AZD-8055_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.122552
ASPH aspartate beta-hydroxylase 0.110548
STC1 stanniocalcin 1 0.0937716
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0853921
NALF1 NALCN channel auxiliary factor 1 0.0817022
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0758158
AKAP12 A kinase (PRKA) anchor protein 12 0.070507
FNDC3B fibronectin type III domain containing 3B 0.0704412
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.065894
HDAC9 histone deacetylase 9 0.0639007
TRIO trio Rho guanine nucleotide exchange factor 0.0632992
FAM13A family with sequence similarity 13, member A 0.0631353
BACE2 beta-site APP-cleaving enzyme 2 0.0583244
TTC3 tetratricopeptide repeat domain 3 0.0579997
CEMIP cell migration inducing protein, hyaluronan binding 0.0578456
NDRG1 N-myc downstream regulated 1 0.0561864
CD44 CD44 molecule (Indian blood group) 0.0549856
FNIP1 folliculin interacting protein 1 0.0518387
LOX lysyl oxidase 0.0505671
CANX calnexin 0.0501586
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0486448
MACF1 microtubule-actin crosslinking factor 1 0.0461872
EXT1 exostosin glycosyltransferase 1 0.0454407
ERRFI1 ERBB receptor feedback inhibitor 1 0.043774
HMGA2 high mobility group AT-hook 2 0.0433086
MON2 MON2 homolog (S. cerevisiae) 0.0422603
OSMR oncostatin M receptor 0.0394782
CALU calumenin 0.0390438
GOLGA4 golgin A4 0.038931
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0369278
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.036685
HELZ helicase with zinc finger 0.0358276
SLC39A11 solute carrier family 39, member 11 0.0352609
ANO6 anoctamin 6 0.0331244
APP amyloid beta (A4) precursor protein 0.0330896
MCTP1 multiple C2 domains, transmembrane 1 0.032013
HDLBP high density lipoprotein binding protein 0.0319399
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0318637
DST dystonin 0.0315496
COPB1 coatomer protein complex, subunit beta 1 0.0309878
JARID2 jumonji, AT rich interactive domain 2 0.030805
CLTC clathrin, heavy chain (Hc) 0.0307451
MAST4 microtubule associated serine/threonine kinase family member 4 0.0301851
SRP54 signal recognition particle 54kDa 0.0300159
PMM2 phosphomannomutase 2 0.0297874
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0296903
GOLGB1 golgin B1 0.0295074
HIPK2 homeodomain interacting protein kinase 2 0.028839
VEGFA vascular endothelial growth factor A 0.0287935
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0286494
RUNX1 runt-related transcription factor 1 0.0286489
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0285923
ZCCHC7 zinc finger, CCHC domain containing 7 0.0281181
COPA coatomer protein complex, subunit alpha 0.027819
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0277284
SUCO SUN domain containing ossification factor 0.0274056
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0272719
SEC24D SEC24 family member D 0.0271352
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0271297
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0264837
SEC31A SEC31 homolog A (S. cerevisiae) 0.026306
COG5 component of oligomeric golgi complex 5 0.0261921
USP47 ubiquitin specific peptidase 47 0.0259798
TRA2A transformer 2 alpha homolog (Drosophila) 0.0259774
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0257633
HSPA8 heat shock 70kDa protein 8 0.0257558
SON SON DNA binding protein 0.0257438
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.025479
SNX13 sorting nexin 13 0.025377
SBF2 SET binding factor 2 0.0252805
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0251618
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0249101
LAMB1 laminin, beta 1 0.0245004
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0244403
YEATS2 YEATS domain containing 2 0.0244043
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0241758
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0237703
MORF4L2 mortality factor 4 like 2 0.0236437
FAM219A family with sequence similarity 219, member A 0.0234846
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0230491
MCTP2 multiple C2 domains, transmembrane 2 0.0229558
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0229327
SCFD1 sec1 family domain containing 1 0.0227575
CLINT1 clathrin interactor 1 0.0227009
ZFAND3 zinc finger, AN1-type domain 3 0.0226111
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0224943
COG6 component of oligomeric golgi complex 6 0.0223294
AKAP9 A kinase (PRKA) anchor protein 9 0.0223282
RAB7A RAB7A, member RAS oncogene family 0.0220663
TAS2R14 taste receptor, type 2, member 14 0.0219043
ASCC3 activating signal cointegrator 1 complex subunit 3 0.021697
DTNA dystrobrevin, alpha 0.021485
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0213569
PHF3 PHD finger protein 3 0.0212714
MMP12 matrix metallopeptidase 12 0.0212282
