089
RPLP1 ribosomal protein, large, P1 -0.02512
RPS19 ribosomal protein S19 -0.0251092
RPS6 ribosomal protein S6 -0.0250032
VDAC1 voltage-dependent anion channel 1 -0.0247966
NDRG1 N-myc downstream regulated 1 -0.0242325
RBM25 RNA binding motif protein 25 -0.0239732
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0238714
TNS4 tensin 4 -0.0237937
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0237647
PLIN2 perilipin 2 -0.0233541
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0233134
SMC4 structural maintenance of chromosomes 4 -0.0229633
GNAS GNAS complex locus -0.0229252
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0229167
S100A11 S100 calcium binding protein A11 -0.0227643
EFHD2 EF-hand domain family, member D2 -0.0225149
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0224797
HMGB1 high mobility group box 1 -0.0223235
APOL1 apolipoprotein L, 1 -0.0222434
RPL37A ribosomal protein L37a -0.0221395
TFF3 trefoil factor 3 (intestinal) -0.0220618
ENO1 enolase 1, (alpha) -0.0218887
TPI1 triosephosphate isomerase 1 -0.0218563
MDK midkine (neurite growth-promoting factor 2) -0.02166
S100A9 S100 calcium binding protein A9 -0.0216548