| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD-8055_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.541871 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.134509 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.102868 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0770905 |
| YBX3 | Y box binding protein 3 | 0.0770438 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0736336 |
| MCL1 | myeloid cell leukemia 1 | 0.0724024 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0687194 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0655161 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.063493 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0597394 |
| RPS3 | ribosomal protein S3 | 0.0584511 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0580803 |
| HMGA2 | high mobility group AT-hook 2 | 0.0579105 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0565566 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0563215 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0562359 |
| GOLGB1 | golgin B1 | 0.0551091 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0536129 |
| ATXN1 | ataxin 1 | 0.0535719 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0512313 |
| FMNL2 | formin-like 2 | 0.0510475 |
| AEBP2 | AE binding protein 2 | 0.0500995 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0498402 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0492574 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0490426 |
| PDE10A | phosphodiesterase 10A | 0.0483717 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0474773 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0473385 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0458578 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0451146 |
| SVIL | supervillin | 0.0425217 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0423422 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0423293 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0421899 |
| HLA-B | major histocompatibility complex, class I, B | 0.04211 |
| RPS2 | ribosomal protein S2 | 0.0419636 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0417271 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0409166 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0398336 |
| DSPP | dentin sialophosphoprotein | 0.0394803 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.03919 |
| EGFR | epidermal growth factor receptor | 0.0391369 |
| EXOC4 | exocyst complex component 4 | 0.0378793 |
| PYGL | phosphorylase, glycogen, liver | 0.0377277 |
| DST | dystonin | 0.0368153 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0367777 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0367168 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0361851 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0360534 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0360007 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0351109 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0340795 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0339433 |
| RPS8 | ribosomal protein S8 | 0.0332901 |
| OSMR | oncostatin M receptor | 0.0329015 |
| RPL37A | ribosomal protein L37a | 0.0328547 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0319194 |
| RPL37 | ribosomal protein L37 | 0.0315031 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0314873 |
| HOMER1 | homer scaffolding protein 1 | 0.0313389 |
| CUX1 | cut-like homeobox 1 | 0.030617 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0304974 |
| PRELID2 | PRELI domain containing 2 | 0.0301949 |
| WWOX | WW domain containing oxidoreductase | 0.0295732 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0293871 |
| RPL26 | ribosomal protein L26 | 0.0290672 |
| SIK3 | SIK family kinase 3 | 0.028985 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0287473 |
| STC1 | stanniocalcin 1 | 0.0282393 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0281813 |
| EXT1 | exostosin glycosyltransferase 1 | 0.027868 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0278483 |
| INTS6 | integrator complex subunit 6 | 0.0273164 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0271897 |
| RYR3 | ryanodine receptor 3 | 0.0269061 |
| RPS12 | ribosomal protein S12 | 0.0268559 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0263598 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0261393 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0261199 |
| RPS18 | ribosomal protein S18 | 0.0260858 |
| ACTG1 | actin gamma 1 | 0.0260328 |
| USP34 | ubiquitin specific peptidase 34 | 0.0258362 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0257745 |
| RPL31 | ribosomal protein L31 | 0.0256236 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0255303 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0255001 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0250566 |
| CTTN | cortactin | 0.0247866 |
| NEK10 | NIMA-related kinase 10 | 0.0247555 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0247487 |
| RPS10 | ribosomal protein S10 | 0.0246651 |
| LOXL2 | lysyl oxidase-like 2 | 0.0245628 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0243968 |
| RPL11 | ribosomal protein L11 | 0.0242619 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0241721 |
| PRKCE | protein kinase C, epsilon | 0.0241498 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0239743 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0237035 |
| ATP11A | ATPase, class VI, type 11A | 0.0234714 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.119109 |
| TXNRD1 | thioredoxin reductase 1 | -0.103205 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0777162 |
| RTN4 | reticulon 4 | -0.0607459 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0504981 |
| PHIP | pleckstrin homology domain interacting protein | -0.0488189 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0482593 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0474676 |
| EGR1 | early growth response 1 | -0.0424772 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0420264 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0394324 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0377777 |
| CCNL1 | cyclin L1 | -0.0319174 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0313508 |
| DIAPH3 | diaphanous-related formin 3 | -0.0308884 |
| RRM2 | ribonucleotide reductase M2 | -0.0303811 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0285679 |
| PFN1 | profilin 1 | -0.0283147 |
| MKI67 | marker of proliferation Ki-67 | -0.0282782 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0282351 |
| PTMA | prothymosin, alpha | -0.0282188 |
| TMSB10 | thymosin beta 10 | -0.0281325 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0276912 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0274859 |
| XPO1 | exportin 1 | -0.0269967 |
| RBM25 | RNA binding motif protein 25 | -0.0264818 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0262016 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0260124 |
| TMEM165 | transmembrane protein 165 | -0.0258871 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0257386 |
| LDHB | lactate dehydrogenase B | -0.0241112 |
| MELK | maternal embryonic leucine zipper kinase | -0.0239703 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0236941 |
| DEK | DEK proto-oncogene | -0.0235816 |
| OGA | O-GlcNAcase | -0.0235421 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0229078 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.022801 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0226111 |
| TMPO | thymopoietin | -0.0224884 |
| ANLN | anillin, actin binding protein | -0.0222508 |
| NUP153 | nucleoporin 153kDa | -0.0220348 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0215825 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0214938 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0214901 |
| PGK1 | phosphoglycerate kinase 1 | -0.0214166 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0213348 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0212024 |
| ZFR | zinc finger RNA binding protein | -0.0210592 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0210559 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0209797 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.020884 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0208422 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0207802 |
| CEP95 | centrosomal protein 95kDa | -0.0206309 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0204064 |
| BBX | bobby sox homolog (Drosophila) | -0.020256 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0201431 |
| STIL | SCL/TAL1 interrupting locus | -0.0199818 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.019734 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0197277 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0193096 |
| WDR45B | WD repeat domain 45B | -0.0191425 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0190666 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0190608 |
| SGO2 | shugoshin 2 | -0.0189625 |
| HMGA1 | high mobility group AT-hook 1 | -0.0188946 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0188767 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0187244 |
| CIP2A | cellular inhibitor of PP2A | -0.0186589 |
| TUBA1B | tubulin, alpha 1b | -0.0185459 |
| ANXA5 | annexin A5 | -0.0185209 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0185142 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0183128 |
| RNF38 | ring finger protein 38 | -0.0182067 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0180477 |
| NUP155 | nucleoporin 155kDa | -0.0179041 |
| RBL1 | retinoblastoma-like 1 | -0.0178479 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.017846 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0178319 |
| BSG | basigin (Ok blood group) | -0.0176836 |
| TMEM41B | transmembrane protein 41B | -0.0175217 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0173038 |
| KIF2C | kinesin family member 2C | -0.0172667 |
| TBK1 | TANK-binding kinase 1 | -0.0171922 |
| NOP58 | NOP58 ribonucleoprotein | -0.0171235 |
| KIF18B | kinesin family member 18B | -0.0170519 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0169792 |
| TNPO3 | transportin 3 | -0.0169281 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0169064 |
| CBX3 | chromobox homolog 3 | -0.0167759 |
| SEPTIN7 | septin 7 | -0.0165547 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0164458 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0163765 |
| ZNF292 | zinc finger protein 292 | -0.0163722 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0163318 |
| CDC27 | cell division cycle 27 | -0.0162915 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0162697 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0162545 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0162074 |
| KCMF1 | potassium channel modulatory factor 1 | -0.016129 |