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.021185
ZC3H11A zinc finger CCCH-type containing 11A 0.0211425
SEC23A Sec23 homolog A (S. cerevisiae) 0.0210996
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0210984
ZNF841 zinc finger protein 841 0.0210508

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.149278
IGFBP3 insulin-like growth factor binding protein 3 -0.137665
FTL ferritin, light polypeptide -0.133115
TMSB10 thymosin beta 10 -0.105326
PTMA prothymosin, alpha -0.0967995
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0710934
TPM4 tropomyosin 4 -0.0651231
RPL35A ribosomal protein L35a -0.0624753
MT2A metallothionein 2A -0.0561674
HLA-B major histocompatibility complex, class I, B -0.0549092
RPLP1 ribosomal protein, large, P1 -0.0527326
RPL37A ribosomal protein L37a -0.0511636
TPT1 tumor protein, translationally-controlled 1 -0.0506915
PDE4D phosphodiesterase 4D, cAMP-specific -0.0506538
RPS6 ribosomal protein S6 -0.0460914
RPLP2 ribosomal protein, large, P2 -0.0424048
HIP1 huntingtin interacting protein 1 -0.0411467
ACTG1 actin gamma 1 -0.0397488
HLA-A major histocompatibility complex, class I, A -0.0396726
RPS13 ribosomal protein S13 -0.0387077
RPS25 ribosomal protein S25 -0.0386666
WSB1 WD repeat and SOCS box containing 1 -0.0386318
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0382582
RPL23 ribosomal protein L23 -0.0365322
RPS27A ribosomal protein S27a -0.035788
RPL31 ribosomal protein L31 -0.035772
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0355893
NLGN1 neuroligin 1 -0.0351022
RPL28 ribosomal protein L28 -0.0346962
VCL vinculin -0.0330027
S100A10 S100 calcium binding protein A10 -0.0329126
RPL37 ribosomal protein L37 -0.031457
RPS8 ribosomal protein S8 -0.0310033
IGFBP5 insulin-like growth factor binding protein 5 -0.0297174
RNF213 ring finger protein 213 -0.0294821
CAVIN1 caveolae associated protein 1 -0.0291963
ENO2 enolase 2 (gamma, neuronal) -0.0290528
AHNAK2 AHNAK nucleoprotein 2 -0.028506
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.028258
RPL34 ribosomal protein L34 -0.0278395
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0277124
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0269034
RPS29 ribosomal protein S29 -0.0262296
RPL7A ribosomal protein L7a -0.0260379
SEPTIN9 septin 9 -0.0260115
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0258167
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0256515
VDAC1 voltage-dependent anion channel 1 -0.0254701
RPS16 ribosomal protein S16 -0.0253034
RPS12 ribosomal protein S12 -0.0252128
RPL9 ribosomal protein L9 -0.0250611
RPS23 ribosomal protein S23 -0.0245683
FN1 fibronectin 1 -0.0241749
S100A6 S100 calcium binding protein A6 -0.023885
KYNU kynureninase -0.0236996
LMNA lamin A/C -0.023137
RAB31 RAB31, member RAS oncogene family -0.0231033
RPL36 ribosomal protein L36 -0.022607
ZMYND8 zinc finger, MYND-type containing 8 -0.0224636
RPL38 ribosomal protein L38 -0.0222848
SP100 SP100 nuclear antigen -0.0219655
PKM pyruvate kinase, muscle -0.0219095
PDLIM5 PDZ and LIM domain 5 -0.021702
PSD3 pleckstrin and Sec7 domain containing 3 -0.0216649
RPL27A ribosomal protein L27a -0.0215641
RPS24 ribosomal protein S24 -0.0214413
POTEF POTE ankyrin domain family, member F -0.0213808
MKI67 marker of proliferation Ki-67 -0.0213734
EGR1 early growth response 1 -0.0213316
TGFBI transforming growth factor, beta-induced, 68kDa -0.0212164
RPL13A ribosomal protein L13a -0.0210934
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0210584
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0209533
SMC4 structural maintenance of chromosomes 4 -0.0208962
RPL11 ribosomal protein L11 -0.0208277
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0207773
RAN RAN, member RAS oncogene family -0.0206359
ANXA2 annexin A2 -0.0205481
IGF2 insulin-like growth factor 2 -0.0204445
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0202115
ACTN4 actinin, alpha 4 -0.0201284
SYT1 synaptotagmin I -0.0201272
RPS20 ribosomal protein S20 -0.0199101
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0193874
RTN4 reticulon 4 -0.0193475
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0191779
RPS17 ribosomal protein S17 -0.0190973
PLEC plectin -0.0190649
ABR active BCR-related -0.0190593
RPS5 ribosomal protein S5 -0.0190143
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0189768
LAMB3 laminin, beta 3 -0.0184032
RPS27 ribosomal protein S27 -0.0180221
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0178993
PCDH7 protocadherin 7 -0.0178746
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0178342
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0175587
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0172348
RPS14 ribosomal protein S14 -0.0172342
IFITM3 interferon induced transmembrane protein 3 -0.0171969