AZD-8055_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.144647
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.095914
AFF1 AF4/FMR2 family, member 1 0.0859669
HSPA8 heat shock 70kDa protein 8 0.0848279
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0837464
RPS2 ribosomal protein S2 0.072958
FAT1 FAT atypical cadherin 1 0.0603153
TXNIP thioredoxin interacting protein 0.057355
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0565545
NEBL nebulette 0.055347
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0534638
MBNL2 muscleblind-like splicing regulator 2 0.0521436
GOLGA4 golgin A4 0.0501547
TGFBR3 transforming growth factor, beta receptor III 0.0500315
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0493829
PABPC1 poly(A) binding protein, cytoplasmic 1 0.048819
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0475245
NDRG1 N-myc downstream regulated 1 0.0472698
RPS6 ribosomal protein S6 0.0467979
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0466408
EEF2 eukaryotic translation elongation factor 2 0.0455327
MYO1E myosin IE 0.0450273
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0446057
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0444857
EXT1 exostosin glycosyltransferase 1 0.0435017
DSG2 desmoglein 2 0.042431
UNC13B unc-13 homolog B (C. elegans) 0.042421
H1-0 H1.0 linker histone 0.0418756
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.040883
WHRN whirlin 0.040705
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.039999
EIF1 eukaryotic translation initiation factor 1 0.0393715
RPL3 ribosomal protein L3 0.0392152
ANXA1 annexin A1 0.0378757
DSPP dentin sialophosphoprotein 0.036928
VEGFA vascular endothelial growth factor A 0.0356896
UBC ubiquitin C 0.0349979
FTH1 ferritin, heavy polypeptide 1 0.0336435
MARCHF3 membrane associated ring-CH-type finger 3 0.033046
RPS18 ribosomal protein S18 0.032379
RPL7 ribosomal protein L7 0.0323722
RPLP0 ribosomal protein, large, P0 0.0313476
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0313308
RPS12 ribosomal protein S12 0.0312112
TPT1 tumor protein, translationally-controlled 1 0.0299473
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0293556
TMF1 TATA element modulatory factor 1 0.0291914
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0289514
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0288789
KTN1 kinectin 1 (kinesin receptor) 0.0285634
LDHA lactate dehydrogenase A 0.0284189
EXPH5 exophilin 5 0.0283762
GOLGB1 golgin B1 0.0279867
RPL12 ribosomal protein L12 0.0276665
CRY1 cryptochrome circadian clock 1 0.0271219
PDZD8 PDZ domain containing 8 0.0266307
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0265832
TPD52 tumor protein D52 0.026406
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0262911
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0262698
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0260773
BRD2 bromodomain containing 2 0.0259896
ERRFI1 ERBB receptor feedback inhibitor 1 0.0255096
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0253932
SLC38A2 solute carrier family 38, member 2 0.0245003
PNRC1 proline-rich nuclear receptor coactivator 1 0.0241412
B2M beta-2-microglobulin 0.0238279
TRAM1 translocation associated membrane protein 1 0.0237865
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0237502
FBXO32 F-box protein 32 0.0233891
ARHGAP21 Rho GTPase activating protein 21 0.0233193
ARHGAP42 Rho GTPase activating protein 42 0.0232094
UBN2 ubinuclein 2 0.0230829
P4HB prolyl 4-hydroxylase, beta polypeptide 0.023082
EIF4A2 eukaryotic translation initiation factor 4A2 0.0227528
MACF1 microtubule-actin crosslinking factor 1 0.0227013
PAPOLA poly(A) polymerase alpha 0.0226228
MLF1 myeloid leukemia factor 1 0.0225038
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0224934
CANX calnexin 0.0224369
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0223594
JMY junction mediating and regulatory protein, p53 cofactor 0.0217783
TTC3 tetratricopeptide repeat domain 3 0.0217712
SPON1 spondin 1, extracellular matrix protein 0.0217409
EREG epiregulin 0.0216464
ATXN1 ataxin 1 0.0215603
RPS8 ribosomal protein S8 0.0213677
LGALS3 lectin, galactoside-binding, soluble, 3 0.0213564
BTBD9 BTB (POZ) domain containing 9 0.0211928
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0211909
RPL26 ribosomal protein L26 0.0210686
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0209197
CLIP2 CAP-GLY domain containing linker protein 2 0.0206853
EGFR epidermal growth factor receptor 0.0204153
RPL15 ribosomal protein L15 0.0201298
ABHD2 abhydrolase domain containing 2 0.0200397
CLCN3 chloride channel, voltage-sensitive 3 0.0199667
RIGI RNA sensor RIG-I 0.0199126
RORA RAR-related orphan receptor A 0.0198529
ATF3 activating transcription factor 3 0.0198399

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.312202
VCL vinculin -0.152471
