| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.167502 |
| NDRG1 | N-myc downstream regulated 1 | 0.162876 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.15833 |
| VEGFA | vascular endothelial growth factor A | 0.152255 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.150616 |
| CDH13 | cadherin 13 | 0.133142 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.111975 |
| EXT1 | exostosin glycosyltransferase 1 | 0.105774 |
| STC1 | stanniocalcin 1 | 0.1021 |
| FNDC3B | fibronectin type III domain containing 3B | 0.100116 |
| GOLGB1 | golgin B1 | 0.0965896 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.071508 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0691828 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0686629 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0665437 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0625435 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0603763 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0603164 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.05966 |
| FN1 | fibronectin 1 | 0.0567067 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0503472 |
| EGFR | epidermal growth factor receptor | 0.0493068 |
| GLIS3 | GLIS family zinc finger 3 | 0.0484328 |
| NAV2 | neuron navigator 2 | 0.0474655 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0473607 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0471928 |
| CLMP | CXADR-like membrane protein | 0.0453288 |
| GOLGA4 | golgin A4 | 0.0449752 |
| DOCK5 | dedicator of cytokinesis 5 | 0.044734 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0437312 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0434389 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0434146 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0431973 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0428096 |
| FBN1 | fibrillin 1 | 0.0425994 |
| FNIP1 | folliculin interacting protein 1 | 0.0424497 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0423172 |
| NAV1 | neuron navigator 1 | 0.0421319 |
| HM13 | histocompatibility (minor) 13 | 0.041446 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0407431 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0401792 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0389116 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0388586 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0388362 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0388341 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0379357 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0377617 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0376951 |
| SP100 | SP100 nuclear antigen | 0.037578 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0375008 |
| PGM3 | phosphoglucomutase 3 | 0.0370626 |
| CD44 | CD44 molecule (Indian blood group) | 0.0368593 |
| FAM107B | family with sequence similarity 107, member B | 0.0368544 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.0364533 |
| FMNL2 | formin-like 2 | 0.0362574 |
| MTSS1 | metastasis suppressor 1 | 0.0360963 |
| RND3 | Rho family GTPase 3 | 0.035883 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0358616 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0342303 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0339265 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0339139 |
| RPS2 | ribosomal protein S2 | 0.0338834 |
| MMP3 | matrix metallopeptidase 3 | 0.0336852 |
| MLF1 | myeloid leukemia factor 1 | 0.0332664 |
| PLEC | plectin | 0.0331103 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0326532 |
| CMIP | c-Maf inducing protein | 0.0322673 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0321284 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0320313 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0320113 |
| CLTC | clathrin, heavy chain (Hc) | 0.0315099 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0307687 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0304099 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0294813 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0290182 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0288868 |
| CDK13 | cyclin-dependent kinase 13 | 0.0286845 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0285326 |
| ATXN1 | ataxin 1 | 0.0282705 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0282665 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.027928 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0278573 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0278276 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0276922 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0275162 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0274663 |
| BRD2 | bromodomain containing 2 | 0.0273472 |
| IL6 | interleukin 6 | 0.0273004 |
| TMF1 | TATA element modulatory factor 1 | 0.0269783 |
| SQSTM1 | sequestosome 1 | 0.0266777 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0266251 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0264418 |
| MTDH | metadherin | 0.0262244 |
| SDC2 | syndecan 2 | 0.026179 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0260961 |
| VMP1 | vacuole membrane protein 1 | 0.0258489 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0257623 |
| ATF4 | activating transcription factor 4 | 0.0254849 |
| MYO10 | myosin X | 0.0252849 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0250822 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.307188 |
| VIM | vimentin | -0.165205 |
| COL1A1 | collagen, type I, alpha 1 | -0.145184 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0791517 |
| PTMA | prothymosin, alpha | -0.0781607 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0745944 |
| TMSB10 | thymosin beta 10 | -0.0491015 |
| COL1A2 | collagen, type I, alpha 2 | -0.0453001 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0425492 |
| ATP13A3 | ATPase type 13A3 | -0.040061 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0393351 |
| ANXA2 | annexin A2 | -0.038172 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0379969 |
| USP3 | ubiquitin specific peptidase 3 | -0.0365668 |
| CANX | calnexin | -0.035477 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0353868 |
| RTN4 | reticulon 4 | -0.0340452 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0335306 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0314728 |
| FTL | ferritin, light polypeptide | -0.0305004 |
| PGK1 | phosphoglycerate kinase 1 | -0.0300052 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0299226 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0299098 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0294624 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0288089 |
| CAVIN1 | caveolae associated protein 1 | -0.0285699 |
| CALR | calreticulin | -0.0276785 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0272412 |
| RPL35A | ribosomal protein L35a | -0.0271938 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0259381 |
| YBX1 | Y box binding protein 1 | -0.0259054 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0255378 |
| SEPTIN7 | septin 7 | -0.0255179 |
| ZNF292 | zinc finger protein 292 | -0.0246305 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0241634 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0241608 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0240483 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0239516 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0239275 |
| MT2A | metallothionein 2A | -0.0237365 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.023694 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0230848 |
| HMGB1 | high mobility group box 1 | -0.0219858 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0211496 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0206635 |
| ANLN | anillin, actin binding protein | -0.0201489 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0200797 |
| QKI | QKI, KH domain containing, RNA binding | -0.0200785 |
| TPM4 | tropomyosin 4 | -0.0197605 |
| MT1X | metallothionein 1X | -0.0197076 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0196475 |
| OGA | O-GlcNAcase | -0.019619 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0195951 |
| RHEB | Ras homolog enriched in brain | -0.0192487 |
| FAM162A | family with sequence similarity 162, member A | -0.019225 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0191243 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0190986 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0190903 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0190796 |
| RPL19 | ribosomal protein L19 | -0.01889 |
| IER3 | immediate early response 3 | -0.0184921 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0183565 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0180551 |
| ECT2 | epithelial cell transforming 2 | -0.0177117 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0175489 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0175275 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0173239 |
| RPL12 | ribosomal protein L12 | -0.0172949 |
| TUBA1B | tubulin, alpha 1b | -0.0170846 |
| TMSB4X | thymosin beta 4, X-linked | -0.0170453 |
| WDR45B | WD repeat domain 45B | -0.0168549 |
| HMGB2 | high mobility group box 2 | -0.0166067 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0164691 |
| RNF145 | ring finger protein 145 | -0.0163476 |
| RPS27A | ribosomal protein S27a | -0.0161081 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0158231 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0158003 |
| SMAD3 | SMAD family member 3 | -0.0157587 |
| RPS24 | ribosomal protein S24 | -0.0156257 |
| RPLP1 | ribosomal protein, large, P1 | -0.015598 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0155657 |
| PXDN | peroxidasin | -0.0152753 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0152735 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0152704 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0151786 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0149748 |
| XPO7 | exportin 7 | -0.0149546 |
| MTF2 | metal response element binding transcription factor 2 | -0.0149164 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0148494 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0147321 |
| RPL23 | ribosomal protein L23 | -0.014487 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0143767 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0143163 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0142739 |
| TMEM123 | transmembrane protein 123 | -0.0142368 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0141844 |
| ITGAV | integrin, alpha V | -0.0141002 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0140419 |
| HAS2 | hyaluronan synthase 2 | -0.0139846 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0139482 |
