| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.180735 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.109252 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0889252 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0862141 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0794856 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0710536 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0670137 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.064545 |
| INTS6 | integrator complex subunit 6 | 0.0544327 |
| ENO1 | enolase 1, (alpha) | 0.0538367 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0523603 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0463682 |
| LRRC23 | leucine rich repeat containing 23 | 0.0438277 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0410828 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0404195 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0393146 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0388678 |
| ASPH | aspartate beta-hydroxylase | 0.0321066 |
| DSG2 | desmoglein 2 | 0.0317023 |
| GPC5 | glypican 5 | 0.0312481 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0301361 |
| TXNIP | thioredoxin interacting protein | 0.0292213 |
| RPS18 | ribosomal protein S18 | 0.0289851 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0285762 |
| FAM107B | family with sequence similarity 107, member B | 0.0281967 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0281315 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0278714 |
| TGFB1 | transforming growth factor, beta 1 | 0.0272306 |
| RPL3 | ribosomal protein L3 | 0.0270525 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0267689 |
| RPS2 | ribosomal protein S2 | 0.0261271 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0261258 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0259098 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0258111 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0246247 |
| TLN1 | talin 1 | 0.0238242 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.023199 |
| BRD2 | bromodomain containing 2 | 0.0229754 |
| AEBP2 | AE binding protein 2 | 0.0228334 |
| CDCP1 | CUB domain containing protein 1 | 0.0226884 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0226817 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0226733 |
| EGFR | epidermal growth factor receptor | 0.0225501 |
| ARRDC3 | arrestin domain containing 3 | 0.0225455 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0224352 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0221483 |
| RUNX1 | runt-related transcription factor 1 | 0.0218845 |
| DSPP | dentin sialophosphoprotein | 0.0217742 |
| RPL7 | ribosomal protein L7 | 0.0211878 |
| LDHA | lactate dehydrogenase A | 0.0210127 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0200763 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0200714 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0199912 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0198939 |
| AHNAK | AHNAK nucleoprotein | 0.0197236 |
| CLU | clusterin | 0.0192601 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0192323 |
| TRIM72 | tripartite motif containing 72, E3 ubiquitin protein ligase | 0.0190599 |
| EFNB2 | ephrin-B2 | 0.0188077 |
| CTBP2 | C-terminal binding protein 2 | 0.0187158 |
| SFTPA2 | surfactant protein A2 | 0.0185638 |
| ZNF395 | zinc finger protein 395 | 0.0184725 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0184389 |
| VEGFA | vascular endothelial growth factor A | 0.0184117 |
| RCC1 | regulator of chromosome condensation 1 | 0.0183673 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0176716 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.017663 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0176173 |
| SEPTIN9 | septin 9 | 0.0175888 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0175636 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0173198 |
| KRT18 | keratin 18, type I | 0.0172841 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0171004 |
| WWC1 | WW and C2 domain containing 1 | 0.0170158 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0169746 |
| ABHD5 | abhydrolase domain containing 5 | 0.0169468 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0169452 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0168194 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0167728 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0166224 |
| ADM | adrenomedullin | 0.0163968 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.0163353 |
| RPS3 | ribosomal protein S3 | 0.0162573 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0162314 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0162238 |
| KLHL29 | kelch-like family member 29 | 0.0160427 |
| TPM3 | tropomyosin 3 | 0.0159872 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0159848 |
| RPL21 | ribosomal protein L21 | 0.0159833 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0158316 |
| CMYA5 | cardiomyopathy associated 5 | 0.0158176 |
| ITGA6 | integrin, alpha 6 | 0.0155087 |
| CTTN | cortactin | 0.0151832 |
| GCH1 | GTP cyclohydrolase 1 | 0.0150438 |
| TXNDC16 | thioredoxin domain containing 16 | 0.0149588 |
| SVIL | supervillin | 0.0149557 |
| PLEC | plectin | 0.0148903 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0146845 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0146685 |
| STPG4 | sperm-tail PG-rich repeat containing 4 | 0.0146526 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.118281 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0887955 |
| RAD51B | RAD51 paralog B | -0.0821451 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0811164 |
| FAT1 | FAT atypical cadherin 1 | -0.0661286 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.065324 |
| PTMA | prothymosin, alpha | -0.0645616 |
| PRELID2 | PRELI domain containing 2 | -0.0635656 |
| MED13L | mediator complex subunit 13-like | -0.0620257 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0587205 |
| JMJD1C | jumonji domain containing 1C | -0.0586248 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0581434 |
| VCL | vinculin | -0.0546979 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.052467 |
| GOLGA4 | golgin A4 | -0.0515696 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0509816 |
| OGA | O-GlcNAcase | -0.0504149 |
| ARF4 | ADP-ribosylation factor 4 | -0.050024 |
| RBM39 | RNA binding motif protein 39 | -0.0493252 |
| NF1 | neurofibromin 1 | -0.0490689 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0476376 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0473041 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0468061 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0462085 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0460009 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0454047 |
| KIAA1217 | KIAA1217 | -0.0451411 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0449158 |
| DIAPH3 | diaphanous-related formin 3 | -0.0446058 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0439661 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0437594 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.043185 |
| TMEM41B | transmembrane protein 41B | -0.0419237 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0418852 |
| MKI67 | marker of proliferation Ki-67 | -0.0396096 |
| RBM25 | RNA binding motif protein 25 | -0.0389192 |
| TPM4 | tropomyosin 4 | -0.0385621 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0381685 |
| OLA1 | Obg-like ATPase 1 | -0.038129 |
| TPR | translocated promoter region, nuclear basket protein | -0.0377395 |
| TENM3 | teneurin transmembrane protein 3 | -0.0371989 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0364552 |
| ZNF292 | zinc finger protein 292 | -0.0363501 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0363027 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0362355 |
| ANKRD12 | ankyrin repeat domain 12 | -0.036046 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0359952 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0359453 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0358601 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0357227 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0354043 |
| THOC2 | THO complex 2 | -0.0353415 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0353219 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.034855 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0345393 |
| RBM26 | RNA binding motif protein 26 | -0.0344835 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.034106 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0340986 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0337513 |
| KRT8 | keratin 8, type II | -0.0336701 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0330584 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.03282 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0326463 |
| VMP1 | vacuole membrane protein 1 | -0.0321989 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0319995 |
| CD2AP | CD2-associated protein | -0.031822 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0317085 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0316827 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.031513 |
| ZNF654 | zinc finger protein 654 | -0.0314351 |
| SETD5 | SET domain containing 5 | -0.0311871 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0311744 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0311282 |
| SBF2 | SET binding factor 2 | -0.0306604 |
| METTL15 | methyltransferase like 15 | -0.0305326 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0305302 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0301163 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0300952 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0300459 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0298426 |
| RPLP1 | ribosomal protein, large, P1 | -0.0298262 |
| RPL35A | ribosomal protein L35a | -0.0297979 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0297177 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0296234 |
| TMEM87A | transmembrane protein 87A | -0.0294342 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0294047 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0293863 |
| ACTN4 | actinin, alpha 4 | -0.0293334 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0292452 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0292354 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.0290284 |
| SUCO | SUN domain containing ossification factor | -0.0289917 |
| NFIA | nuclear factor I/A | -0.0289255 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0289243 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0288587 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0286297 |
| WDR26 | WD repeat domain 26 | -0.0285839 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0285244 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0284723 |
| PTEN | phosphatase and tensin homolog | -0.0283971 |
