| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.228422 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.120476 |
| SMAD3 | SMAD family member 3 | 0.107349 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0925976 |
| EMP1 | epithelial membrane protein 1 | 0.0897142 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0768211 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0695835 |
| FAT1 | FAT atypical cadherin 1 | 0.0651999 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0641196 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0635516 |
| NDRG1 | N-myc downstream regulated 1 | 0.0605472 |
| EXPH5 | exophilin 5 | 0.0601796 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0597755 |
| KRT18 | keratin 18, type I | 0.0596081 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0585401 |
| FNDC3B | fibronectin type III domain containing 3B | 0.056519 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0548781 |
| MYADM | myeloid-associated differentiation marker | 0.0518065 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0469149 |
| SGMS2 | sphingomyelin synthase 2 | 0.0458463 |
| TMEM65 | transmembrane protein 65 | 0.0457914 |
| PDZD8 | PDZ domain containing 8 | 0.0456435 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0454652 |
| ATXN1 | ataxin 1 | 0.0453619 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0451088 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0448632 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0436628 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0435463 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0434588 |
| UTRN | utrophin | 0.0434184 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0426306 |
| SEPTIN9 | septin 9 | 0.0426258 |
| NTN4 | netrin 4 | 0.042367 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0417451 |
| GOLGB1 | golgin B1 | 0.041056 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0387233 |
| SIK3 | SIK family kinase 3 | 0.0378418 |
| KRT20 | keratin 20, type I | 0.0375072 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0370253 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0366901 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.036677 |
| FOXO1 | forkhead box O1 | 0.0348309 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0329037 |
| ASPH | aspartate beta-hydroxylase | 0.0327637 |
| RPS2 | ribosomal protein S2 | 0.0326839 |
| PDE10A | phosphodiesterase 10A | 0.0322749 |
| RASEF | RAS and EF-hand domain containing | 0.0318325 |
| ITGA1 | integrin, alpha 1 | 0.0314909 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0314378 |
| SLTM | SAFB-like, transcription modulator | 0.0312189 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0312044 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0305223 |
| TLE4 | transducin-like enhancer of split 4 | 0.0299383 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0284989 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0281223 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0263428 |
| FRY | furry homolog (Drosophila) | 0.0263185 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0260839 |
| FBXO32 | F-box protein 32 | 0.0252954 |
| LAMA4 | laminin, alpha 4 | 0.025235 |
| RPL21 | ribosomal protein L21 | 0.0250264 |
| DST | dystonin | 0.0244541 |
| MYO1E | myosin IE | 0.0242057 |
| JMJD1C | jumonji domain containing 1C | 0.0241935 |
| EZR | ezrin | 0.0239799 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0239197 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0234267 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.023299 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.023007 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0227988 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0226471 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0220238 |
| ATXN7L1 | ataxin 7-like 1 | 0.0218056 |
| ACVR1 | activin A receptor, type I | 0.021664 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0215571 |
| CA12 | carbonic anhydrase XII | 0.0211086 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0210926 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0210849 |
| ABHD2 | abhydrolase domain containing 2 | 0.021039 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0207814 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0207589 |
| TXNRD1 | thioredoxin reductase 1 | 0.0207499 |
| PLK2 | polo-like kinase 2 | 0.0206572 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0204272 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0203903 |
| HM13 | histocompatibility (minor) 13 | 0.0201564 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0201215 |
| HMGA1 | high mobility group AT-hook 1 | 0.0198862 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0197985 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0197754 |
| RAB22A | RAB22A, member RAS oncogene family | 0.019353 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0190738 |
| CAB39 | calcium binding protein 39 | 0.0190592 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0188437 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.0188241 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0187408 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0186451 |
| CCNYL1 | cyclin Y-like 1 | 0.0184332 |
| YAP1 | Yes-associated protein 1 | 0.0181674 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0181253 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.0864099 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0768857 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0689454 |
| EGR1 | early growth response 1 | -0.0645868 |
| VCL | vinculin | -0.0624744 |
| PRELID2 | PRELI domain containing 2 | -0.0624191 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0609341 |
| ACTN4 | actinin, alpha 4 | -0.0594502 |
| FTL | ferritin, light polypeptide | -0.0587055 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0570152 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0558835 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0529686 |
| ANXA2 | annexin A2 | -0.051338 |
| JUN | jun proto-oncogene | -0.0504861 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0495435 |
| MKI67 | marker of proliferation Ki-67 | -0.0470262 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0437271 |
| RNF213 | ring finger protein 213 | -0.0428082 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0426516 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0416973 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0416428 |
| AHNAK | AHNAK nucleoprotein | -0.0391736 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0381557 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0368798 |
| PGK1 | phosphoglycerate kinase 1 | -0.0353708 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0340149 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0329398 |
| STK24 | serine/threonine kinase 24 | -0.0324271 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0321281 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0320589 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0318531 |
| FOXO3 | forkhead box O3 | -0.031582 |
| MECOM | MDS1 and EVI1 complex locus | -0.0310913 |
| S100A10 | S100 calcium binding protein A10 | -0.0295447 |
| ACTG1 | actin gamma 1 | -0.0293608 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0290655 |
| NF1 | neurofibromin 1 | -0.0285298 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0278301 |
| ETV6 | ets variant 6 | -0.0275911 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0266786 |
| WASF2 | WAS protein family, member 2 | -0.0264153 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0262857 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0261251 |
| GNAS | GNAS complex locus | -0.0260226 |
| INTS6 | integrator complex subunit 6 | -0.0259009 |
| CENPF | centromere protein F, 350/400kDa | -0.0257828 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0257724 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0253811 |
| RPL35A | ribosomal protein L35a | -0.0253651 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0253548 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0253332 |
| CD2AP | CD2-associated protein | -0.0252295 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0250611 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0250309 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0250247 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0248455 |
| RPL37A | ribosomal protein L37a | -0.0247199 |
| ADIPOR2 | adiponectin receptor 2 | -0.0244965 |
| SDC4 | syndecan 4 | -0.0242375 |
| TPM4 | tropomyosin 4 | -0.0240111 |
| JUP | junction plakoglobin | -0.0236608 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0234065 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0233419 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0232969 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0230584 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0228668 |
| RTN3 | reticulon 3 | -0.0228026 |
| DIAPH3 | diaphanous-related formin 3 | -0.0225248 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0225201 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.022419 |
| TUFT1 | tuftelin 1 | -0.0221366 |
| DGKH | diacylglycerol kinase, eta | -0.0218812 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0216387 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0214637 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0213454 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0213167 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0212568 |
| BPTF | bromodomain PHD finger transcription factor | -0.0210226 |
| KRT19 | keratin 19, type I | -0.0209948 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0208227 |
| RPLP1 | ribosomal protein, large, P1 | -0.0207974 |
| TNS3 | tensin 3 | -0.0207329 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0205885 |
| NPSR1 | neuropeptide S receptor 1 | -0.0205674 |
| ANXA3 | annexin A3 | -0.020371 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0202832 |
| ANXA4 | annexin A4 | -0.0201887 |
| LIPH | lipase, member H | -0.020047 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0196325 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0194823 |
| SERINC5 | serine incorporator 5 | -0.0192979 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0191201 |
| RBM47 | RNA binding motif protein 47 | -0.0190904 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0190436 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0190388 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | -0.0190262 |
| INSIG1 | insulin induced gene 1 | -0.0189586 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0188042 |
| HKDC1 | hexokinase domain containing 1 | -0.0187354 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0187015 |
