AZD-8055_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0926602
FMNL2 formin-like 2 0.0922193
DOCK4 dedicator of cytokinesis 4 0.071786
MACF1 microtubule-actin crosslinking factor 1 0.0613078
RICTOR RPTOR independent companion of MTOR, complex 2 0.0605907
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0595133
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0566828
TRIO trio Rho guanine nucleotide exchange factor 0.056073
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0545168
HSPA8 heat shock 70kDa protein 8 0.0544419
APP amyloid beta (A4) precursor protein 0.0541418
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0528608
THSD4 thrombospondin, type I, domain containing 4 0.0509156
TM4SF1 transmembrane 4 L six family member 1 0.0507147
FAM107B family with sequence similarity 107, member B 0.0496481
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0467712
ZFAND3 zinc finger, AN1-type domain 3 0.0465396
RBM39 RNA binding motif protein 39 0.0461948
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0445445
AKAP13 A kinase (PRKA) anchor protein 13 0.0426045
WAC WW domain containing adaptor with coiled-coil 0.041015
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0407687
PUM2 pumilio RNA-binding family member 2 0.0383102
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.038305
NCKAP1 NCK-associated protein 1 0.0378681
SOD2 superoxide dismutase 2, mitochondrial 0.0372103
ZEB1 zinc finger E-box binding homeobox 1 0.0369558
SAMD4A sterile alpha motif domain containing 4A 0.0363803
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0358001
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0337721
ERBIN erbb2 interacting protein 0.0336237
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0330391
RB1CC1 RB1-inducible coiled-coil 1 0.0326752
PARD3 par-3 family cell polarity regulator 0.0324357
RASAL2 RAS protein activator like 2 0.03221
MAPK8 mitogen-activated protein kinase 8 0.0307069
TPD52 tumor protein D52 0.0306096
DOCK5 dedicator of cytokinesis 5 0.0295171
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0295025
KDM3A lysine (K)-specific demethylase 3A 0.0294654
FNDC3B fibronectin type III domain containing 3B 0.0290452
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0289819
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.028521
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0283637
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0280028
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0279049
FLNB filamin B, beta 0.0279047
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0278064
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0277695
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0276467
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0270305
SPAG9 sperm associated antigen 9 0.0262275
PTK2 protein tyrosine kinase 2 0.0262245
ELL2 elongation factor, RNA polymerase II, 2 0.0258845
NIPBL Nipped-B homolog (Drosophila) 0.0258126
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0255485
SNX9 sorting nexin 9 0.0252999
NEK7 NIMA-related kinase 7 0.0249596
ITCH itchy E3 ubiquitin protein ligase 0.0248833
MATR3 matrin 3 0.0248656
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0232998
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0230363
GOLGA4 golgin A4 0.0228036
ERRFI1 ERBB receptor feedback inhibitor 1 0.0227419
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0227348
TFPI2 tissue factor pathway inhibitor 2 0.0226726
ITSN2 intersectin 2 0.0224424
SFPQ splicing factor proline/glutamine-rich 0.0223781
ABI1 abl-interactor 1 0.0222183
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.022195
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0221825
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0220182
UBASH3B ubiquitin associated and SH3 domain containing B 0.0218679
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218158
MT1X metallothionein 1X 0.021757
AHNAK AHNAK nucleoprotein 0.0217384
NRG1 neuregulin 1 0.0215312
FNBP1L formin binding protein 1-like 0.0211524
NAP1L1 nucleosome assembly protein 1-like 1 0.0209977
AGO2 argonaute RISC catalytic component 2 0.0209026
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0206817
MARCHF6 membrane associated ring-CH-type finger 6 0.0203981
BIRC6 baculoviral IAP repeat containing 6 0.0201108
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0198343
HBP1 HMG-box transcription factor 1 0.0197467
FNIP1 folliculin interacting protein 1 0.0196793
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0196489
SPIRE1 spire-type actin nucleation factor 1 0.0193613
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0189286
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0188804
LPP LIM domain containing preferred translocation partner in lipoma 0.018706
PUM1 pumilio RNA-binding family member 1 0.0187059
EIF1 eukaryotic translation initiation factor 1 0.0185539
MCL1 myeloid cell leukemia 1 0.0184777
