AZD-8055_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.171526
CDH13 cadherin 13 0.117267
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.114941
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.113102
SDK1 sidekick cell adhesion molecule 1 0.112469
HMGA2 high mobility group AT-hook 2 0.105133
EFNA5 ephrin-A5 0.104098
FNDC3B fibronectin type III domain containing 3B 0.0968384
NAV2 neuron navigator 2 0.0942268
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0934635
AKAP12 A kinase (PRKA) anchor protein 12 0.091578
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0836088
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0834453
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0796535
SOD2 superoxide dismutase 2, mitochondrial 0.0748626
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.074176
CD44 CD44 molecule (Indian blood group) 0.0667843
DOCK5 dedicator of cytokinesis 5 0.0666514
ANTXR2 anthrax toxin receptor 2 0.0665302
USP34 ubiquitin specific peptidase 34 0.0614014
SMAD3 SMAD family member 3 0.0609207
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0603188
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0585578
NRG1 neuregulin 1 0.0582675
MTSS1 metastasis suppressor 1 0.057912
GRB10 growth factor receptor-bound protein 10 0.055578
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0547042
MACF1 microtubule-actin crosslinking factor 1 0.0521763
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0517028
FAM20C family with sequence similarity 20, member C 0.0513134
RAD51B RAD51 paralog B 0.049552
RAI14 retinoic acid induced 14 0.0490461
MSRB3 methionine sulfoxide reductase B3 0.0490322
EGFR epidermal growth factor receptor 0.0482473
CDCP1 CUB domain containing protein 1 0.0472913
DPYD dihydropyrimidine dehydrogenase 0.0468237
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0466294
ANKRD28 ankyrin repeat domain 28 0.0460781
ATXN1 ataxin 1 0.0455606
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0454449
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0440254
AKAP13 A kinase (PRKA) anchor protein 13 0.0435635
DST dystonin 0.0410505
PSD3 pleckstrin and Sec7 domain containing 3 0.0410381
TRIO trio Rho guanine nucleotide exchange factor 0.0392558
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0383368
LRMDA leucine rich melanocyte differentiation associated 0.037791
MEF2A myocyte enhancer factor 2A 0.0376859
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0366943
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.036564
IL1B interleukin 1, beta 0.0363161
MAML3 mastermind-like 3 (Drosophila) 0.035675
NRP1 neuropilin 1 0.0355166
GPC6 glypican 6 0.0352379
IFI44L interferon-induced protein 44-like 0.0347111
LOXL2 lysyl oxidase-like 2 0.0338223
TTC28 tetratricopeptide repeat domain 28 0.0338046
ARHGAP5 Rho GTPase activating protein 5 0.0337628
STC1 stanniocalcin 1 0.0335176
SEPTIN9 septin 9 0.0334999
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0320726
LPP LIM domain containing preferred translocation partner in lipoma 0.031367
ASPH aspartate beta-hydroxylase 0.0312307
TFPI2 tissue factor pathway inhibitor 2 0.0309898
LOX lysyl oxidase 0.030768
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0305161
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0304128
AADAC arylacetamide deacetylase 0.0303827
FER fer (fps/fes related) tyrosine kinase 0.0298897
VEGFA vascular endothelial growth factor A 0.0296919
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0296615
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0296167
NHSL1 NHS-like 1 0.0287088
EXOC4 exocyst complex component 4 0.0277352
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.027453
EHBP1 EH domain binding protein 1 0.026788
PTK2 protein tyrosine kinase 2 0.0265968
FAM107B family with sequence similarity 107, member B 0.0265531
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0265149
ETV6 ets variant 6 0.0262285
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0257473
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0256581
PRKCA protein kinase C, alpha 0.0256507
CDK14 cyclin-dependent kinase 14 0.0254962
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0253237
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0250938
FBXL13 F-box and leucine-rich repeat protein 13 0.0247685
ZNF638 zinc finger protein 638 0.0247382
MAML2 mastermind-like 2 (Drosophila) 0.0246902
IGF1R insulin-like growth factor 1 receptor 0.0245505
FNIP1 folliculin interacting protein 1 0.0245475
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0243943
HIPK2 homeodomain interacting protein kinase 2 0.0242568
ANO6 anoctamin 6 0.0237466
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.023246
HDAC9 histone deacetylase 9 0.0227478
