AZD-8055_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.169246
EPS8 epidermal growth factor receptor pathway substrate 8 0.0853829
FAT1 FAT atypical cadherin 1 0.0734452
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0733117
LMO7 LIM domain 7 0.0715224
FLNB filamin B, beta 0.0644927
SHROOM3 shroom family member 3 0.0622434
ESYT2 extended synaptotagmin-like protein 2 0.061378
HSPA8 heat shock 70kDa protein 8 0.0588792
DSPP dentin sialophosphoprotein 0.0579281
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0539005
EGFR epidermal growth factor receptor 0.0524779
RPL3 ribosomal protein L3 0.0501516
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0475825
TXNRD1 thioredoxin reductase 1 0.0450854
SLTM SAFB-like, transcription modulator 0.0436505
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0433489
AKAP13 A kinase (PRKA) anchor protein 13 0.04298
RPS2 ribosomal protein S2 0.0404142
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.039977
ANO6 anoctamin 6 0.039288
CALB1 calbindin 1, 28kDa 0.0391424
RPS18 ribosomal protein S18 0.039106
PRRC2C proline-rich coiled-coil 2C 0.0390766
DSCAM Down syndrome cell adhesion molecule 0.0386948
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0380775
ERBIN erbb2 interacting protein 0.0379209
KDM7A lysine (K)-specific demethylase 7A 0.037727
KMT2C lysine (K)-specific methyltransferase 2C 0.0368979
ITGA6 integrin, alpha 6 0.0354438
MED13L mediator complex subunit 13-like 0.0351711
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0347687
ARRDC3 arrestin domain containing 3 0.033986
CEMIP cell migration inducing protein, hyaluronan binding 0.0338403
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0337389
UTRN utrophin 0.033499
MYOF myoferlin 0.0334252
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.033332
MACF1 microtubule-actin crosslinking factor 1 0.0332417
PCBP2 poly(rC) binding protein 2 0.0325599
THSD4 thrombospondin, type I, domain containing 4 0.0325087
SLMAP sarcolemma associated protein 0.0313443
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0312066
GOLGA4 golgin A4 0.0310418
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0303824
MYO6 myosin VI 0.030311
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0301989
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.030188
DSG2 desmoglein 2 0.0291527
NCKAP1 NCK-associated protein 1 0.0288933
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0286836
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0286694
MYH9 myosin, heavy chain 9, non-muscle 0.0285677
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0283925
PDZD8 PDZ domain containing 8 0.0279846
CHD1 chromodomain helicase DNA binding protein 1 0.0277872
ZFAND3 zinc finger, AN1-type domain 3 0.0276271
PRSS3 protease, serine, 3 0.0275147
AHCYL2 adenosylhomocysteinase-like 2 0.0273748
ZFC3H1 zinc finger, C3H1-type containing 0.0271588
PARD3B par-3 family cell polarity regulator beta 0.02681
USP3 ubiquitin specific peptidase 3 0.0267213
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0266233
POTEF POTE ankyrin domain family, member F 0.026419
PDE8A phosphodiesterase 8A 0.0264162
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0262072
TJP1 tight junction protein 1 0.0262018
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0258113
SMAD3 SMAD family member 3 0.0256857
MPRIP myosin phosphatase Rho interacting protein 0.0256533
RPL21 ribosomal protein L21 0.025629
IQGAP1 IQ motif containing GTPase activating protein 1 0.0241424
MUC13 mucin 13, cell surface associated 0.0240445
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0240329
RREB1 ras responsive element binding protein 1 0.023911
RNF145 ring finger protein 145 0.0238691
LAMC2 laminin, gamma 2 0.0237521
ANTXR2 anthrax toxin receptor 2 0.0237386
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0235279
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.023431
EIF4A2 eukaryotic translation initiation factor 4A2 0.0232179
CLTC clathrin, heavy chain (Hc) 0.0231885
KIF5B kinesin family member 5B 0.0230807
DOCK5 dedicator of cytokinesis 5 0.0228512
OXSR1 oxidative stress responsive 1 0.0228003
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0227515
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0226969
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226867
PTPRG protein tyrosine phosphatase, receptor type, G 0.0225303
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0224938
IFNGR1 interferon gamma receptor 1 0.0224387
RAP1B RAP1B, member of RAS oncogene family 0.0224097
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0223991
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0222455
UBE2H ubiquitin-conjugating enzyme E2H 0.0222448
PLSCR1 phospholipid scramblase 1 0.022157