ZNF292 zinc finger protein 292 0.0183871
KIF13A kinesin family member 13A 0.0183519
PRRC2C proline-rich coiled-coil 2C 0.0182059
JMJD1C jumonji domain containing 1C 0.0181342
KIF5B kinesin family member 5B 0.0181258
PCBP2 poly(rC) binding protein 2 0.0181044

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185894
PM20D1 peptidase M20 domain containing 1 -0.165552
TMSB10 thymosin beta 10 -0.0949463
FTL ferritin, light polypeptide -0.0908088
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0630093
FGB fibrinogen beta chain -0.055145
VIM vimentin -0.050105
PTMA prothymosin, alpha -0.0465252
LDHA lactate dehydrogenase A -0.0411088
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0407851
IGFBP3 insulin-like growth factor binding protein 3 -0.0385638
EGR1 early growth response 1 -0.0380592
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0362256
TPM4 tropomyosin 4 -0.0354708
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0353927
BASP1 brain abundant, membrane attached signal protein 1 -0.0350024
RPL23 ribosomal protein L23 -0.0344133
RPL35A ribosomal protein L35a -0.0336353
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0311315
NEGR1 neuronal growth regulator 1 -0.0309492
EFNA5 ephrin-A5 -0.0304748
NNMT nicotinamide N-methyltransferase -0.0304219
PKM pyruvate kinase, muscle -0.0303829
RPLP1 ribosomal protein, large, P1 -0.0301345
IGFBP4 insulin-like growth factor binding protein 4 -0.0300501
RPS19 ribosomal protein S19 -0.0295695
FTH1 ferritin, heavy polypeptide 1 -0.0293121
FGA fibrinogen alpha chain -0.0290016
RPS29 ribosomal protein S29 -0.0279394
PFN1 profilin 1 -0.0277826
RPS8 ribosomal protein S8 -0.0268713
PDIA3 protein disulfide isomerase family A, member 3 -0.0268292
TPM1 tropomyosin 1 (alpha) -0.0264701
POTEF POTE ankyrin domain family, member F -0.0263654
CALR calreticulin -0.0257627
IGF2 insulin-like growth factor 2 -0.0254047
ENO1 enolase 1, (alpha) -0.0242739
ACTG1 actin gamma 1 -0.0237537
RPL19 ribosomal protein L19 -0.0224482
FGG fibrinogen gamma chain -0.0219623
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0216565
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0210494
RPS6 ribosomal protein S6 -0.0209033
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0206407
SRGN serglycin -0.0204615
S100A10 S100 calcium binding protein A10 -0.0203621
VCL vinculin -0.020262
B2M beta-2-microglobulin -0.0198503
HLA-B major histocompatibility complex, class I, B -0.019623
RPL31 ribosomal protein L31 -0.0193906
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0192293
RAD51B RAD51 paralog B -0.0192281
NEBL nebulette -0.0192241
S100A6 S100 calcium binding protein A6 -0.0190088
NCOA7 nuclear receptor coactivator 7 -0.0189378
KYNU kynureninase -0.0187679
CNRIP1 cannabinoid receptor interacting protein 1 -0.0187097
S100A11 S100 calcium binding protein A11 -0.018452
SERF2 small EDRK-rich factor 2 -0.0183296
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0182727
RPS21 ribosomal protein S21 -0.0172941
UQCRB ubiquinol-cytochrome c reductase binding protein -0.017285
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0171254
PDIA6 protein disulfide isomerase family A, member 6 -0.0170908
ATP5F1E ATP synthase F1 subunit epsilon -0.016872
ZBTB20 zinc finger and BTB domain containing 20 -0.0167841
ATP5F1B ATP synthase F1 subunit beta -0.0167369
PRDX1 peroxiredoxin 1 -0.016699
LOC102724023 ES1 protein homolog, mitochondrial -0.0165331
TPI1 triosephosphate isomerase 1 -0.0164381
RPL36 ribosomal protein L36 -0.0163656
CAVIN1 caveolae associated protein 1 -0.0162113
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0160435
ANXA2 annexin A2 -0.0158885
RPL37A ribosomal protein L37a -0.0158362
PLS3 plastin 3 -0.0157942
RPS27 ribosomal protein S27 -0.0156403
RPS27A ribosomal protein S27a -0.0155595
IFITM3 interferon induced transmembrane protein 3 -0.0154521
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0151991
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0150931
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0150424
RPS15 ribosomal protein S15 -0.015034
RNF213 ring finger protein 213 -0.0149122
HLA-A major histocompatibility complex, class I, A -0.0148848
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0146519
TNS3 tensin 3 -0.0146127
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0144054
VMP1 vacuole membrane protein 1 -0.0142084
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0141823
LDHB lactate dehydrogenase B -0.0140863
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0139742
RPLP2 ribosomal protein, large, P2 -0.0139243
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0138572
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0138399
RPL8 ribosomal protein L8 -0.0137905
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0137904
SMOC1 SPARC related modular calcium binding 1 -0.0136765
HMGA1 high mobility group AT-hook 1 -0.0133177
EHBP1 EH domain binding protein 1 -0.0131934