AZD-8055_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD-8055 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD-8055_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.173348
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.114561
FTL ferritin, light polypeptide 0.105572
VIM vimentin 0.101997
TPT1 tumor protein, translationally-controlled 1 0.101739
B2M beta-2-microglobulin 0.0955468
CXCL8 chemokine (C-X-C motif) ligand 8 0.0835202
TXNRD1 thioredoxin reductase 1 0.0752326
MCTP1 multiple C2 domains, transmembrane 1 0.0740894
HMGA2 high mobility group AT-hook 2 0.0714308
PTMA prothymosin, alpha 0.0708836
FN1 fibronectin 1 0.067102
GOLGA4 golgin A4 0.0664083
MYOF myoferlin 0.0617141
NDRG1 N-myc downstream regulated 1 0.0563379
GPC6 glypican 6 0.055484
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0549497
MT2A metallothionein 2A 0.0522877
RPL7 ribosomal protein L7 0.0509189
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0505842
MYO1E myosin IE 0.0496143
OXR1 oxidation resistance 1 0.0463596
NAMPT nicotinamide phosphoribosyltransferase 0.0460179
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0454403
LIMS1 LIM and senescent cell antigen-like domains 1 0.0443863
RPS12 ribosomal protein S12 0.044311
RCOR1 REST corepressor 1 0.0441002
RPS15 ribosomal protein S15 0.0440072
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0439363
RACK1 receptor for activated C kinase 1 0.0433677
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0433514
PRKCA protein kinase C, alpha 0.0430331
ENO1 enolase 1, (alpha) 0.0426334
SEPTIN7 septin 7 0.0425103
RBM47 RNA binding motif protein 47 0.042148
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0420154
FUS FUS RNA binding protein 0.0403504
RPLP1 ribosomal protein, large, P1 0.0399052
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.039076
FMNL2 formin-like 2 0.0390364
NAV1 neuron navigator 1 0.0390264
EGFR epidermal growth factor receptor 0.0385127
GCC2 GRIP and coiled-coil domain containing 2 0.0382908
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0378024
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0377715
PCDH7 protocadherin 7 0.0376122
EPS8 epidermal growth factor receptor pathway substrate 8 0.0375532
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0372352
SLC38A2 solute carrier family 38, member 2 0.036988
ATG12 autophagy related 12 0.0368802
PTBP3 polypyrimidine tract binding protein 3 0.0368633
MMP1 matrix metallopeptidase 1 0.0368023
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0367841
SQSTM1 sequestosome 1 0.0365813
SMYD3 SET and MYND domain containing 3 0.0360614
TRIO trio Rho guanine nucleotide exchange factor 0.0358336
NAP1L1 nucleosome assembly protein 1-like 1 0.0353372
RPL37A ribosomal protein L37a 0.0353353
GPHN gephyrin 0.0350081
RPS3 ribosomal protein S3 0.0348265
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0344757
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0333328
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0333327
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0330371
HLA-A major histocompatibility complex, class I, A 0.0330103
RPL26 ribosomal protein L26 0.0317598
RPLP2 ribosomal protein, large, P2 0.0316941
HELZ helicase with zinc finger 0.0314373
HLA-B major histocompatibility complex, class I, B 0.0314333
RPS2 ribosomal protein S2 0.0313863
YBX3 Y box binding protein 3 0.0313398
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0310822
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0310193
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0309328
RPL12 ribosomal protein L12 0.0307259
TMF1 TATA element modulatory factor 1 0.0305442
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0304396
ZFP36L1 ZFP36 ring finger protein-like 1 0.0303068
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301997
MYO10 myosin X 0.0301544
FBXL13 F-box and leucine-rich repeat protein 13 0.0300359
TPI1 triosephosphate isomerase 1 0.02998
PDIA4 protein disulfide isomerase family A, member 4 0.029961
RPS6 ribosomal protein S6 0.0298417
ZNF654 zinc finger protein 654 0.0295941
RLF rearranged L-myc fusion 0.0295183
SCAF11 SR-related CTD-associated factor 11 0.029436
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0291349
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0289924
PTGES2 prostaglandin E synthase 2 0.0289657
RSRC2 arginine/serine-rich coiled-coil 2 0.028835
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0284063
AGO3 argonaute RISC catalytic component 3 0.0282122
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0281498
S100P S100 calcium binding protein P 0.0278259
IFI16 interferon, gamma-inducible protein 16 0.0276879
KDM5B lysine (K)-specific demethylase 5B 0.0275523
FNDC3B fibronectin type III domain containing 3B 0.0274803
RNF24 ring finger protein 24 0.0273456
IRS2 insulin receptor substrate 2 0.0270805

decreased expression

Symbol Name Standardized Value
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.185316