BRD2 bromodomain containing 2 0.0219731
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0219648
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0218918
USP34 ubiquitin specific peptidase 34 0.0218696

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.178736
RPS6 ribosomal protein S6 -0.156472
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.131521
RPS8 ribosomal protein S8 -0.129745
RPLP1 ribosomal protein, large, P1 -0.125691
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.114365
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.11037
RPL37A ribosomal protein L37a -0.0900135
PTMA prothymosin, alpha -0.0858543
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0828044
RPS3 ribosomal protein S3 -0.0797635
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0775011
RPS12 ribosomal protein S12 -0.0773489
RPS25 ribosomal protein S25 -0.0733935
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0732337
RPS19 ribosomal protein S19 -0.073153
RPL31 ribosomal protein L31 -0.0722747
RPL35A ribosomal protein L35a -0.070829
VCL vinculin -0.0701642
RPS29 ribosomal protein S29 -0.0694278
F3 coagulation factor III (thromboplastin, tissue factor) -0.0638167
RPLP2 ribosomal protein, large, P2 -0.0634193
NPSR1 neuropeptide S receptor 1 -0.0630454
RPS24 ribosomal protein S24 -0.0628436
RPS27A ribosomal protein S27a -0.0549925
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0540173
GMDS GDP-mannose 4,6-dehydratase -0.0538969
RPL34 ribosomal protein L34 -0.0521167
RPL23 ribosomal protein L23 -0.0501408
RPS13 ribosomal protein S13 -0.0482526
RPL9 ribosomal protein L9 -0.047681
RPL37 ribosomal protein L37 -0.0470151
RPS17 ribosomal protein S17 -0.0467568
RPS16 ribosomal protein S16 -0.0462182
AGR2 anterior gradient 2 -0.046165
RPL26 ribosomal protein L26 -0.0435414
RPL19 ribosomal protein L19 -0.0434997
RPLP0 ribosomal protein, large, P0 -0.0427471
RPS27 ribosomal protein S27 -0.0424706
PALLD palladin, cytoskeletal associated protein -0.0404436
TMSB10 thymosin beta 10 -0.0400523
PDIA3 protein disulfide isomerase family A, member 3 -0.0384401
ANXA2 annexin A2 -0.0378099
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0374087
RPL7A ribosomal protein L7a -0.0370001
RACK1 receptor for activated C kinase 1 -0.0368622
RPS14 ribosomal protein S14 -0.0367599
RPS20 ribosomal protein S20 -0.036564
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0354791
RPL38 ribosomal protein L38 -0.0353687
RPS23 ribosomal protein S23 -0.0351299
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0350428
IFI6 interferon, alpha-inducible protein 6 -0.0348634
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.0338529
RPL8 ribosomal protein L8 -0.033063
ACTN4 actinin, alpha 4 -0.0322071
EGR1 early growth response 1 -0.0319973
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.03195
FTL ferritin, light polypeptide -0.0318904
ALCAM activated leukocyte cell adhesion molecule -0.0316669
MYH14 myosin, heavy chain 14, non-muscle -0.0315298
ACTG1 actin gamma 1 -0.0311225
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0305163
TPM4 tropomyosin 4 -0.0304939
RPL27A ribosomal protein L27a -0.0301243
IER3 immediate early response 3 -0.0298106
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0296629
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0294983
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0291686
PTPRB protein tyrosine phosphatase, receptor type, B -0.0284374
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0281144
HLA-B major histocompatibility complex, class I, B -0.0272171
KRT18 keratin 18, type I -0.0267674
PKM pyruvate kinase, muscle -0.0266712
RPS11 ribosomal protein S11 -0.0266488
CLDN4 claudin 4 -0.0253385
SQSTM1 sequestosome 1 -0.0252403
CD9 CD9 molecule -0.0249519
RPL36 ribosomal protein L36 -0.0248948
RPL10A ribosomal protein L10a -0.0248507
RPL28 ribosomal protein L28 -0.024507
RPL30 ribosomal protein L30 -0.0242899
KRT8 keratin 8, type II -0.0242654
RPL5 ribosomal protein L5 -0.0241116
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0239165
GNAS GNAS complex locus -0.023704
PDLIM5 PDZ and LIM domain 5 -0.0236348
NOP53 NOP53 ribosome biogenesis factor -0.0233456
LOC102724023 ES1 protein homolog, mitochondrial -0.0233223
RPL11 ribosomal protein L11 -0.0232971
RPS5 ribosomal protein S5 -0.0231379
TBCA tubulin folding cofactor A -0.0231127
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0225743
RPL35 ribosomal protein L35 -0.0224268
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0221935
MYO1E myosin IE -0.0217811
RPL12 ribosomal protein L12 -0.0217294
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0216285
TPM1 tropomyosin 1 (alpha) -0.0213234
AOPEP aminopeptidase O (putative) -0.0212784