CEMIP cell migration inducing protein, hyaluronan binding -0.132257
NALF1 NALCN channel auxiliary factor 1 -0.132067
PTMA prothymosin, alpha -0.121508
FLNB filamin B, beta -0.107609
GPHN gephyrin -0.0975104
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0915033
TMSB10 thymosin beta 10 -0.0902659
ANXA2 annexin A2 -0.0889717
PRELID2 PRELI domain containing 2 -0.0772472
ACTN4 actinin, alpha 4 -0.0752626
ALCAM activated leukocyte cell adhesion molecule -0.0732853
FHIT fragile histidine triad -0.0715143
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0694509
AHNAK AHNAK nucleoprotein -0.0681177
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0671023
RNF43 ring finger protein 43 -0.0664167
TNS4 tensin 4 -0.065121
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0645402
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0643604
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0614726
GMDS GDP-mannose 4,6-dehydratase -0.0608557
ITGA6 integrin, alpha 6 -0.0581946
TRIO trio Rho guanine nucleotide exchange factor -0.0545686
CADPS Ca++-dependent secretion activator -0.0543969
GREB1L growth regulation by estrogen in breast cancer-like -0.0542945
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0519916
SLC35F3 solute carrier family 35, member F3 -0.0516254
ASPH aspartate beta-hydroxylase -0.0492358
RNF217 ring finger protein 217 -0.048924
ONECUT3 one cut homeobox 3 -0.0489016
MAML2 mastermind-like 2 (Drosophila) -0.0485773
DENND1A DENN/MADD domain containing 1A -0.04856
CD46 CD46 molecule, complement regulatory protein -0.048365
EHBP1 EH domain binding protein 1 -0.0482246
RAD51B RAD51 paralog B -0.047901
ARHGAP26 Rho GTPase activating protein 26 -0.0460438
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0450442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0448297
IER3 immediate early response 3 -0.0448167
ACTG1 actin gamma 1 -0.0427225
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0421136
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0413099
LAMA4 laminin, alpha 4 -0.0409489
MSI2 musashi RNA-binding protein 2 -0.0409294
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0399056
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0394973
PALLD palladin, cytoskeletal associated protein -0.0387749
PSD3 pleckstrin and Sec7 domain containing 3 -0.0384405
KRT8 keratin 8, type II -0.0384088
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0381141
PNISR PNN-interacting serine/arginine-rich protein -0.0378867
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0375609
DLG1 discs, large homolog 1 (Drosophila) -0.0374291
PRSS3 protease, serine, 3 -0.0372465
F3 coagulation factor III (thromboplastin, tissue factor) -0.0370516
MYH9 myosin, heavy chain 9, non-muscle -0.0370147
RAB10 RAB10, member RAS oncogene family -0.0367505
LPP LIM domain containing preferred translocation partner in lipoma -0.0367121
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0365188
LSAMP limbic system-associated membrane protein -0.0365066
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0363755
RIN2 Ras and Rab interactor 2 -0.0360957
MECOM MDS1 and EVI1 complex locus -0.0360275
ECT2 epithelial cell transforming 2 -0.0352502
ARHGAP32 Rho GTPase activating protein 32 -0.0351289
DIAPH3 diaphanous-related formin 3 -0.0349525
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0347892
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0346458
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.033829
ANKRD10 ankyrin repeat domain 10 -0.0332869
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0324067
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0320528
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0317397
PTPRK protein tyrosine phosphatase, receptor type, K -0.0317195
CCSER1 coiled-coil serine-rich protein 1 -0.0315067
SMYD3 SET and MYND domain containing 3 -0.0313979
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0311282
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0310262
CALB1 calbindin 1, 28kDa -0.0308267
CTBP2 C-terminal binding protein 2 -0.0306536
MBD5 methyl-CpG binding domain protein 5 -0.030567
MED13L mediator complex subunit 13-like -0.0297284
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0294591
DIAPH2 diaphanous-related formin 2 -0.029458
TBC1D22A TBC1 domain family, member 22A -0.0294557
TBC1D5 TBC1 domain family, member 5 -0.0293434
PGK1 phosphoglycerate kinase 1 -0.0290046
ABR active BCR-related -0.0289181
ETV6 ets variant 6 -0.0288375
PKM pyruvate kinase, muscle -0.02869
POU2F1 POU class 2 homeobox 1 -0.028318
SERINC5 serine incorporator 5 -0.0282896
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0282375
EXOC4 exocyst complex component 4 -0.0282308
GPR39 G protein-coupled receptor 39 -0.0280681
PKP2 plakophilin 2 -0.0275789
GCC2 GRIP and coiled-coil domain containing 2 -0.027281
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0271388