AZD-8055_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in KATO III cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the AZD-8055_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMC5 transmembrane channel-like 5 0.186164
LMO7 LIM domain 7 0.177251
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.164095
MBNL2 muscleblind-like splicing regulator 2 0.154746
EMP1 epithelial membrane protein 1 0.140599
TPT1 tumor protein, translationally-controlled 1 0.103024
FTL ferritin, light polypeptide 0.0882209
NDRG1 N-myc downstream regulated 1 0.0841353
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0750057
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0746119
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0731635
ANXA1 annexin A1 0.0719014
FTH1 ferritin, heavy polypeptide 1 0.0716518
RPS6 ribosomal protein S6 0.0713592
B2M beta-2-microglobulin 0.0679106
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0661926
AKAP13 A kinase (PRKA) anchor protein 13 0.0635864
FNDC3B fibronectin type III domain containing 3B 0.0614197
EIF1 eukaryotic translation initiation factor 1 0.0592045
MYOF myoferlin 0.0572296
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0564483
FRMD5 FERM domain containing 5 0.0553252
DSPP dentin sialophosphoprotein 0.0548731
EZR ezrin 0.0547909
PTPRK protein tyrosine phosphatase, receptor type, K 0.0528364
RPL26 ribosomal protein L26 0.0527664
AKAP9 A kinase (PRKA) anchor protein 9 0.0510427
NUPR1 nuclear protein, transcriptional regulator, 1 0.0501158
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.048186
DSG2 desmoglein 2 0.0480545
GOLGB1 golgin B1 0.0473923
MACC1 metastasis associated in colon cancer 1 0.0473326
DSTN destrin (actin depolymerizing factor) 0.0471841
TXNIP thioredoxin interacting protein 0.0455364
RPS25 ribosomal protein S25 0.0431787
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0425876
MYO1E myosin IE 0.041888
BACE2 beta-site APP-cleaving enzyme 2 0.040746
RPS12 ribosomal protein S12 0.0403806
DST dystonin 0.039726
TM4SF1 transmembrane 4 L six family member 1 0.0395547
MCU mitochondrial calcium uniporter 0.0394205
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0386893
KLF6 Kruppel-like factor 6 0.0385966
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0384584
AGR3 anterior gradient 3 0.0382547
RPS8 ribosomal protein S8 0.0375335
POF1B premature ovarian failure, 1B 0.0369709
UGCG UDP-glucose ceramide glucosyltransferase 0.0368123
GDA guanine deaminase 0.0367783
FGFR2 fibroblast growth factor receptor 2 0.0353951
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0345552
KLF5 Kruppel-like factor 5 (intestinal) 0.0342299
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0341776
HSPA8 heat shock 70kDa protein 8 0.0330676
RPL23 ribosomal protein L23 0.0323963
EXPH5 exophilin 5 0.0319301
HDAC9 histone deacetylase 9 0.0315564
EIF4A2 eukaryotic translation initiation factor 4A2 0.0312214
PHF3 PHD finger protein 3 0.0311361
FOXP1 forkhead box P1 0.0307409
SGMS2 sphingomyelin synthase 2 0.0306514
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0303703
TMEM45B transmembrane protein 45B 0.0296469
PDLIM5 PDZ and LIM domain 5 0.0294437
MYADM myeloid-associated differentiation marker 0.0292736
RASEF RAS and EF-hand domain containing 0.0286444
MUC17 mucin 17, cell surface associated 0.0274314
SEPTIN9 septin 9 0.0271668
SQSTM1 sequestosome 1 0.0269045
UBE2H ubiquitin-conjugating enzyme E2H 0.0265212
LPP LIM domain containing preferred translocation partner in lipoma 0.0262857
N4BP2L2 NEDD4 binding protein 2-like 2 0.0261816
RPS27 ribosomal protein S27 0.0258932
LCN2 lipocalin 2 0.0256694
RPS16 ribosomal protein S16 0.0255522
RPL19 ribosomal protein L19 0.0254333
RPL7 ribosomal protein L7 0.025415
PNRC1 proline-rich nuclear receptor coactivator 1 0.0252843
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0247431
ADAM28 ADAM metallopeptidase domain 28 0.0244982
RPS19 ribosomal protein S19 0.0244596
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0244318
SPATA13 spermatogenesis associated 13 0.0242011
DOCK5 dedicator of cytokinesis 5 0.0241942
FRY furry homolog (Drosophila) 0.0241535
UBC ubiquitin C 0.0241226
ZSWIM6 zinc finger, SWIM-type containing 6 0.0240717
KLHL24 kelch-like family member 24 0.0240025
RPS13 ribosomal protein S13 0.0239585
MBNL1 muscleblind-like splicing regulator 1 0.0238531
RPL34 ribosomal protein L34 0.0237413
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.0237395
RPS2 ribosomal protein S2 0.0236547
EXT1 exostosin glycosyltransferase 1 0.0234504
DYNLT3 dynein, light chain, Tctex-type 3 0.0233413
ANXA3 annexin A3 0.0233254
GOLGA4 golgin A4 0.0232956
LOC112694756 uncharaterized LOC112694756 0.0232561
ADGRF1 adhesion G protein-coupled receptor F1 0.0232119

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.220928
GMDS GDP-mannose 4,6-dehydratase -0.137697
