AZD-8055_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMC2 laminin, gamma 2 0.155731
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.140594
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.137198
DSG2 desmoglein 2 0.126932
PSD3 pleckstrin and Sec7 domain containing 3 0.123229
KRT7 keratin 7, type II 0.120616
LAMB3 laminin, beta 3 0.112536
AHNAK AHNAK nucleoprotein 0.110715
ASPH aspartate beta-hydroxylase 0.107973
EEF2 eukaryotic translation elongation factor 2 0.107041
APP amyloid beta (A4) precursor protein 0.0995107
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0952348
ZBTB20 zinc finger and BTB domain containing 20 0.0941451
ACTG1 actin gamma 1 0.0924367
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0914886
CD44 CD44 molecule (Indian blood group) 0.0905374
RPS2 ribosomal protein S2 0.0879755
GOLGB1 golgin B1 0.0857452
HMGA2 high mobility group AT-hook 2 0.0846189
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0842742
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0824494
ALCAM activated leukocyte cell adhesion molecule 0.0823497
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0799588
PLEC plectin 0.0785632
PATJ PATJ crumbs cell polarity complex component 0.0768494
MYH9 myosin, heavy chain 9, non-muscle 0.0767598
EIF1 eukaryotic translation initiation factor 1 0.0762416
SVIL supervillin 0.0729729
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0715162
CCND1 cyclin D1 0.069594
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0695099
ANXA1 annexin A1 0.0688611
HSPA8 heat shock 70kDa protein 8 0.0679347
ANXA2 annexin A2 0.0659123
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0657143
DSPP dentin sialophosphoprotein 0.0629699
MACF1 microtubule-actin crosslinking factor 1 0.0626321
LDHA lactate dehydrogenase A 0.0625718
HMGA1 high mobility group AT-hook 1 0.0624771
ATXN1 ataxin 1 0.0613612
RACK1 receptor for activated C kinase 1 0.0596995
TPM4 tropomyosin 4 0.058768
SMAD3 SMAD family member 3 0.058229
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0563141
CREB5 cAMP responsive element binding protein 5 0.0562418
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.055326
BBS9 Bardet-Biedl syndrome 9 0.0545526
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0536591
AKAP12 A kinase (PRKA) anchor protein 12 0.0521644
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0518293
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0512232
ZFP36L1 ZFP36 ring finger protein-like 1 0.0509249
SQSTM1 sequestosome 1 0.050397
MYO1D myosin ID 0.0497592
SET SET nuclear proto-oncogene 0.0495048
CYSTM1 cysteine-rich transmembrane module containing 1 0.046546
PHF3 PHD finger protein 3 0.0463114
ENO1 enolase 1, (alpha) 0.0462824
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0460927
SEPTIN9 septin 9 0.0460751
CANX calnexin 0.0456131
MBNL2 muscleblind-like splicing regulator 2 0.0452716
FLNA filamin A, alpha 0.0443222
IQGAP1 IQ motif containing GTPase activating protein 1 0.0439283
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0437589
CAPN2 calpain 2, (m/II) large subunit 0.0437355
RPL12 ribosomal protein L12 0.043232
EIF4A2 eukaryotic translation initiation factor 4A2 0.0426812
MPRIP myosin phosphatase Rho interacting protein 0.0426726
N4BP2L2 NEDD4 binding protein 2-like 2 0.0425585
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0423769
PKM pyruvate kinase, muscle 0.0419154
TTC3 tetratricopeptide repeat domain 3 0.0414554
LPP LIM domain containing preferred translocation partner in lipoma 0.0409196
MACC1 metastasis associated in colon cancer 1 0.0408047
LAMA4 laminin, alpha 4 0.0405045
EGFR epidermal growth factor receptor 0.0404329
CDCP1 CUB domain containing protein 1 0.0399541
EMP1 epithelial membrane protein 1 0.0398013
POTEF POTE ankyrin domain family, member F 0.0394322
TRIM2 tripartite motif containing 2 0.0392355
JMJD1C jumonji domain containing 1C 0.0390847
KRT19 keratin 19, type I 0.0390492
SNX9 sorting nexin 9 0.0390211
RPL5 ribosomal protein L5 0.0385212
VMP1 vacuole membrane protein 1 0.0381735
EREG epiregulin 0.0381524
VCAN versican 0.0374828
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0373122
MACROD2 MACRO domain containing 2 0.036728
RPL3 ribosomal protein L3 0.0363756
OPTN optineurin 0.0360988
AHNAK2 AHNAK nucleoprotein 2 0.0360639
NCEH1 neutral cholesterol ester hydrolase 1 0.0357617
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0356318
FNIP1 folliculin interacting protein 1 0.0353632
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0352386
EZR ezrin 0.0351285
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0349791
MYADM myeloid-associated differentiation marker 0.0348519

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0527034
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0519119
DIAPH3 diaphanous-related formin 3 -0.0461113
TMSB10 thymosin beta 10 -0.0426483
