| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-8055_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RAI14 | retinoic acid induced 14 | 0.110474 |
| LMO7 | LIM domain 7 | 0.0960688 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0943753 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0874684 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0802075 |
| MYOF | myoferlin | 0.0769267 |
| HLA-E | major histocompatibility complex, class I, E | 0.0709959 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0640235 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0629129 |
| MSN | moesin | 0.0610126 |
| RPS2 | ribosomal protein S2 | 0.0549953 |
| EFNA5 | ephrin-A5 | 0.0522696 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0521158 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0506048 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0483219 |
| JMJD1C | jumonji domain containing 1C | 0.0480763 |
| TGM2 | transglutaminase 2 | 0.0475529 |
| UTRN | utrophin | 0.0475197 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0451271 |
| MT2A | metallothionein 2A | 0.0444884 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0412603 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0406288 |
| CD44 | CD44 molecule (Indian blood group) | 0.040561 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0405475 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0392752 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0391011 |
| MT1E | metallothionein 1E | 0.038671 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0381232 |
| TXNIP | thioredoxin interacting protein | 0.037926 |
| IFI44L | interferon-induced protein 44-like | 0.037344 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0363072 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0350669 |
| FNDC3B | fibronectin type III domain containing 3B | 0.034486 |
| PLS3 | plastin 3 | 0.0344514 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0330855 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0324337 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.032367 |
| ANXA1 | annexin A1 | 0.0320439 |
| PCDH1 | protocadherin 1 | 0.0312728 |
| OSBPL6 | oxysterol binding protein-like 6 | 0.0311202 |
| PRSS23 | protease, serine, 23 | 0.0310924 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0310749 |
| ANO6 | anoctamin 6 | 0.0300753 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0296433 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0295385 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.029487 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0293028 |
| FAM107B | family with sequence similarity 107, member B | 0.0292972 |
| PLEC | plectin | 0.0286562 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0279495 |
| SVIL | supervillin | 0.0277051 |
| CNTNAP3 | contactin associated protein-like 3 | 0.0276726 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0275528 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0272828 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.026791 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0264149 |
| PODXL | podocalyxin-like | 0.0262019 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0260884 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0259174 |
| CLU | clusterin | 0.0253542 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0252451 |
| DHX34 | DEAH (Asp-Glu-Ala-His) box polypeptide 34 | 0.0251896 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0250847 |
| FNIP1 | folliculin interacting protein 1 | 0.0250777 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0247336 |
| SGMS2 | sphingomyelin synthase 2 | 0.024701 |
| IFI44 | interferon-induced protein 44 | 0.0241566 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0241477 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0237692 |
| ATP9A | ATPase, class II, type 9A | 0.0236827 |
| SMAD3 | SMAD family member 3 | 0.0234142 |
| GOLGB1 | golgin B1 | 0.0233892 |
| EXOC4 | exocyst complex component 4 | 0.0232906 |
| MX1 | MX dynamin-like GTPase 1 | 0.0231894 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0229947 |
| IL6ST | interleukin 6 signal transducer | 0.0225448 |
| GPR176 | G protein-coupled receptor 176 | 0.0221665 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0221318 |
| RPL21 | ribosomal protein L21 | 0.0221308 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0221201 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0219005 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0218468 |
| GBP4 | guanylate binding protein 4 | 0.0217089 |
| ADAR | adenosine deaminase, RNA-specific | 0.0216646 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0216345 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.021506 |
| OPTN | optineurin | 0.0213609 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0213075 |
| PMP22 | peripheral myelin protein 22 | 0.0210736 |
| SIK3 | SIK family kinase 3 | 0.0210413 |
| DOK5 | docking protein 5 | 0.0209001 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0206947 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0204917 |
| APP | amyloid beta (A4) precursor protein | 0.0204584 |
| PLA2R1 | phospholipase A2 receptor 1, 180kDa | 0.0204404 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0203382 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0203317 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0203032 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0202304 |