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.138109
KRT17 keratin 17, type I -0.13397
LAMB3 laminin, beta 3 -0.126911
ANXA2 annexin A2 -0.126221
ATOSA atos homolog A -0.10329
LMO7 LIM domain 7 -0.0864403
CEMIP cell migration inducing protein, hyaluronan binding -0.0858699
MUC16 mucin 16, cell surface associated -0.0820575
BACE2 beta-site APP-cleaving enzyme 2 -0.0808025
F3 coagulation factor III (thromboplastin, tissue factor) -0.0689335
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0688698
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0687465
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0672092
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0659084
TM4SF1 transmembrane 4 L six family member 1 -0.0648638
SLMAP sarcolemma associated protein -0.0647438
EZR ezrin -0.0611283
ERRFI1 ERBB receptor feedback inhibitor 1 -0.059501
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0594574
IGF2 insulin-like growth factor 2 -0.0582114
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0556115
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0553095
IGF1R insulin-like growth factor 1 receptor -0.0552772
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.053493
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0523391
TJP1 tight junction protein 1 -0.0501782
SVIL supervillin -0.0487783
MYO9A myosin IXA -0.0481938
CDH13 cadherin 13 -0.0478314
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.047708
CMIP c-Maf inducing protein -0.0476396
BTG1 B-cell translocation gene 1, anti-proliferative -0.0469749
IFIH1 interferon induced with helicase C domain 1 -0.0468089
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0460199
BMAL2 basic helix-loop-helix ARNT like 2 -0.0453331
PDE4D phosphodiesterase 4D, cAMP-specific -0.0450696
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0448395
MACC1 metastasis associated in colon cancer 1 -0.0441879
BZW1 basic leucine zipper and W2 domains 1 -0.0441591
ABHD17C abhydrolase domain containing 17C -0.0440407
RUNX1 runt-related transcription factor 1 -0.043538
RND3 Rho family GTPase 3 -0.0425495
ZSWIM6 zinc finger, SWIM-type containing 6 -0.042117
S100A11 S100 calcium binding protein A11 -0.0419817
KYNU kynureninase -0.0418113
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0417182
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0416333
MCL1 myeloid cell leukemia 1 -0.0415019
TMEM165 transmembrane protein 165 -0.0414744
PDLIM5 PDZ and LIM domain 5 -0.0408531
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0405157
CDK13 cyclin-dependent kinase 13 -0.040165
JUP junction plakoglobin -0.0400389
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0399201
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0391569
WDFY3 WD repeat and FYVE domain containing 3 -0.0389478
HMBOX1 homeobox containing 1 -0.0382544
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0382406
ANXA3 annexin A3 -0.037573
QKI QKI, KH domain containing, RNA binding -0.0375286
PSD3 pleckstrin and Sec7 domain containing 3 -0.0374571
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0369391
KIF13B kinesin family member 13B -0.0366985
DENND2C DENN/MADD domain containing 2C -0.0362664
ITGB4 integrin, beta 4 -0.0362094
COPA coatomer protein complex, subunit alpha -0.0361396
MYO6 myosin VI -0.0359791
SNX9 sorting nexin 9 -0.0359671
PARD6B par-6 family cell polarity regulator beta -0.035691
DENND4A DENN/MADD domain containing 4A -0.035372
MRPS6 mitochondrial ribosomal protein S6 -0.0351512
NCOR2 nuclear receptor corepressor 2 -0.0350852
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.034811
PATJ PATJ crumbs cell polarity complex component -0.0346299
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0344114
SAMD4A sterile alpha motif domain containing 4A -0.0342339
FNDC3A fibronectin type III domain containing 3A -0.034209
KDM7A lysine (K)-specific demethylase 7A -0.0339063
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0337487
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0321597
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0320829
SOX4 SRY (sex determining region Y)-box 4 -0.0320398
SON SON DNA binding protein -0.0320317
TRA2A transformer 2 alpha homolog (Drosophila) -0.0320302
USP53 ubiquitin specific peptidase 53 -0.0318937
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0317275
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.031389
DSG2 desmoglein 2 -0.0312025
AGO2 argonaute RISC catalytic component 2 -0.0308658
ZNF609 zinc finger protein 609 -0.0308563
TAOK1 TAO kinase 1 -0.0305667
DUSP4 dual specificity phosphatase 4 -0.0303241
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0300499
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0299885
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0294475
FBXL17 F-box and leucine-rich repeat protein 17 -0.0294291
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0294095
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0293206
LAMC2 laminin, gamma 2 -0.0292239