| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-8055_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.225324 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.193733 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.11901 |
| EGFR | epidermal growth factor receptor | 0.102774 |
| SLTM | SAFB-like, transcription modulator | 0.0968841 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0903884 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0811615 |
| NDRG1 | N-myc downstream regulated 1 | 0.0727581 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0637756 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0614201 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0600141 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0546212 |
| STC1 | stanniocalcin 1 | 0.0539918 |
| FAM13A | family with sequence similarity 13, member A | 0.052203 |
| CDCP1 | CUB domain containing protein 1 | 0.0483292 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0477429 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0477267 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0476092 |
| CES1 | carboxylesterase 1 | 0.0434292 |
| SPAG9 | sperm associated antigen 9 | 0.0420514 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0405176 |
| PCBP2 | poly(rC) binding protein 2 | 0.0397706 |
| FNIP1 | folliculin interacting protein 1 | 0.0393958 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0382123 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0362855 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0360792 |
| ARRDC3 | arrestin domain containing 3 | 0.035255 |
| RPS2 | ribosomal protein S2 | 0.0340616 |
| UBC | ubiquitin C | 0.0318988 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0313494 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.030708 |
| NGLY1 | N-glycanase 1 | 0.0301588 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0290444 |
| GOLGB1 | golgin B1 | 0.0288913 |
| SNX9 | sorting nexin 9 | 0.0285055 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0284542 |
| TXNRD1 | thioredoxin reductase 1 | 0.0284055 |
| CD163L1 | CD163 molecule-like 1 | 0.028157 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0279159 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0277947 |
| YBX3 | Y box binding protein 3 | 0.0276787 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0272292 |
| RPS3 | ribosomal protein S3 | 0.0271803 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0270101 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0260552 |
| TPD52 | tumor protein D52 | 0.0257925 |
| CANX | calnexin | 0.0257607 |
| RPL7 | ribosomal protein L7 | 0.0257606 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0255064 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0252364 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0250376 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0248367 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0247949 |
| LYST | lysosomal trafficking regulator | 0.0247374 |
| HBP1 | HMG-box transcription factor 1 | 0.0244145 |
| CSTB | cystatin B (stefin B) | 0.0238465 |
| RUNX1 | runt-related transcription factor 1 | 0.023507 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0234649 |
| PAPOLA | poly(A) polymerase alpha | 0.0233508 |
| RPLP0 | ribosomal protein, large, P0 | 0.0232095 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0220734 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0218312 |
| LAMB3 | laminin, beta 3 | 0.0217899 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0214325 |
| ZNF292 | zinc finger protein 292 | 0.0209657 |
| LDAF1 | lipid droplet assembly factor 1 | 0.0208675 |
| UVRAG | UV radiation resistance associated | 0.0206973 |
| RPL3 | ribosomal protein L3 | 0.0203089 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0200126 |
| TMF1 | TATA element modulatory factor 1 | 0.0199977 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.019899 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0198204 |
| ADAR | adenosine deaminase, RNA-specific | 0.0194541 |
| ANO6 | anoctamin 6 | 0.019395 |
| RACK1 | receptor for activated C kinase 1 | 0.0192932 |
| RPS6 | ribosomal protein S6 | 0.0191329 |
| DSPP | dentin sialophosphoprotein | 0.0190783 |
| CUL4A | cullin 4A | 0.0186997 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0184967 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0182727 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0181193 |
| JMJD1C | jumonji domain containing 1C | 0.0180987 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0180171 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0179843 |
| SQSTM1 | sequestosome 1 | 0.0177638 |
| NCKAP1 | NCK-associated protein 1 | 0.0175653 |
| B2M | beta-2-microglobulin | 0.0173636 |
| CHMP1B | charged multivesicular body protein 1B | 0.0171373 |
| RESF1 | retroelement silencing factor 1 | 0.0171208 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | 0.017001 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0167867 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0167832 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0167065 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0166272 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0166006 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0165584 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0165526 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0164969 |
| MLF1 | myeloid leukemia factor 1 | 0.0164541 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0163571 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | -0.171809 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.158491 |
| TMSB10 | thymosin beta 10 | -0.113825 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0879317 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0841589 |
| VCL | vinculin | -0.0781427 |
| INTS6 | integrator complex subunit 6 | -0.0753307 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0694914 |
| EFNA5 | ephrin-A5 | -0.0669092 |
| NABP1 | nucleic acid binding protein 1 | -0.0626067 |
| SCEL | sciellin | -0.0619339 |
| ACTG1 | actin gamma 1 | -0.0590188 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0587539 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0521551 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0507509 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0506901 |
| GRAMD1B | GRAM domain containing 1B | -0.0490862 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0478489 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0477415 |
| ANXA2 | annexin A2 | -0.0457501 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0453586 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0430048 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0418137 |
| OSMR | oncostatin M receptor | -0.0394402 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0394308 |
| AHNAK | AHNAK nucleoprotein | -0.0385758 |
| PRKCA | protein kinase C, alpha | -0.0377825 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0377683 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0354657 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0353799 |
| CCND1 | cyclin D1 | -0.0349818 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0349568 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0348075 |
| EGR1 | early growth response 1 | -0.0346854 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.034449 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0343821 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0342459 |
| PTMA | prothymosin, alpha | -0.0337989 |
| KRT8 | keratin 8, type II | -0.0337147 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0335637 |
| CUX1 | cut-like homeobox 1 | -0.033189 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0331776 |
| FLNB | filamin B, beta | -0.0330576 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.031163 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0300743 |
| LAMA4 | laminin, alpha 4 | -0.0290972 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0289928 |
| TNS3 | tensin 3 | -0.028302 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0281481 |
| FBXO11 | F-box protein 11 | -0.0280892 |
| CMIP | c-Maf inducing protein | -0.0269561 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.026845 |
| LMO7 | LIM domain 7 | -0.0266643 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0266002 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0263367 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.026336 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0262346 |
| AREG | amphiregulin | -0.0256045 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0255183 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0253444 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0252262 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0248837 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0248142 |
| CTBP2 | C-terminal binding protein 2 | -0.0241678 |
| CST3 | cystatin C | -0.0238898 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0237247 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0236636 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0236412 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0235433 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0234036 |
| RIN2 | Ras and Rab interactor 2 | -0.0228759 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0227797 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0223796 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0222985 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0222924 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0222465 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0220893 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0217972 |
| RPL35A | ribosomal protein L35a | -0.0217259 |
| PCED1B | PC-esterase domain containing 1B | -0.0216349 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0216314 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0213156 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0208845 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0207061 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.02058 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0205229 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0204508 |
| FUS | FUS RNA binding protein | -0.0203566 |
| KRT7 | keratin 7, type II | -0.0203514 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0202605 |
| S100A10 | S100 calcium binding protein A10 | -0.0201238 |
| RCOR1 | REST corepressor 1 | -0.0200761 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0200071 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0199787 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0197684 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.019742 |
| EHBP1 | EH domain binding protein 1 | -0.0195442 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0194982 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0191028 |
| ZNF609 | zinc finger protein 609 | -0.019089 |