| SULF2 | sulfatase 2 | 0.0201099 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.205007 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.184232 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.144084 |
| PTMA | prothymosin, alpha | -0.138129 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.134855 |
| FLNB | filamin B, beta | -0.118672 |
| TMSB10 | thymosin beta 10 | -0.0934065 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0810154 |
| PGK1 | phosphoglycerate kinase 1 | -0.0786327 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0736363 |
| RPS21 | ribosomal protein S21 | -0.0691128 |
| S100A10 | S100 calcium binding protein A10 | -0.0682538 |
| GNAS | GNAS complex locus | -0.067578 |
| AHNAK | AHNAK nucleoprotein | -0.0616967 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.060616 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0576384 |
| RPS8 | ribosomal protein S8 | -0.0564993 |
| ANXA2 | annexin A2 | -0.0556066 |
| ITGA6 | integrin, alpha 6 | -0.055521 |
| SLC35F3 | solute carrier family 35, member F3 | -0.053952 |
| EMP1 | epithelial membrane protein 1 | -0.0528206 |
| H1-0 | H1.0 linker histone | -0.0522785 |
| MEF2A | myocyte enhancer factor 2A | -0.0520731 |
| RPS24 | ribosomal protein S24 | -0.0512792 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0511805 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0511698 |
| ANLN | anillin, actin binding protein | -0.0510393 |
| RPLP1 | ribosomal protein, large, P1 | -0.04932 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0471246 |
| STC1 | stanniocalcin 1 | -0.0466909 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0442244 |
| RPL35A | ribosomal protein L35a | -0.0441449 |
| CAVIN1 | caveolae associated protein 1 | -0.043516 |
| ENO1 | enolase 1, (alpha) | -0.0434758 |
| RPL23 | ribosomal protein L23 | -0.0433384 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0428691 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0402378 |
| LMNA | lamin A/C | -0.0402239 |
| RPS27A | ribosomal protein S27a | -0.0394411 |
| RPS6 | ribosomal protein S6 | -0.0389966 |
| PKM | pyruvate kinase, muscle | -0.038848 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0384929 |
| OGA | O-GlcNAcase | -0.0379063 |
| S100A2 | S100 calcium binding protein A2 | -0.0375738 |
| RPLP2 | ribosomal protein, large, P2 | -0.0375271 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0373697 |
| RPS19 | ribosomal protein S19 | -0.0373443 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0373418 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0373364 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0371392 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0369911 |
| ACTN4 | actinin, alpha 4 | -0.0361789 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.035844 |
| TMSB4X | thymosin beta 4, X-linked | -0.0356513 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0355454 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0355336 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0347658 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0343729 |
| MKI67 | marker of proliferation Ki-67 | -0.0340445 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0337213 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0335821 |
| HMGB1 | high mobility group box 1 | -0.0331911 |
| IER3 | immediate early response 3 | -0.0331345 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0331252 |
| RPL11 | ribosomal protein L11 | -0.0327001 |
| GOLGA4 | golgin A4 | -0.0320906 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0319368 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0318817 |
| RPL34 | ribosomal protein L34 | -0.0314483 |
| RPS25 | ribosomal protein S25 | -0.031328 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0312227 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0311982 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0309155 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0305551 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0304201 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0303262 |
| YBX1 | Y box binding protein 1 | -0.030087 |
| CALR | calreticulin | -0.0299152 |
| PALLD | palladin, cytoskeletal associated protein | -0.0298016 |
| S100A9 | S100 calcium binding protein A9 | -0.0294247 |
| HLA-B | major histocompatibility complex, class I, B | -0.0293337 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0293276 |
| CANX | calnexin | -0.0292621 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0292549 |
| CALU | calumenin | -0.0291562 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.028944 |
| ACTG1 | actin gamma 1 | -0.0286313 |
| LDHA | lactate dehydrogenase A | -0.0285917 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0285022 |
| SYPL1 | synaptophysin-like 1 | -0.0283783 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0280631 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0278916 |
| DIAPH3 | diaphanous-related formin 3 | -0.0278803 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0274 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0272886 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0271965 |
| RPL27A | ribosomal protein L27a | -0.0270924 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0265995 |
| KRT6A | keratin 6A, type II | -0.0265889 |
| RPLP0 | ribosomal protein, large, P0 | -0.0264944 |
