AZD-8055_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.152039
VIM vimentin 0.144173
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.132892
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.108339
TRIO trio Rho guanine nucleotide exchange factor 0.0916315
EXT1 exostosin glycosyltransferase 1 0.0915526
TPT1 tumor protein, translationally-controlled 1 0.0909838
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0885263
ANKRD28 ankyrin repeat domain 28 0.0819938
ZBTB20 zinc finger and BTB domain containing 20 0.0713146
NAV2 neuron navigator 2 0.0691535
NAV1 neuron navigator 1 0.0680715
COL5A1 collagen, type V, alpha 1 0.0668684
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0632378
AHNAK AHNAK nucleoprotein 0.0629151
FNIP1 folliculin interacting protein 1 0.0616652
RAI14 retinoic acid induced 14 0.0598318
SQSTM1 sequestosome 1 0.0585958
AKAP12 A kinase (PRKA) anchor protein 12 0.0575915
RPS6 ribosomal protein S6 0.0569759
CDH13 cadherin 13 0.054175
DST dystonin 0.0536307
IGF1R insulin-like growth factor 1 receptor 0.0535224
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0525614
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0506922
GOLGB1 golgin B1 0.0502851
BACE2 beta-site APP-cleaving enzyme 2 0.0486511
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0485199
EIF1 eukaryotic translation initiation factor 1 0.0464573
PCBP3 poly(rC) binding protein 3 0.0459478
RPL12 ribosomal protein L12 0.0452199
RPS8 ribosomal protein S8 0.045217
ACTG1 actin gamma 1 0.0436357
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.043422
CD44 CD44 molecule (Indian blood group) 0.0433757
MT1E metallothionein 1E 0.0430977
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0422966
RND3 Rho family GTPase 3 0.0417588
DOCK5 dedicator of cytokinesis 5 0.0408489
MYOF myoferlin 0.0392446
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0378038
NDRG1 N-myc downstream regulated 1 0.0376705
PLEC plectin 0.0371004
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0358586
EMP1 epithelial membrane protein 1 0.0358332
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0354495
LRMDA leucine rich melanocyte differentiation associated 0.035235
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.034835
BBS9 Bardet-Biedl syndrome 9 0.033991
ATXN1 ataxin 1 0.033597
MACF1 microtubule-actin crosslinking factor 1 0.0333843
PHF3 PHD finger protein 3 0.0333273
CTSB cathepsin B 0.0329704
RPL31 ribosomal protein L31 0.0328979
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0323102
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0319366
TNS1 tensin 1 0.0316545
MYO9A myosin IXA 0.0315891
RPL9 ribosomal protein L9 0.0308556
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0306293
HLA-E major histocompatibility complex, class I, E 0.0305558
SLIT2 slit homolog 2 (Drosophila) 0.0304999
BPTF bromodomain PHD finger transcription factor 0.0302708
TNS3 tensin 3 0.0302333
SFTPA2 surfactant protein A2 0.0299011
EEF2 eukaryotic translation elongation factor 2 0.029663
VEGFA vascular endothelial growth factor A 0.0295539
HSPA8 heat shock 70kDa protein 8 0.029516
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0295061
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0288488
AEBP2 AE binding protein 2 0.0287243
INHBA inhibin, beta A 0.0284793
CUX1 cut-like homeobox 1 0.0284204
ANTXR1 anthrax toxin receptor 1 0.028406
RPL37A ribosomal protein L37a 0.027981
N4BP2L2 NEDD4 binding protein 2-like 2 0.0277921
RPS3 ribosomal protein S3 0.0277446
RPL26 ribosomal protein L26 0.0276673
RPL23 ribosomal protein L23 0.0273058
PALLD palladin, cytoskeletal associated protein 0.0271421
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0267142
RPL19 ribosomal protein L19 0.0266366
MMP12 matrix metallopeptidase 12 0.0266221
KYNU kynureninase 0.026593
INTS6 integrator complex subunit 6 0.0265652
RPS2 ribosomal protein S2 0.0264662
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0264628
DENND5B DENN/MADD domain containing 5B 0.0260032
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0259485
RPL37 ribosomal protein L37 0.0259295
PODXL podocalyxin-like 0.0258883
ENO2 enolase 2 (gamma, neuronal) 0.0258842
FOXP1 forkhead box P1 0.025525
RPL11 ribosomal protein L11 0.0254294
MBD5 methyl-CpG binding domain protein 5 0.0247842
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0246803
NALF1 NALCN channel auxiliary factor 1 0.0245278
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0244988
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0241618
FAM107B family with sequence similarity 107, member B 0.0241012

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254467
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.252819
FN1 fibronectin 1 -0.154997
ELL2 elongation factor, RNA polymerase II, 2 -0.09472
TMSB10 thymosin beta 10 -0.0810163
