| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD-8055 perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the AZD-8055_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.223426 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.117466 |
| CDH13 | cadherin 13 | 0.113831 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.108499 |
| EFNA5 | ephrin-A5 | 0.0745397 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0742282 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0738707 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0719972 |
| PCBP3 | poly(rC) binding protein 3 | 0.0589122 |
| FN1 | fibronectin 1 | 0.0542178 |
| PDE10A | phosphodiesterase 10A | 0.0541119 |
| ASPH | aspartate beta-hydroxylase | 0.054098 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0538796 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.051841 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0510195 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0470748 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0460026 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0446432 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0424633 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0418963 |
| MCL1 | myeloid cell leukemia 1 | 0.0408833 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.039906 |
| STC1 | stanniocalcin 1 | 0.0381873 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0362327 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0359143 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0353311 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.034837 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0344222 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0343408 |
| GRAMD1B | GRAM domain containing 1B | 0.0339742 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0332778 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0322244 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0308232 |
| PRELID2 | PRELI domain containing 2 | 0.030707 |
| CD44 | CD44 molecule (Indian blood group) | 0.0283386 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0279653 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0276784 |
| SMAD2 | SMAD family member 2 | 0.0271965 |
| INHBA | inhibin, beta A | 0.0261934 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0260709 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0260098 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0258066 |
| HSPA8 | heat shock 70kDa protein 8 | 0.025522 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0252926 |
| FNIP1 | folliculin interacting protein 1 | 0.0252708 |
| RAD51B | RAD51 paralog B | 0.0252326 |
| KYNU | kynureninase | 0.024975 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0248693 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0248003 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0242781 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0241907 |
| CHL1 | cell adhesion molecule L1-like | 0.0239067 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0237254 |
| DENND1A | DENN/MADD domain containing 1A | 0.0234139 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.023025 |
| ESM1 | endothelial cell-specific molecule 1 | 0.0230247 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0228152 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0220978 |
| BMP6 | bone morphogenetic protein 6 | 0.0220328 |
| HDAC4 | histone deacetylase 4 | 0.0219819 |
| PYGL | phosphorylase, glycogen, liver | 0.0217742 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0211623 |
| GLIS3 | GLIS family zinc finger 3 | 0.0211412 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0210044 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0209586 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0206522 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0201949 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.019961 |
| FMNL2 | formin-like 2 | 0.019937 |
| PRKCA | protein kinase C, alpha | 0.019778 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.0194557 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0194524 |
| FAM107B | family with sequence similarity 107, member B | 0.0192394 |
| PCDH9 | protocadherin 9 | 0.0185728 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0184622 |
| CTSL | cathepsin L | 0.0183522 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0181877 |
| TENM2 | teneurin transmembrane protein 2 | 0.0180286 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0177797 |
| NHSL1 | NHS-like 1 | 0.0176816 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0174032 |
| INTS6 | integrator complex subunit 6 | 0.0168662 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0167879 |
| AUTS2 | autism susceptibility candidate 2 | 0.0165481 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.016477 |
| NCKAP5 | NCK-associated protein 5 | 0.0164202 |
| NBEAL1 | neurobeachin-like 1 | 0.016199 |
| LSAMP | limbic system-associated membrane protein | 0.0157868 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0157639 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0156741 |
| AADAC | arylacetamide deacetylase | 0.0156224 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0155944 |
| UNC5D | unc-5 homolog D (C. elegans) | 0.0155345 |
| HMGA2 | high mobility group AT-hook 2 | 0.0154539 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.015335 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0147374 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0143532 |
| RPS18 | ribosomal protein S18 | 0.0143517 |
| SVIL | supervillin | 0.0142077 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0141655 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107413 |
| FTL | ferritin, light polypeptide | -0.0932851 |
| PTMA | prothymosin, alpha | -0.0637365 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0624821 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0611911 |
| RTN4 | reticulon 4 | -0.0607757 |
| TXNRD1 | thioredoxin reductase 1 | -0.0595792 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0589761 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0581651 |
| NEK7 | NIMA-related kinase 7 | -0.0458812 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0431966 |
| TMSB10 | thymosin beta 10 | -0.0429413 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0429184 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0389194 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0375373 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0360593 |
| OGA | O-GlcNAcase | -0.0353328 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0337042 |
| RBM39 | RNA binding motif protein 39 | -0.0334049 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0324154 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0322877 |
| GNAS | GNAS complex locus | -0.028901 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0286473 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.027555 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0275546 |
| MFF | mitochondrial fission factor | -0.025897 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0253895 |
| ACTG1 | actin gamma 1 | -0.0249529 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.024952 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0248227 |
| RPS6 | ribosomal protein S6 | -0.0244567 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0243804 |
| PHF20 | PHD finger protein 20 | -0.0243057 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0242995 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0241271 |
| RPL37A | ribosomal protein L37a | -0.023961 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0238873 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0229896 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0228867 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.022725 |
| PTEN | phosphatase and tensin homolog | -0.0226842 |
| VIM | vimentin | -0.022543 |
| CENPF | centromere protein F, 350/400kDa | -0.022008 |
| OLFML2A | olfactomedin-like 2A | -0.0219429 |
| SEPTIN7 | septin 7 | -0.021783 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0217387 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0217379 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0213334 |
| RPL35A | ribosomal protein L35a | -0.0212656 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0212339 |
| GDA | guanine deaminase | -0.0210299 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0207525 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0205666 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0204483 |
| USP3 | ubiquitin specific peptidase 3 | -0.0204324 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0203641 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0202841 |
| GOLGA4 | golgin A4 | -0.0200971 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0200965 |
| SPAG9 | sperm associated antigen 9 | -0.0198162 |
| TBXT | T-box transcription factor T | -0.0197411 |
| WDR45B | WD repeat domain 45B | -0.0195884 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0195541 |
| RPL23 | ribosomal protein L23 | -0.0195314 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0190687 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0189041 |
| TNPO1 | transportin 1 | -0.0188557 |
| NUP58 | nucleoporin 58 | -0.0188009 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0187891 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.0187565 |
| RBM25 | RNA binding motif protein 25 | -0.0186764 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0185606 |
| ENAH | enabled homolog (Drosophila) | -0.018313 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0182838 |
| COL5A2 | collagen, type V, alpha 2 | -0.0182556 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0180306 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0178506 |
| RPL13A | ribosomal protein L13a | -0.0178241 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0176841 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0175621 |
| RPS29 | ribosomal protein S29 | -0.0173356 |
| S100A6 | S100 calcium binding protein A6 | -0.0172469 |
| YBX1 | Y box binding protein 1 | -0.0172007 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0171947 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0169422 |
| SETD5 | SET domain containing 5 | -0.0169274 |
| RAI1 | retinoic acid induced 1 | -0.0169201 |
| RPS8 | ribosomal protein S8 | -0.01692 |
| SMYD3 | SET and MYND domain containing 3 | -0.0168046 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0167994 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0167906 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0167206 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0166501 |
| RPLP2 | ribosomal protein, large, P2 | -0.016544 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0165367 |
| POTEF | POTE ankyrin domain family, member F | -0.0164866 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0163997 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0162971 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0162784 |
| PCBP2 | poly(rC) binding protein 2 | -0.0162241 |