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.022499
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0223084
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0222431
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0221967

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.160052
TMSB10 thymosin beta 10 -0.135859
VIM vimentin -0.115071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111684
FTL ferritin, light polypeptide -0.100966
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0882788
PTMA prothymosin, alpha -0.0809826
RPLP1 ribosomal protein, large, P1 -0.0578054
RPL35A ribosomal protein L35a -0.0566295
RPS19 ribosomal protein S19 -0.0423612
IER3 immediate early response 3 -0.0415507
GOLGA4 golgin A4 -0.0373592
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0369687
RPS6 ribosomal protein S6 -0.0341863
EIF1 eukaryotic translation initiation factor 1 -0.0338274
RPL23 ribosomal protein L23 -0.0335043
RPS29 ribosomal protein S29 -0.0329991
RPLP2 ribosomal protein, large, P2 -0.0317081
RPL34 ribosomal protein L34 -0.0311636
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0311573
KDM3A lysine (K)-specific demethylase 3A -0.0306668
RPS8 ribosomal protein S8 -0.0303902
WDR45B WD repeat domain 45B -0.0303777
RPS24 ribosomal protein S24 -0.0297754
RPL37A ribosomal protein L37a -0.0283746
GNAS GNAS complex locus -0.028245
ANXA2 annexin A2 -0.0280869
CALR calreticulin -0.0263474
RPS21 ribosomal protein S21 -0.0258982
YBX1 Y box binding protein 1 -0.0258473
USP3 ubiquitin specific peptidase 3 -0.025781
NAMPT nicotinamide phosphoribosyltransferase -0.0257266
RPL36 ribosomal protein L36 -0.0254464
ACTG1 actin gamma 1 -0.0251131
LMAN1 lectin, mannose-binding, 1 -0.0247999
RPL31 ribosomal protein L31 -0.024764
S100A6 S100 calcium binding protein A6 -0.0243522
VDAC1 voltage-dependent anion channel 1 -0.0243243
RPS13 ribosomal protein S13 -0.0237496
GARS1 glycyl-tRNA synthetase 1 -0.023616
SLC38A1 solute carrier family 38, member 1 -0.0235116
KPNB1 karyopherin (importin) beta 1 -0.0234829
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0229649
RBM39 RNA binding motif protein 39 -0.0226893
RPL32 ribosomal protein L32 -0.0223573
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0221716
TPT1 tumor protein, translationally-controlled 1 -0.0218457
RPL19 ribosomal protein L19 -0.0214438
RPS25 ribosomal protein S25 -0.0212895
PDIA3 protein disulfide isomerase family A, member 3 -0.0212743
FN1 fibronectin 1 -0.021154
RPS23 ribosomal protein S23 -0.0209423
RPL11 ribosomal protein L11 -0.0206857
RPL12 ribosomal protein L12 -0.0202967
HILPDA hypoxia inducible lipid droplet-associated -0.0199778
B2M beta-2-microglobulin -0.0194172
RPLP0 ribosomal protein, large, P0 -0.0193392
OGA O-GlcNAcase -0.0193207
S100A9 S100 calcium binding protein A9 -0.0192501
RAB1A RAB1A, member RAS oncogene family -0.0191556
RPS16 ribosomal protein S16 -0.0191209
RPS14 ribosomal protein S14 -0.0190082
RPL28 ribosomal protein L28 -0.0189492
PFN1 profilin 1 -0.0188369
EGR1 early growth response 1 -0.0187138
ARF4 ADP-ribosylation factor 4 -0.0186554
RPL37 ribosomal protein L37 -0.018488
RPS11 ribosomal protein S11 -0.0184
UGCG UDP-glucose ceramide glucosyltransferase -0.0183069
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0181623
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0180847
MARS1 methionyl-tRNA synthetase 1 -0.0180804
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0179807
MORF4L2 mortality factor 4 like 2 -0.0179363
RPS27 ribosomal protein S27 -0.017807
RPL7A ribosomal protein L7a -0.0177059
GSTP1 glutathione S-transferase pi 1 -0.0176502
RPS12 ribosomal protein S12 -0.017628
POTEF POTE ankyrin domain family, member F -0.017586
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.017538
RPS5 ribosomal protein S5 -0.0174197
STRN3 striatin, calmodulin binding protein 3 -0.0173369
TPM4 tropomyosin 4 -0.0172825
EIF5B eukaryotic translation initiation factor 5B -0.0170674
IFITM3 interferon induced transmembrane protein 3 -0.0168878
MARCHF6 membrane associated ring-CH-type finger 6 -0.0166133
SEC61G Sec61 gamma subunit -0.0161415
PRRC2C proline-rich coiled-coil 2C -0.0160168
RPL9 ribosomal protein L9 -0.0160032
RPL27A ribosomal protein L27a -0.0159928
PNISR PNN-interacting serine/arginine-rich protein -0.0159878
LOC112694756 uncharaterized LOC112694756 -0.0159746
SRP54 signal recognition particle 54kDa -0.0158801
RNF145 ring finger protein 145 -0.015817
MT2A metallothionein 2A -0.0156724
UBE2B ubiquitin-conjugating enzyme E2B -0.0156036
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0155938
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0154963
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0153521
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0152993