| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.149016 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.116372 |
| TXNRD1 | thioredoxin reductase 1 | 0.105279 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0837139 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0824769 |
| FMNL2 | formin-like 2 | 0.0807423 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0788994 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0670755 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0636305 |
| CAPRIN2 | caprin family member 2 | 0.0634003 |
| EMP1 | epithelial membrane protein 1 | 0.062021 |
| DST | dystonin | 0.0617089 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0589503 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0570918 |
| EZR | ezrin | 0.0547959 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0530496 |
| JMJD1C | jumonji domain containing 1C | 0.0520089 |
| SPAG9 | sperm associated antigen 9 | 0.0513464 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0490948 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0487871 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0479286 |
| RPS2 | ribosomal protein S2 | 0.0478141 |
| APP | amyloid beta (A4) precursor protein | 0.0474805 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0470742 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0452177 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0440436 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0405099 |
| RUNX1 | runt-related transcription factor 1 | 0.0401564 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0381189 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0380695 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0364955 |
| EREG | epiregulin | 0.0362464 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0357607 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.035428 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0352764 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.034734 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.034178 |
| COL5A2 | collagen, type V, alpha 2 | 0.0336594 |
| PYGL | phosphorylase, glycogen, liver | 0.0331315 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0329334 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0326025 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0325993 |
| YBX3 | Y box binding protein 3 | 0.0325056 |
| RPS6 | ribosomal protein S6 | 0.0319827 |
| ANXA1 | annexin A1 | 0.0316193 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0312923 |
| RPS18 | ribosomal protein S18 | 0.0312504 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0310076 |
| PODXL | podocalyxin-like | 0.0306933 |
| GOLGB1 | golgin B1 | 0.0304138 |
| SET | SET nuclear proto-oncogene | 0.03039 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0301002 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0299481 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0298745 |
| POTEF | POTE ankyrin domain family, member F | 0.0295508 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0294312 |
| KLF6 | Kruppel-like factor 6 | 0.029423 |
| CDCP1 | CUB domain containing protein 1 | 0.0291311 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.028629 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.028552 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0285422 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0280186 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0276491 |
| CLTC | clathrin, heavy chain (Hc) | 0.0274721 |
| CEP170 | centrosomal protein 170kDa | 0.0274634 |
| RAI1 | retinoic acid induced 1 | 0.0266068 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.026507 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0264986 |
| VEGFC | vascular endothelial growth factor C | 0.0264338 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0263723 |
| PDE10A | phosphodiesterase 10A | 0.0262807 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0257129 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0256863 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0254787 |
| MATR3 | matrin 3 | 0.0254019 |
| DNER | delta/notch-like EGF repeat containing | 0.0251601 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0248741 |
| IPO7 | importin 7 | 0.0248241 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.024508 |
| PCBP2 | poly(rC) binding protein 2 | 0.0242463 |
| ADAR | adenosine deaminase, RNA-specific | 0.0241117 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0237931 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0237794 |
| PLK2 | polo-like kinase 2 | 0.0235981 |
| PYGB | phosphorylase, glycogen; brain | 0.0235834 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0233059 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0232149 |
| XPO1 | exportin 1 | 0.0230848 |
| SON | SON DNA binding protein | 0.0229603 |
| RLF | rearranged L-myc fusion | 0.0229166 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0226147 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0225095 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0223184 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0222701 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0222179 |
| H1-0 | H1.0 linker histone | 0.0221408 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0221074 |
| PAPOLA | poly(A) polymerase alpha | 0.0220399 |
| MYO9B | myosin IXB | 0.0218948 |
| VMP1 | vacuole membrane protein 1 | 0.0215226 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.109883 |
| VIM | vimentin | -0.094403 |
| TMSB10 | thymosin beta 10 | -0.0854738 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0817935 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0749058 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0718012 |
| HLA-B | major histocompatibility complex, class I, B | -0.0695463 |
| RPL35A | ribosomal protein L35a | -0.056625 |
| RIGI | RNA sensor RIG-I | -0.0404721 |
| VCL | vinculin | -0.0398005 |
| TMSB4X | thymosin beta 4, X-linked | -0.0393081 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0378315 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0354158 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0341398 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0328853 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0315055 |
| EHBP1 | EH domain binding protein 1 | -0.0312193 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0310174 |
| EGR1 | early growth response 1 | -0.0298507 |
| EPHA4 | EPH receptor A4 | -0.0297474 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0291116 |
| LRRC49 | leucine rich repeat containing 49 | -0.0283638 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0280984 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0277676 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0272757 |
| RPS24 | ribosomal protein S24 | -0.0268437 |
| MYOF | myoferlin | -0.0264997 |
| SP100 | SP100 nuclear antigen | -0.0262161 |
| EGFR | epidermal growth factor receptor | -0.0260441 |
| GNAS | GNAS complex locus | -0.0244684 |
| PRELID2 | PRELI domain containing 2 | -0.0244663 |
| HDAC9 | histone deacetylase 9 | -0.0242014 |
| INTS6 | integrator complex subunit 6 | -0.023673 |
| EFNA5 | ephrin-A5 | -0.0234254 |
| PLSCR1 | phospholipid scramblase 1 | -0.0232786 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0231545 |
| SRGN | serglycin | -0.0229428 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0228283 |
| RAD51B | RAD51 paralog B | -0.0226382 |
| STK17A | serine/threonine kinase 17a | -0.0215805 |
| CD44 | CD44 molecule (Indian blood group) | -0.0213077 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0212827 |
| OSMR | oncostatin M receptor | -0.0209865 |
| AEBP2 | AE binding protein 2 | -0.0209567 |
| S100A9 | S100 calcium binding protein A9 | -0.0207415 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0207376 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0203048 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0196943 |
| TNS3 | tensin 3 | -0.0191892 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0191471 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0191167 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0189621 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0187327 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0185683 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.0184329 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0183449 |
| RPL34 | ribosomal protein L34 | -0.018294 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0181047 |
| HLA-A | major histocompatibility complex, class I, A | -0.018073 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0179722 |
| PMP22 | peripheral myelin protein 22 | -0.017939 |
| TGM2 | transglutaminase 2 | -0.0171058 |
| CADM2 | cell adhesion molecule 2 | -0.0166507 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.016523 |
| RNF213 | ring finger protein 213 | -0.0163562 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0161423 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0157633 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0156308 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0153429 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0152041 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0146634 |
| CAVIN1 | caveolae associated protein 1 | -0.0144208 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0143623 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0136265 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0135444 |
| S100A10 | S100 calcium binding protein A10 | -0.0134627 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0132702 |
| RPS28 | ribosomal protein S28 | -0.0131715 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0130004 |
| RPL9 | ribosomal protein L9 | -0.0129759 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0129332 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.012879 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0128379 |
| CD109 | CD109 molecule | -0.0127231 |
| SMIM44 | small integral membrane protein 44 | -0.0127105 |
| CCDC91 | coiled-coil domain containing 91 | -0.0126616 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0126016 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0125648 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0125357 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0125311 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0124374 |
| RPS27A | ribosomal protein S27a | -0.0123739 |
| TBCA | tubulin folding cofactor A | -0.0123703 |
| FBXO11 | F-box protein 11 | -0.0123435 |
| CCND1 | cyclin D1 | -0.0120114 |
| HMGB1 | high mobility group box 1 | -0.011941 |
| ANXA2 | annexin A2 | -0.011836 |
| ACTG1 | actin gamma 1 | -0.0118125 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0117815 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0116921 |
