| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-8055_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.5509 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.353097 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.106019 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0895046 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0774416 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0763003 |
| ASPH | aspartate beta-hydroxylase | 0.075164 |
| DSPP | dentin sialophosphoprotein | 0.0735428 |
| SVIL | supervillin | 0.0700697 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0632568 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0629194 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0614514 |
| FAM107B | family with sequence similarity 107, member B | 0.0472159 |
| ATXN1 | ataxin 1 | 0.0455548 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0448734 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0417893 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0410042 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0388757 |
| NDRG1 | N-myc downstream regulated 1 | 0.0388512 |
| FRMD5 | FERM domain containing 5 | 0.0371243 |
| FOXP1 | forkhead box P1 | 0.0350794 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0339943 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0339887 |
| HMGA1 | high mobility group AT-hook 1 | 0.0332803 |
| VEGFA | vascular endothelial growth factor A | 0.0331248 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0329382 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0329196 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0327366 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0307518 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0302341 |
| KYNU | kynureninase | 0.0301001 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.030085 |
| RPL3 | ribosomal protein L3 | 0.0281396 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0280987 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0279886 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.02753 |
| PLIN2 | perilipin 2 | 0.0260038 |
| DST | dystonin | 0.0257038 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0255317 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0248783 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0244217 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0239167 |
| DTNA | dystrobrevin, alpha | 0.023893 |
| FLNB | filamin B, beta | 0.0237582 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0230959 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0229604 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0225349 |
| OPTN | optineurin | 0.0225346 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0221111 |
| ARFGEF3 | ARFGEF family member 3 | 0.0217873 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0211295 |
| ENO1 | enolase 1, (alpha) | 0.0210626 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0209642 |
| DIAPH1 | diaphanous-related formin 1 | 0.020775 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0204734 |
| CRY1 | cryptochrome circadian clock 1 | 0.0200672 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0199662 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0196771 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.019513 |
| RPS18 | ribosomal protein S18 | 0.019499 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0194639 |
| TNS1 | tensin 1 | 0.0191491 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0189099 |
| RASA2 | RAS p21 protein activator 2 | 0.0185869 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0183022 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0180932 |
| RPS2 | ribosomal protein S2 | 0.0180756 |
| FERMT2 | fermitin family member 2 | 0.0180428 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.0178712 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0178658 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0178047 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0176266 |
| ANO6 | anoctamin 6 | 0.0175787 |
| MYO6 | myosin VI | 0.0170973 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0166355 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0165564 |
| BRD2 | bromodomain containing 2 | 0.0165219 |
| JAK1 | Janus kinase 1 | 0.0164885 |
| RAI14 | retinoic acid induced 14 | 0.0163351 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0163275 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0162081 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0160395 |
| ITGA6 | integrin, alpha 6 | 0.0160202 |
| JAG1 | jagged 1 | 0.015859 |
| UBN2 | ubinuclein 2 | 0.0156139 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0155655 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0155618 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0153169 |
| NGLY1 | N-glycanase 1 | 0.0152011 |
| POTEF | POTE ankyrin domain family, member F | 0.0151442 |
| INTS6 | integrator complex subunit 6 | 0.0151205 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0149972 |
| PAPOLA | poly(A) polymerase alpha | 0.014964 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0149116 |
| TXNRD1 | thioredoxin reductase 1 | 0.0148851 |
| RPL21 | ribosomal protein L21 | 0.0147499 |
| STC2 | stanniocalcin 2 | 0.0147158 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0146604 |
| FAM13A | family with sequence similarity 13, member A | 0.014649 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0144495 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.222143 |
| APOB | apolipoprotein B | -0.163212 |
| GPC3 | glypican 3 | -0.126569 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0975268 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0891447 |
| FN1 | fibronectin 1 | -0.0747979 |
| A2M | alpha-2-macroglobulin | -0.0744098 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0730012 |
| TRIM26 | tripartite motif containing 26 | -0.0716967 |
| CP | ceruloplasmin (ferroxidase) | -0.0569524 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0549986 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0541245 |
| FTL | ferritin, light polypeptide | -0.0539 |
| GNAS | GNAS complex locus | -0.0497652 |
| APOA2 | apolipoprotein A-II | -0.0486173 |
| APOE | apolipoprotein E | -0.0475215 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0461088 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0439281 |
| RPS24 | ribosomal protein S24 | -0.042456 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0422771 |
| AHSG | alpha-2-HS-glycoprotein | -0.0396689 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0394353 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0392633 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0374306 |
| RPL35A | ribosomal protein L35a | -0.036902 |
| IER3 | immediate early response 3 | -0.0364474 |
| RPLP1 | ribosomal protein, large, P1 | -0.0361561 |
| TMEM123 | transmembrane protein 123 | -0.0357017 |
| SDC4 | syndecan 4 | -0.0355751 |
| APOA1 | apolipoprotein A-I | -0.0349932 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0345796 |
| RPL11 | ribosomal protein L11 | -0.0345209 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0340715 |
| SELENOP | selenoprotein P | -0.0334899 |
| MT2A | metallothionein 2A | -0.03327 |
| RPS19 | ribosomal protein S19 | -0.0321806 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0321069 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0317453 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0307535 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0304988 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0295853 |
| RRBP1 | ribosome binding protein 1 | -0.0295752 |
| RPL34 | ribosomal protein L34 | -0.0290521 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0284062 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0272612 |
| LYZ | lysozyme | -0.026891 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0266356 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0262921 |
| NPR2 | natriuretic peptide receptor 2 | -0.0256991 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0255158 |
| GDF15 | growth differentiation factor 15 | -0.0253008 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0251351 |
| EGR1 | early growth response 1 | -0.0244941 |
| PTMA | prothymosin, alpha | -0.0244839 |
| RPL12 | ribosomal protein L12 | -0.0244779 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0239289 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0237463 |
| RBM25 | RNA binding motif protein 25 | -0.0230855 |
| PTCHD4 | patched domain containing 4 | -0.0229871 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0229177 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0228405 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0221915 |
| AGXT | alanine-glyoxylate aminotransferase | -0.0216054 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0215331 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0211575 |
| RPS27A | ribosomal protein S27a | -0.0207954 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0206777 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0199692 |
| RPL31 | ribosomal protein L31 | -0.0199167 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0195943 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0195491 |
| FABP1 | fatty acid binding protein 1, liver | -0.0193771 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0192055 |
| RPS29 | ribosomal protein S29 | -0.019112 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0189713 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0189585 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.018561 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0185239 |
| TF | transferrin | -0.0184917 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0184083 |
| OLA1 | Obg-like ATPase 1 | -0.0184065 |
| MALT1 | MALT1 paracaspase | -0.0182704 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0180793 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.017976 |
| ARF1 | ADP-ribosylation factor 1 | -0.0178121 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.0177159 |
| RPS23 | ribosomal protein S23 | -0.0175859 |
| BPIFB2 | BPI fold containing family B, member 2 | -0.017563 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0175573 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0175316 |
| R3HDM1 | R3H domain containing 1 | -0.0174354 |
| RPL27A | ribosomal protein L27a | -0.0172147 |
| CALR | calreticulin | -0.0171523 |
| RPL13A | ribosomal protein L13a | -0.0169579 |
| HMGA2 | high mobility group AT-hook 2 | -0.016902 |
| APOC1 | apolipoprotein C-I | -0.0168038 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0166522 |
| TLK1 | tousled-like kinase 1 | -0.0165826 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0165702 |
| RPLP0 | ribosomal protein, large, P0 | -0.0165666 |