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.112861
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107143
CEMIP cell migration inducing protein, hyaluronan binding -0.0980484
ANLN anillin, actin binding protein -0.0863525
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0756908
ITGA6 integrin, alpha 6 -0.0750807
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0729165
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0723179
SMC4 structural maintenance of chromosomes 4 -0.063152
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0586993
EHBP1 EH domain binding protein 1 -0.0582862
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0576406
FLNB filamin B, beta -0.0549087
PDIA3 protein disulfide isomerase family A, member 3 -0.0548538
MKI67 marker of proliferation Ki-67 -0.0515386
ECT2 epithelial cell transforming 2 -0.0511737
DIAPH3 diaphanous-related formin 3 -0.0506139
DLG1 discs, large homolog 1 (Drosophila) -0.0504767
ACACA acetyl-CoA carboxylase alpha -0.0498237
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0493649
TFRC transferrin receptor -0.0491242
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0453385
INSIG1 insulin induced gene 1 -0.0451218
ANKRD11 ankyrin repeat domain 11 -0.0445848
CTBP2 C-terminal binding protein 2 -0.0436133
ANO1 anoctamin 1, calcium activated chloride channel -0.0431658
KRT8 keratin 8, type II -0.0427948
RRM2 ribonucleotide reductase M2 -0.0411143
RRBP1 ribosome binding protein 1 -0.0400838
IARS1 isoleucyl-tRNA synthetase 1 -0.0389947
BIRC6 baculoviral IAP repeat containing 6 -0.0379062
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0378557
PTMA prothymosin, alpha -0.0368065
HYOU1 hypoxia up-regulated 1 -0.0367681
CD46 CD46 molecule, complement regulatory protein -0.0363427
NHSL1 NHS-like 1 -0.0362447
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0358501
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0357042
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0355574
ANXA2 annexin A2 -0.0355101
RNF43 ring finger protein 43 -0.0350837
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0348891
FAT1 FAT atypical cadherin 1 -0.034019
PDIA4 protein disulfide isomerase family A, member 4 -0.0338872
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0338767
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0337171
XPO1 exportin 1 -0.0330088
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0327352
CAMKMT calmodulin-lysine N-methyltransferase -0.0327195
GSK3B glycogen synthase kinase 3 beta -0.0323556
GPHN gephyrin -0.0323301
GNAS GNAS complex locus -0.0322478
DEK DEK proto-oncogene -0.0321325
S100A10 S100 calcium binding protein A10 -0.0317651
ATAD2 ATPase family, AAA domain containing 2 -0.0317598
ZFAND3 zinc finger, AN1-type domain 3 -0.0315187
SRPK2 SRSF protein kinase 2 -0.0314428
PRKCA protein kinase C, alpha -0.0311235
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0310464
GARS1 glycyl-tRNA synthetase 1 -0.0308529
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.030615
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0305406
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0302149
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0299533
KPNB1 karyopherin (importin) beta 1 -0.0296055
PDIA6 protein disulfide isomerase family A, member 6 -0.0294425
ADIPOR2 adiponectin receptor 2 -0.029433
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0289879
SAMD12 sterile alpha motif domain containing 12 -0.0289736
TPX2 TPX2, microtubule-associated -0.0286562
BRCA1 breast cancer 1, early onset -0.0284777
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0283539
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0279129
RBM25 RNA binding motif protein 25 -0.0279101
MECOM MDS1 and EVI1 complex locus -0.0278691
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.027781
ACTN4 actinin, alpha 4 -0.027641
LPIN1 lipin 1 -0.0275199
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0273867
FBXO11 F-box protein 11 -0.0273763
FANCI Fanconi anemia, complementation group I -0.0273719
SMC1A structural maintenance of chromosomes 1A -0.0273205
H1-0 H1.0 linker histone -0.0270814
ZMYM2 zinc finger, MYM-type 2 -0.0269257
TMEM135 transmembrane protein 135 -0.0268573
AHNAK AHNAK nucleoprotein -0.026628
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0263996
CENPP centromere protein P -0.0263055
CCNL1 cyclin L1 -0.0261029
ZC3H12B zinc finger CCCH-type containing 12B -0.0260097
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.025973
THOC2 THO complex 2 -0.0258992
SREBF2 sterol regulatory element binding transcription factor 2 -0.0256677
NSD2 nuclear receptor binding SET domain protein 2 -0.0253108
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.025147
YAP1 Yes-associated protein 1 -0.0247453
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0246898
RTN4 reticulon 4 -0.0242218