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0751214
PTMA prothymosin, alpha -0.0656322
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0621102
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0561615
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.05353
EGR1 early growth response 1 -0.0522484
RRM2 ribonucleotide reductase M2 -0.0515127
IGFBP3 insulin-like growth factor binding protein 3 -0.05059
RTN4 reticulon 4 -0.0469381
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0450811
IGF2 insulin-like growth factor 2 -0.0421068
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0413903
GLIS3 GLIS family zinc finger 3 -0.0411192
PGK1 phosphoglycerate kinase 1 -0.0391128
NECTIN2 nectin cell adhesion molecule 2 -0.0383379
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0382852
SMC4 structural maintenance of chromosomes 4 -0.0382031
CENPF centromere protein F, 350/400kDa -0.0380056
TENM2 teneurin transmembrane protein 2 -0.037882
MAP1B microtubule-associated protein 1B -0.0376404
PKM pyruvate kinase, muscle -0.0363469
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0355269
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0354998
PLAUR plasminogen activator, urokinase receptor -0.0350037
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0348031
WDR45B WD repeat domain 45B -0.0345064
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0340626
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0335641
TPX2 TPX2, microtubule-associated -0.0324274
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0319998
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0316952
FAM13A family with sequence similarity 13, member A -0.0309165
PDIA3 protein disulfide isomerase family A, member 3 -0.0308477
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0306887
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0305331
NAMPT nicotinamide phosphoribosyltransferase -0.0302901
NUP58 nucleoporin 58 -0.0301909
PDIA6 protein disulfide isomerase family A, member 6 -0.0301335
USP3 ubiquitin specific peptidase 3 -0.0296528
SPAG9 sperm associated antigen 9 -0.0291874
CCND1 cyclin D1 -0.0288606
POTEF POTE ankyrin domain family, member F -0.0288425
MSN moesin -0.0284471
ACTN4 actinin, alpha 4 -0.0283391
TGFBI transforming growth factor, beta-induced, 68kDa -0.0282499
MKI67 marker of proliferation Ki-67 -0.0282057
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0269341
YBX1 Y box binding protein 1 -0.0268832
CLIC4 chloride intracellular channel 4 -0.0267019
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0263955
ZFAND3 zinc finger, AN1-type domain 3 -0.0261746
MIS18BP1 MIS18 binding protein 1 -0.0261577
DIAPH3 diaphanous-related formin 3 -0.0259255
RNF145 ring finger protein 145 -0.0258758
ANLN anillin, actin binding protein -0.0255195
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0252856
RRBP1 ribosome binding protein 1 -0.025012
LDHA lactate dehydrogenase A -0.0249718
TUBB6 tubulin, beta 6 class V -0.0246979
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0246379
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0240462
LOC112694756 uncharaterized LOC112694756 -0.0240461
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0240317
SPRED1 sprouty-related, EVH1 domain containing 1 -0.023774
COL1A1 collagen, type I, alpha 1 -0.0233795
SGO2 shugoshin 2 -0.0232129
DNMBP dynamin binding protein -0.0230356
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0229923
SEC24A SEC24 family member A -0.0226078
CALU calumenin -0.0222385
CENPE centromere protein E, 312kDa -0.0222197
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0218708
XPO1 exportin 1 -0.0218278
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0215921
HJURP Holliday junction recognition protein -0.0215771
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0213768
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0213503
SETD5 SET domain containing 5 -0.0211203
CKAP5 cytoskeleton associated protein 5 -0.0210201
VASP vasodilator-stimulated phosphoprotein -0.0209089
NGLY1 N-glycanase 1 -0.0207836
SUCO SUN domain containing ossification factor -0.0207482
DLG1 discs, large homolog 1 (Drosophila) -0.020583
FOSL1 FOS-like antigen 1 -0.0204097
SEPTIN7 septin 7 -0.0203868
ACTN1 actinin, alpha 1 -0.0203529
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0203394
RNMT RNA (guanine-7-) methyltransferase -0.0202371
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0200953
LCORL ligand dependent nuclear receptor corepressor-like -0.0200916
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.0200734
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.019848
TNIP1 TNFAIP3 interacting protein 1 -0.0198432
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0198387
TM9SF3 transmembrane 9 superfamily member 3 -0.0195357