| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.1919 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.130599 |
| NDRG1 | N-myc downstream regulated 1 | 0.117617 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.106533 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0847497 |
| NAV2 | neuron navigator 2 | 0.0717081 |
| GOLGB1 | golgin B1 | 0.0713149 |
| FN1 | fibronectin 1 | 0.0700177 |
| FAM107B | family with sequence similarity 107, member B | 0.0696765 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0667582 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0612703 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0590776 |
| INTS6 | integrator complex subunit 6 | 0.0549965 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.053338 |
| DST | dystonin | 0.0532558 |
| PHACTR1 | phosphatase and actin regulator 1 | 0.0531982 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0528841 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0520769 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0513138 |
| ZNF841 | zinc finger protein 841 | 0.0507365 |
| LDHA | lactate dehydrogenase A | 0.049931 |
| ANXA1 | annexin A1 | 0.049261 |
| MLF1 | myeloid leukemia factor 1 | 0.0481017 |
| ACTG1 | actin gamma 1 | 0.0474362 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0468431 |
| RND3 | Rho family GTPase 3 | 0.0467399 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0461594 |
| FLNA | filamin A, alpha | 0.0446297 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0437799 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.043464 |
| DTNA | dystrobrevin, alpha | 0.0432088 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0427516 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.042744 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0416653 |
| TLE4 | transducin-like enhancer of split 4 | 0.0407265 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0407252 |
| VEGFA | vascular endothelial growth factor A | 0.040327 |
| ASPH | aspartate beta-hydroxylase | 0.0398236 |
| ATXN1 | ataxin 1 | 0.0398223 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0398169 |
| SMAD3 | SMAD family member 3 | 0.0389839 |
| PODXL | podocalyxin-like | 0.037957 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0372475 |
| MSN | moesin | 0.0371979 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0361513 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0360836 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0354852 |
| ZNF432 | zinc finger protein 432 | 0.0354451 |
| RPS2 | ribosomal protein S2 | 0.035164 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0345942 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0342263 |
| ACTN1 | actinin, alpha 1 | 0.0340284 |
| POTEF | POTE ankyrin domain family, member F | 0.0338656 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0333367 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0331273 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0328524 |
| FNIP1 | folliculin interacting protein 1 | 0.0325794 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0323506 |
| CD44 | CD44 molecule (Indian blood group) | 0.0321723 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0316262 |
| ANO6 | anoctamin 6 | 0.0316015 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.031455 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0310853 |
| BRD2 | bromodomain containing 2 | 0.0303445 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0301248 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0299043 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0297776 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0295672 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0293461 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0290021 |
| KLF12 | Kruppel-like factor 12 | 0.0282877 |
| SEPTIN9 | septin 9 | 0.0281743 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0278604 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0277706 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0275196 |
| ARFGEF3 | ARFGEF family member 3 | 0.0273771 |
| APP | amyloid beta (A4) precursor protein | 0.0271239 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0270949 |
| MCL1 | myeloid cell leukemia 1 | 0.0269973 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0266977 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0266944 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0265002 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0263099 |
| FMNL2 | formin-like 2 | 0.0260963 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0252334 |
| VCL | vinculin | 0.0252205 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0251037 |
| RPL7 | ribosomal protein L7 | 0.0250181 |
| LOX | lysyl oxidase | 0.025016 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0248994 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0246292 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0245612 |
| MYO1E | myosin IE | 0.0244962 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0243578 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0242865 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0242791 |
| PCBP2 | poly(rC) binding protein 2 | 0.024191 |
| ANO4 | anoctamin 4 | 0.0239318 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0238938 |
| SET | SET nuclear proto-oncogene | 0.0234937 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.214282 |
| HLA-B | major histocompatibility complex, class I, B | -0.16918 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.133803 |
| FTL | ferritin, light polypeptide | -0.112489 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0843477 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0749462 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0735178 |
| TXNRD1 | thioredoxin reductase 1 | -0.0686834 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.065901 |
| PTMA | prothymosin, alpha | -0.0607239 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0588385 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0549213 |
| DEK | DEK proto-oncogene | -0.0481948 |
| SULF1 | sulfatase 1 | -0.0459906 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0455127 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0452481 |
| ARF4 | ADP-ribosylation factor 4 | -0.0446274 |
| RPL35A | ribosomal protein L35a | -0.0445897 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0443886 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0437623 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0434773 |
| CALR | calreticulin | -0.042224 |
| POSTN | periostin, osteoblast specific factor | -0.0420087 |
| TUBB | tubulin, beta class I | -0.0402842 |
| HMGB1 | high mobility group box 1 | -0.0402073 |
| B2M | beta-2-microglobulin | -0.0400213 |
| PLCB4 | phospholipase C, beta 4 | -0.0394353 |
| RTN4 | reticulon 4 | -0.0379645 |
| TMEM178B | transmembrane protein 178B | -0.0378578 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0374773 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0370614 |
| KPNB1 | karyopherin (importin) beta 1 | -0.035236 |
| TMEM41B | transmembrane protein 41B | -0.0346555 |
| HLA-A | major histocompatibility complex, class I, A | -0.0334218 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0333687 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0326454 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0320578 |
| PLIN2 | perilipin 2 | -0.0319635 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0319615 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0318366 |
| SLC12A8 | solute carrier family 12, member 8 | -0.031808 |
| MYL12B | myosin, light chain 12B, regulatory | -0.031495 |
| TMSB10 | thymosin beta 10 | -0.0295597 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.029399 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0289222 |
| LIMA1 | LIM domain and actin binding 1 | -0.0286282 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0282215 |
| IER3 | immediate early response 3 | -0.0278386 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0277889 |
| TGFB2 | transforming growth factor, beta 2 | -0.0275135 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0274897 |
| CTSD | cathepsin D | -0.0270271 |
| RPS8 | ribosomal protein S8 | -0.0267699 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.026215 |
| SNX4 | sorting nexin 4 | -0.0258221 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0256875 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0251931 |
| ATP13A3 | ATPase type 13A3 | -0.0249483 |
| SETD5 | SET domain containing 5 | -0.0248563 |
| PFN1 | profilin 1 | -0.0248233 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0244969 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0243848 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0243348 |
| RPLP2 | ribosomal protein, large, P2 | -0.0242579 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0242423 |
| GRAMD2B | GRAM domain containing 2B | -0.0240751 |
| ZNF292 | zinc finger protein 292 | -0.0239503 |
| TNPO1 | transportin 1 | -0.02389 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0236605 |
| USP3 | ubiquitin specific peptidase 3 | -0.0231686 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0229408 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0228657 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0228474 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0228465 |
| RPS24 | ribosomal protein S24 | -0.0226047 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0225973 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0225713 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.022561 |
| RPL23 | ribosomal protein L23 | -0.0225589 |
| MYLK | myosin light chain kinase | -0.0224588 |
| RNF144B | ring finger protein 144B | -0.0222877 |
| RAI1 | retinoic acid induced 1 | -0.0222134 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.022071 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0219326 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0218275 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0217301 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0215377 |
| SRPK2 | SRSF protein kinase 2 | -0.0214594 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0213945 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0213152 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0212524 |
| NUP214 | nucleoporin 214kDa | -0.0212437 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0211055 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | -0.0210332 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0209533 |
| CCDC14 | coiled-coil domain containing 14 | -0.0209261 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0208533 |
| RAB6A | RAB6A, member RAS oncogene family | -0.020715 |
| RUNX2 | runt-related transcription factor 2 | -0.020247 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0202437 |