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0412781
RPL35A ribosomal protein L35a -0.0410613
RPS19 ribosomal protein S19 -0.040779
PTMA prothymosin, alpha -0.0388741
RPLP1 ribosomal protein, large, P1 -0.0367485
SMC4 structural maintenance of chromosomes 4 -0.0364959
FTL ferritin, light polypeptide -0.035001
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0329169
RBM25 RNA binding motif protein 25 -0.0321513
HMGB1 high mobility group box 1 -0.0302422
WSB1 WD repeat and SOCS box containing 1 -0.0295323
RNF145 ring finger protein 145 -0.0282771
RPLP2 ribosomal protein, large, P2 -0.0279887
DLG1 discs, large homolog 1 (Drosophila) -0.0276186
PNISR PNN-interacting serine/arginine-rich protein -0.0265783
NUP58 nucleoporin 58 -0.0262149
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0259101
ANLN anillin, actin binding protein -0.0239351
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0237765
KIF18B kinesin family member 18B -0.0234551
HELLS helicase, lymphoid-specific -0.0233944
WDR45B WD repeat domain 45B -0.0232318
GARS1 glycyl-tRNA synthetase 1 -0.0227346
RTN4 reticulon 4 -0.021704
HP1BP3 heterochromatin protein 1, binding protein 3 -0.021594
GSTP1 glutathione S-transferase pi 1 -0.0215231
IARS1 isoleucyl-tRNA synthetase 1 -0.0215022
TUBB4B tubulin, beta 4B class IVb -0.0214797
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0214206
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0214074
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0213695
MYL12B myosin, light chain 12B, regulatory -0.0213452
DEK DEK proto-oncogene -0.0211045
RRM2 ribonucleotide reductase M2 -0.0210434
IGFBP3 insulin-like growth factor binding protein 3 -0.0209534
MIDEAS mitotic deacetylase associated SANT domain protein -0.0208199
MKI67 marker of proliferation Ki-67 -0.0207422
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0204386
PDE4D phosphodiesterase 4D, cAMP-specific -0.0202867
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0202277
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0200244
IER3 immediate early response 3 -0.0195516
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0192478
NIBAN1 niban apoptosis regulator 1 -0.0186387
GAS2L3 growth arrest-specific 2 like 3 -0.0184714
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0180517
BARD1 BRCA1 associated RING domain 1 -0.0178546
UBP1 upstream binding protein 1 (LBP-1a) -0.017852
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa -0.0176606
VIM vimentin -0.0174766
SUZ12 SUZ12 polycomb repressive complex 2 subunit -0.0173905
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0171655
TSC22D2 TSC22 domain family, member 2 -0.0171631
NEMF nuclear export mediator factor -0.01697
RRBP1 ribosome binding protein 1 -0.0168885
TUBB tubulin, beta class I -0.0168401
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0167532
FANCI Fanconi anemia, complementation group I -0.01674
LAMA5 laminin, alpha 5 -0.0166878
NPR2 natriuretic peptide receptor 2 -0.0166377
CAMTA1 calmodulin binding transcription activator 1 -0.0166063
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0165346
LIMCH1 LIM and calponin homology domains 1 -0.0164445
UBE2K ubiquitin-conjugating enzyme E2K -0.0163458
SMC1A structural maintenance of chromosomes 1A -0.0162223
TRAPPC10 trafficking protein particle complex 10 -0.0161963
SEC61G Sec61 gamma subunit -0.0160619
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0160371
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0158494
XPO7 exportin 7 -0.0158072
EIF5B eukaryotic translation initiation factor 5B -0.0157088
FAM162A family with sequence similarity 162, member A -0.0156835
R3HDM1 R3H domain containing 1 -0.0155518
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0154733
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0153461
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0152334
FOXK2 forkhead box K2 -0.0152155
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.015181
AGRN agrin -0.0149126
XPO1 exportin 1 -0.0148469
XPO6 exportin 6 -0.0148342
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0147968
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0147293
MT1X metallothionein 1X -0.0145612
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0144974
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.014379
NCAPD3 non-SMC condensin II complex, subunit D3 -0.0143527
ATAD2 ATPase family, AAA domain containing 2 -0.0142719
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0142132
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0141616
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.014115
PRDX1 peroxiredoxin 1 -0.0140728
LENG8 leukocyte receptor cluster (LRC) member 8 -0.014065
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0140605
REV1 REV1, polymerase (DNA directed) -0.0140328
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -0.0138213